The application of Sheng-Mai Injection in diabetes mellitus and related complications: a systematic review and meta-analysis

2021 ◽  
Vol 21 ◽  
Author(s):  
Maoyi Yang ◽  
Zhipeng Hu ◽  
Rensong Yue
Keyword(s):  
Diabetes Mellitus ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Tibial Nerve ◽  
Motor Nerve ◽  
Meta Analysis ◽  
Fasting Blood Glucose ◽  
Sensory Nerve ◽  
Motor Nerve Conduction Velocity

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by progressive β cell dysfunction. Sheng-Mai Injection (SMI), a Traditional Chinese medicine preparation, is widely used for DM and related complications. Objective: The study aims to summarize the applications of SMI in DM and related complications by meta-analysis. Methods: Eight databases were searched, and meta-analyses were performed. Results : Fifteen studies, including 1273 participants, were included. All studies and participants are from China. Pooled effects showed that SMI might reduce glycated hemoglobin (MD -0.46%; 95% CI -0.89 to -0.03; P < 0.01), fasting blood glucose (MD -0.83 mmol/L; 95% CI -1.30 to -0.36; P < 0.01), two-hour Postprandial glucose (MD -1.27 mmol/L; 95% CI -1.96 to -0.58; P < 0.01), 24-hour urinary protein (MD -0.28 mg; 95% CI -0.51 to -0.06; P = 0.01), blood urea nitrogen (MD -1.31 mg; 95% CI -2.08 to -0.54; P < 0.05), Scr (MD -2.60; 95% CI -3.43 to -1.77; P < 0.05), ulnar nerve motor nerve conduction velocity (MNCV) (MD 1.45; 95% CI 0.03 to 2.87; P < 0.05) and tibial nerve Sensory nerve conduction velocity (SNCV) (MD 1.84; 95% CI 0.1 to 3.58; P < 0.05). There was no evidence of effect on common peroneal nervous MNCV and SNCV, tibial nerve MNCV, median nerve MNCV and SNCV. Adverse effects included less frequent gastrointestinal reactions, elevated transaminase, leucopenia, fever, and rash. Conclusion: SMI may be effective in DM and diabetic nephropathy. For diabetic peripheral neuropathy, the effectiveness cannot yet be proven considering the inconsistency of the evidence.

scholarly journals Effect of Neurodynamic Mobilisation Plus Core Stability on Pain and Motor Nerve Conduction Velocity in Athletes with Lumbar Radiculopathy

2021 ◽  
Vol 28 (3) ◽  
pp. 3-7
Author(s):  
Rashmi Gupta ◽  
Shalini Sharma ◽  
Raj Kumar Sharma ◽  
Saurabh Sharma
Keyword(s):  
Outcome Measures ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Tibial Nerve ◽  
Motor Nerve ◽  
Motor Nerve Conduction Velocity ◽  
Core Stability ◽  
Lumbar Radiculopathy ◽  
Motor Nerve Conduction

Abstract Introduction. Lumbar radiculopathy (LR) is a common debilitating disorder of neuromuscular origin that affects athletes. Material and Methods. This study was a parallel group design and a total of 24 clinically diagnosed athletes with LR were recruited for the study and randomly assigned to one of the two groups, i.e. neurodynamic mobilisation plus core stability group (NDS plus CS) and core stability group only (CS). NDS plus CS underwent neural mobilisation of the tibial nerve and core stability exercises, while CS group performed core stability for a total of 14 sessions on alternate days. The outcome measures of motor nerve conduction velocity (m NCV) of the tibial nerve and pain intensity were recorded before the start of the intervention, at midpoint (7th session) and at the end of the intervention (14th session). Results. Baseline scores of pain and m NCV (NDS plus CS: 6.75 ± 0.62, 38.10 ± 7.21 and CS: 6.58 ± 0.79, 38.92 ± 6.37) were non-significant. The outcome measures improved significantly during treatment in NDS plus CS group (baseline to 7th session, 7th to 14th session and overall mean change for pain and m NCV was found to be 4.74 ± 0.37 and -6.43 ± 3.08, respectively. Non-significant improvement was reported for CS group. Two-way repeated measures (2 x 3) ANOVA was used to analyse the change in the outcome measures and revealed that NDS plus CS group showed statistically significant main effects for group on pain level (F (2, 5.34) = 0.89, p < 0.001 and m NCV (F (2, 5.21) = 0.40, p < 0.03. Significant time and group x time interaction effects were also found. Conclusions. The findings of the study revealed that neurodynamic mobilisation plus core stability were found effective in improving pain level and motor nerve conduction velocity of the tibial nerve in athletes with lumbar radiculopathy.

scholarly journals Efficacy and Safety of the Injection of the Traditional Chinese Medicine Puerarin for the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis of 53 Randomized Controlled Trials

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Baocheng Xie ◽  
Qinghui Wang ◽  
Chenhui Zhou ◽  
Jiahuan Wu ◽  
Daohua Xu
Keyword(s):  
Peripheral Neuropathy ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Meta Analysis ◽  
Sensory Nerve ◽  
Control Group ◽  
Efficacy And Safety

Objective. The injection of the traditional Chinese patent medicine puerarin has been widely used in the treatment of various diseases such as angina pectoris or ischemic stroke. We aim to evaluate the efficacy and safety of puerarin injection for the treatment of diabetic peripheral neuropathy (DPN). Methods. A systematic literature search was performed in seven medical databases from their inception until June 2017. 53 studies with RCTs, totaling 3284 patients, were included in this meta-analysis. The included studies were assessed by the Cochrane risk of bias and analyzed by Review Manager 5.3 software. Results. The meta-analysis showed that puerarin injection for the treatment of DPN was significantly better compared with the control group in terms of the total effective rate. The result showed that puerarin injection for the treatment of DPN can significantly increase the probability of sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of the median and peroneal nerves. Conclusions. This meta-analysis demonstrated that puerarin injection may be more effective and safe for the treatment of DPN. However, further and higher quality RCTs are required to prove its efficacy and provide meaningful evidence for clinical treatment due to the poor methodological quality.

Motor Nerve Conduction Velocity in Diabetes Mellitus

Diabetes ◽  
1961 ◽  
Vol 10 (1) ◽  
pp. 46-51 ◽  
Author(s):  
T. G. Skillman ◽  
E. W. Johnson ◽  
G. J. Hamwi ◽  
H. J. Driskill
Keyword(s):  
Diabetes Mellitus ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Motor Nerve Conduction Velocity ◽  
Motor Nerve Conduction

Control of Uremic Neuropathy by Equilibrium Peritoneal Dialysis

1984 ◽  
Vol 7 (2) ◽  
pp. 97-100 ◽  
Author(s):  
U. Buoncristiani ◽  
G. Mazzotta ◽  
C. Carobi ◽  
V. Gallai ◽  
M. Cozzari ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Motor Nerve Conduction Velocity ◽  
Lower Limbs ◽  
Motor Nerve Conduction ◽  
Extracorporeal Dialysis

Motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNVC) and distal motor latencies times (DMLT) were evaluated both in upper and lower limbs in three groups of 15 patients of comparable age, treated respectively by extracorporeal dialysis (HD), continuous ambulatory peritoneal dialysis (CAPD) and combined peritoneal dialysis (CPD) for comparable sufficiently long periods. Moreover, MNCV was monitored longitudinally in two groups of patients shifted from CAPD to HD and vice versa. The results show a significant superiority of peritoneal dialysis and particularly of CAPD with respect to HD in controlling uremic neuropathy.

Very Early Neurophysiological Study in Guillain-Barre Syndrome

2018 ◽  
Vol 80 (1-2) ◽  
pp. 100-105 ◽  
Author(s):  
Jiaoting Jin ◽  
Fangfang Hu ◽  
Xing Qin ◽  
Xuan Liu ◽  
Min Li ◽  
...  
Keyword(s):  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Tibial Nerve ◽  
Early Stage ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Sensory Nerves ◽  
Motor Nerve Conduction ◽  
Abnormal Rate ◽  
Motor Nerves

Purpose: The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. Methods: We prospectively recruited patients with a diagnosis of GBS discharged from First Affiliated Hospital of Xi’an Jiaotong University and Xi Jing Hospital. Patients were classified into 3 groups according to the onset of symptoms to electromyography examination interval (OEI). The neurophysiological findings were carried out using standard procedures. All patients were examined by the same experienced neurophysiologist. Results: There were not significant group differences in abnormal rate, distal motor latency (DML), motor nerve conduction velocity (MNCV), F response (FR), compound muscle action potential (CMAP), conduction block (CB), sensory nerve action potential (SNAP), and sensory nerve conduction velocity among OEI ≤4 days, 4< OEI ≤10 days, and OEI > 10 days groups. Motor nerves were more affected than sensory nerves in neurophysiological presentation in very early stage patients. The difference of motor nerves and sensory nerves was statistically significant in lower limbs, but was not in upper limbs. In motor nerve conduction studies, the abnormal rate of DML, MNCV, FR, CB was more common seen in ulnar and peroneal nerve than median and tibial nerve, the abnormal rate of CMAP was the same in ulnar, median, peroneal and tibial nerve. In sensory nerve conduction studies, the abnormal rate of ulnar nerve and median nerve was higher than the superficial peroneal nerve and sural nerve. The OEI was not correlated with the SNAP decrease rate of median (r = 0.10, p = 0.23) and ulnar (r = 0.26, p = 0.06) but was statistically correlated with sural SNAP decrease rate (r = 0.29, p = 0.04). The sural-sparing pattern phenomenon was the most commonly discovered phenomenon in very early stage patients (OEI ≤4 days), followed by patients with 4< OEI ≤10 days, ultimately found in patients with OEI > 10 days. Conclusions: We suggest performing neurophysiological examination as soon as possible for suspected GBS patients, particularly focusing on multi-spots inspection of ulnar and peroneal nerves, and paying close attention to sural-sparing patterns.

Sign in / Sign up

Export Citation Format

Share Document