Very Early Neurophysiological Study in Guillain-Barre Syndrome

2018 ◽  
Vol 80 (1-2) ◽  
pp. 100-105 ◽  
Author(s):  
Jiaoting Jin ◽  
Fangfang Hu ◽  
Xing Qin ◽  
Xuan Liu ◽  
Min Li ◽  
...  
Keyword(s):  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Tibial Nerve ◽  
Early Stage ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Sensory Nerves ◽  
Motor Nerve Conduction ◽  
Abnormal Rate ◽  
Motor Nerves

Purpose: The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. Methods: We prospectively recruited patients with a diagnosis of GBS discharged from First Affiliated Hospital of Xi’an Jiaotong University and Xi Jing Hospital. Patients were classified into 3 groups according to the onset of symptoms to electromyography examination interval (OEI). The neurophysiological findings were carried out using standard procedures. All patients were examined by the same experienced neurophysiologist. Results: There were not significant group differences in abnormal rate, distal motor latency (DML), motor nerve conduction velocity (MNCV), F response (FR), compound muscle action potential (CMAP), conduction block (CB), sensory nerve action potential (SNAP), and sensory nerve conduction velocity among OEI ≤4 days, 4< OEI ≤10 days, and OEI > 10 days groups. Motor nerves were more affected than sensory nerves in neurophysiological presentation in very early stage patients. The difference of motor nerves and sensory nerves was statistically significant in lower limbs, but was not in upper limbs. In motor nerve conduction studies, the abnormal rate of DML, MNCV, FR, CB was more common seen in ulnar and peroneal nerve than median and tibial nerve, the abnormal rate of CMAP was the same in ulnar, median, peroneal and tibial nerve. In sensory nerve conduction studies, the abnormal rate of ulnar nerve and median nerve was higher than the superficial peroneal nerve and sural nerve. The OEI was not correlated with the SNAP decrease rate of median (r = 0.10, p = 0.23) and ulnar (r = 0.26, p = 0.06) but was statistically correlated with sural SNAP decrease rate (r = 0.29, p = 0.04). The sural-sparing pattern phenomenon was the most commonly discovered phenomenon in very early stage patients (OEI ≤4 days), followed by patients with 4< OEI ≤10 days, ultimately found in patients with OEI > 10 days. Conclusions: We suggest performing neurophysiological examination as soon as possible for suspected GBS patients, particularly focusing on multi-spots inspection of ulnar and peroneal nerves, and paying close attention to sural-sparing patterns.

scholarly journals Effect of Neurodynamic Mobilisation Plus Core Stability on Pain and Motor Nerve Conduction Velocity in Athletes with Lumbar Radiculopathy

2021 ◽  
Vol 28 (3) ◽  
pp. 3-7
Author(s):  
Rashmi Gupta ◽  
Shalini Sharma ◽  
Raj Kumar Sharma ◽  
Saurabh Sharma
Keyword(s):  
Outcome Measures ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Tibial Nerve ◽  
Motor Nerve ◽  
Motor Nerve Conduction Velocity ◽  
Core Stability ◽  
Lumbar Radiculopathy ◽  
Motor Nerve Conduction

Abstract Introduction. Lumbar radiculopathy (LR) is a common debilitating disorder of neuromuscular origin that affects athletes. Material and Methods. This study was a parallel group design and a total of 24 clinically diagnosed athletes with LR were recruited for the study and randomly assigned to one of the two groups, i.e. neurodynamic mobilisation plus core stability group (NDS plus CS) and core stability group only (CS). NDS plus CS underwent neural mobilisation of the tibial nerve and core stability exercises, while CS group performed core stability for a total of 14 sessions on alternate days. The outcome measures of motor nerve conduction velocity (m NCV) of the tibial nerve and pain intensity were recorded before the start of the intervention, at midpoint (7th session) and at the end of the intervention (14th session). Results. Baseline scores of pain and m NCV (NDS plus CS: 6.75 ± 0.62, 38.10 ± 7.21 and CS: 6.58 ± 0.79, 38.92 ± 6.37) were non-significant. The outcome measures improved significantly during treatment in NDS plus CS group (baseline to 7th session, 7th to 14th session and overall mean change for pain and m NCV was found to be 4.74 ± 0.37 and -6.43 ± 3.08, respectively. Non-significant improvement was reported for CS group. Two-way repeated measures (2 x 3) ANOVA was used to analyse the change in the outcome measures and revealed that NDS plus CS group showed statistically significant main effects for group on pain level (F (2, 5.34) = 0.89, p < 0.001 and m NCV (F (2, 5.21) = 0.40, p < 0.03. Significant time and group x time interaction effects were also found. Conclusions. The findings of the study revealed that neurodynamic mobilisation plus core stability were found effective in improving pain level and motor nerve conduction velocity of the tibial nerve in athletes with lumbar radiculopathy.

scholarly journals Reference Values of Sensory and Motor Nerve Conduction for Patients of a Fourth Level Hospital in Bogotá, Colombia

2020 ◽  
Vol 61 (4) ◽  
Author(s):  
Carolina García Alfonso ◽  
Nancy Molina ◽  
Sonia Patricia Millán Pérez
Keyword(s):  
Median Nerve ◽  
Ulnar Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Peroneal Nerve ◽  
Tibial Nerve ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Motor Nerve Conduction ◽  
Significant Difference

Objective: To establish normal values of motor and sensory nerve conductions and late responses for the electrodiagnostic laboratory of the hospital universitario San Ignacio. Materials and Methods: Sensory and motor nerve conduction studies were performed on 77 healthy volunteers between 18 and 65 years old, for a total of 154 analyzes, using a standardized technique for measurement. Results: Motor nerve conduction. For the median nerve the latency ≤4.2ms, amplitude ≥3.1mV and conduction velocity ≥50.8m/s. In the ulnar nerve the latency ≤3.6ms, amplitude ≥4.6mV and conduction velocity ≥49m/s. Tibial nerve latency ≤4.4ms, amplitude ≥5mV and conduction velocity ≥41m/s. Peroneal nerve latency ≤4.8ms, amplitude ≥1.6mV and conduction velocity ≥42m/s. Sensory nerve conduction. For the median nerve the latency ≤2.8ms and conduction velocity ≥45m/s. In the ulnar nerve the latency ≤2.7ms and conduction velocity ≥46m/s. Sural nerve latency ≤2.2ms and conduction velocity ≥41m/s. A Shapiro Wilk test was performed, finding that the amplitude parameters for sensory nerve conductions did not follow a normal distribution, so percentile analysis was performed. Only sex showed a statistically significant difference for the parameters of tibial nerve amplitude (p = 0.0099) being greater in women, and latency of the peroneal nerve (p = 0.0091) being greater in men. Conclusion: Normal parameters were established for motor and sensory nerve conductions and late responses for the electrodiagnostic laboratory of the hospital universitario San Ignacio, which mostly correlate with the current reference data, with certain differences that could be related with height and sex, however, additional studies are required to establish this difference.

Neurophysiological correlates of senile dementia: I. Motor and sensory nerve conduction velocity

1970 ◽  
Vol 1 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Raymond Levy ◽  
Anthony Isaacs ◽  
Gail Hawks
Keyword(s):  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Rating Scale ◽  
Senile Dementia ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Psychological Tests ◽  
Control Group ◽  
Motor Nerve Conduction

SUMMARYThis paper describes an investigation into the relationship between senile dementia and slowing of peripheral nerve conduction velocity. Twenty-eight demented patients and 19 controls were studied. Each patient was rated clinically and given a battery of simple psychological tests in addition to the physiological recordings. The results were as follows: (1) Motor nerve conduction was slower in the demented group than in the control group but this difference was not significant. (2) When subjects were divided according to their dementia score, those with scores above 7 were found to have motor nerve conductions which were significantly slower than those with scores of 7 or less. (3) There was a significant correlation between the severity of the dementia as measured by the rating scale and the psychological tests and the degree of slowing of motor nerve conduction. (4) In those patients who were retested after one year, increase in dementia was significantly correlated with a further slowing of conduction in motor nerves. (5) The possible role of vitamin deficiency was investigated in a small sub-group of demented patients. Deficiencies of thiamine, nicotinic acid, and vitamin B12were not thought to be important but some patients had low folate levels. The significance of these results is discussed.

Control of Uremic Neuropathy by Equilibrium Peritoneal Dialysis

1984 ◽  
Vol 7 (2) ◽  
pp. 97-100 ◽  
Author(s):  
U. Buoncristiani ◽  
G. Mazzotta ◽  
C. Carobi ◽  
V. Gallai ◽  
M. Cozzari ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Motor Nerve Conduction Velocity ◽  
Lower Limbs ◽  
Motor Nerve Conduction ◽  
Extracorporeal Dialysis

Motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNVC) and distal motor latencies times (DMLT) were evaluated both in upper and lower limbs in three groups of 15 patients of comparable age, treated respectively by extracorporeal dialysis (HD), continuous ambulatory peritoneal dialysis (CAPD) and combined peritoneal dialysis (CPD) for comparable sufficiently long periods. Moreover, MNCV was monitored longitudinally in two groups of patients shifted from CAPD to HD and vice versa. The results show a significant superiority of peritoneal dialysis and particularly of CAPD with respect to HD in controlling uremic neuropathy.

The application of Sheng-Mai Injection in diabetes mellitus and related complications: a systematic review and meta-analysis

2021 ◽  
Vol 21 ◽  
Author(s):  
Maoyi Yang ◽  
Zhipeng Hu ◽  
Rensong Yue
Keyword(s):  
Diabetes Mellitus ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Tibial Nerve ◽  
Motor Nerve ◽  
Meta Analysis ◽  
Fasting Blood Glucose ◽  
Sensory Nerve ◽  
Motor Nerve Conduction Velocity

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by progressive β cell dysfunction. Sheng-Mai Injection (SMI), a Traditional Chinese medicine preparation, is widely used for DM and related complications. Objective: The study aims to summarize the applications of SMI in DM and related complications by meta-analysis. Methods: Eight databases were searched, and meta-analyses were performed. Results : Fifteen studies, including 1273 participants, were included. All studies and participants are from China. Pooled effects showed that SMI might reduce glycated hemoglobin (MD -0.46%; 95% CI -0.89 to -0.03; P < 0.01), fasting blood glucose (MD -0.83 mmol/L; 95% CI -1.30 to -0.36; P < 0.01), two-hour Postprandial glucose (MD -1.27 mmol/L; 95% CI -1.96 to -0.58; P < 0.01), 24-hour urinary protein (MD -0.28 mg; 95% CI -0.51 to -0.06; P = 0.01), blood urea nitrogen (MD -1.31 mg; 95% CI -2.08 to -0.54; P < 0.05), Scr (MD -2.60; 95% CI -3.43 to -1.77; P < 0.05), ulnar nerve motor nerve conduction velocity (MNCV) (MD 1.45; 95% CI 0.03 to 2.87; P < 0.05) and tibial nerve Sensory nerve conduction velocity (SNCV) (MD 1.84; 95% CI 0.1 to 3.58; P < 0.05). There was no evidence of effect on common peroneal nervous MNCV and SNCV, tibial nerve MNCV, median nerve MNCV and SNCV. Adverse effects included less frequent gastrointestinal reactions, elevated transaminase, leucopenia, fever, and rash. Conclusion: SMI may be effective in DM and diabetic nephropathy. For diabetic peripheral neuropathy, the effectiveness cannot yet be proven considering the inconsistency of the evidence.

scholarly journals Abnormal Nerve Conduction Parameters in Young Diabetic Patients at Diagnosis

2016 ◽  
Vol 5 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Nirmalendu Bikash Bhowmik ◽  
Md Rashedul Islam ◽  
Rumana Habib ◽  
Aminur Rahman ◽  
Zahid Hassan ◽  
...  
Keyword(s):  
Nerve Conduction ◽  
Peroneal Nerve ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Motor Nerve Conduction ◽  
Nerve Action ◽  
Sensory Nerve Action

Background and Objectives: Diabetes in the young patients, less than 30 years of age, usually has sudden onset and severe hyperglycemia who are resistant to ketosis. Taking the advantage of this uniqueness of this group of patients the present study was aimed to evaluate their peripheral nerve functional status, explore its relationship with glycemic status and find out utility of nerve conduction study for detection of neuropathy at diagnosis to introduce timely intervention in the necessary cases.Materials and Methods: A total number of 32 newly diagnosed untreated diabetic patients, age 30 years or less, consecutively attending the BIRDEM Out-patient department were recruited. Age-matched healthy subjects (n=30) with no family history of diabetes served as controls. Motor and sensory conduction velocities (NCV), distal latencies (DL), compound muscle and sensory nerve action potentials (CAMP, SNAP) of ulnar, peroneal and sural nerves were studied following standard protocol. Glucose was determined by glucose-oxidase, Fructosamine by enzymatic colorimetric method.Results: Ulnar motor NCV (m/sec, mean±SD) was significantly slower in diabetic group compared to the controls [58.29±6.88 vs 66.56±6.13; p<0.001]. CAMP [(?v, median] of ulnar nerve was significantly lower in diabetic patients [4.5 vs 5.8; p<0.05]. Motor nerve conduction velocity of peroneal nerve was significantly slower (p<0.0001) in diabetic patients. Peroneal nerve CMAP [?v, median] amplitude showed similar trends [5.5 vs 8.7 p<0.001]. Sural sensory NCV was significantly slower [35.22±14.04 vs 42.38±8.52; p<0.05] in diabetic patients. Peroneal nerve conduction velocity showed significant negative correlation with fasting glucose (r= -0.456, p<0.001). Peroneal motor distal latency showed positive correlation with serum fructosamine value [r=0.439, p<0.05]. Peroneal and ulnar NCV was negatively correlated [p<0.001 and p<0.05 respectively] with fructosamine. Sural sensory nerve action potential was also negatively correlated [r=-0.400 p<0.05]. S. Fructosamine was negatively correlated with sensory ulnar nerve action potential.Conclusion: The result suggest that in the newly diagnosed untreated young diabetics of Bangladesh, abnormalities of nerve conduction parameters are detected early by doing nerve conduction study; motor nerve conduction parameters are affected more than sensory ones. Abnormal nerve conduction parameters seem to be related to degree of hyperglycaemia in early neuropathic patients.Birdem Med J 2015; 5(1): 14-19

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