Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations

Background: Nanosuspension has arisen as a remunerative, lucrative as well as a potent approach to improve the solubility and bioavailability of poorly aqueous soluble drug entities. Several challenges are still present in this approach which need more research. The prime aim of this review is to identify such challenges that can be rectified in the future. Methods: Through this review, we enlighten the recent patents and advancement in nanosuspension technology that utilize the different drug moieties, instruments and characterization parameters. Results: Nanosuspension has been found to possess great potential to rectify the several issues related to poor bioavailability, site-specific drug delivery, dosing frequency, etc. In the past decade, nanosuspension approach has been complementarily utilized to solve the developed grievances, arisen from poorly soluble drugs. But this field still needs more attention to new discoveries. Conclusion: Nanosuspension contributes a crucial role in administering the different drug entities through a variety of routes involving oral, transdermal, ocular, parenteral, pulmonary, etc. with solving the different issues. This review also confirms the significance of nanosuspension in safety, efficacy, and communal as well as the economic expense associated with healthcare.

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Smart Synthetic Polymer Nanocarriers for Controlled and Site-Specific Drug Delivery

Current Topics in Medicinal Chemistry ◽

10.2174/1568026615666150414115852 ◽

2015 ◽

Vol 15 (15) ◽

pp. 1424-1490 ◽

Cited By ~ 8

Author(s):

Paul Balaure ◽

Alexandru Grumezescu

Keyword(s):

Drug Delivery ◽

Synthetic Polymer ◽

Specific Drug ◽

Site Specific ◽

Polymer Nanocarriers

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Self-microemulsion Technology for Water-insoluble Drug Delivery

Current Nanoscience ◽

10.2174/1573413715666190112122107 ◽

2019 ◽

Vol 15 (6) ◽

pp. 576-588 ◽

Cited By ~ 1

Author(s):

Beibei Yan ◽

Yu Gu ◽

Juan Zhao ◽

Yangyang Liu ◽

Lulu Wang ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Aqueous Solubility ◽

Delivery Systems ◽

Poorly Soluble Drugs ◽

New Chemical Entities ◽

Poorly Soluble ◽

Water Insoluble Drug ◽

Semi Solid ◽

Solidification Technology

: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged widely in recent years, which were prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduction of the study of SMEDDS which could effectively tackle the problem of the water-insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

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A palace fit for the future: Desirability in temporal work

Strategic Organization ◽

10.1177/14761270211012021 ◽

2021 ◽

pp. 147612702110120

Author(s):

Siavash Alimadadi ◽

Andrew Davies ◽

Fredrik Tell

Keyword(s):

Real Time ◽

Crucial Role ◽

The Past ◽

Renewal Program ◽

The Future ◽

Depth Study ◽

Future Events ◽

Future Outcomes ◽

Pluralistic Contexts

Research on the strategic organization of time often assumes that collective efforts are motivated by and oriented toward achieving desirable, although not necessarily well-defined, future states. In situations surrounded by uncertainty where work has to proceed urgently to avoid an impending disaster, however, temporal work is guided by engaging with both desirable and undesirable future outcomes. Drawing on a real-time, in-depth study of the inception of the Restoration and Renewal program of the Palace of Westminster, we investigate how organizational actors develop a strategy for an uncertain and highly contested future while safeguarding ongoing operations in the present and preserving the heritage of the past. Anticipation of undesirable future events played a crucial role in mobilizing collective efforts to move forward. We develop a model of future desirability in temporal work to identify how actors construct, link, and navigate interpretations of desirable and undesirable futures in their attempts to create a viable path of action. By conceptualizing temporal work based on the phenomenological quality of the future, we advance understanding of the strategic organization of time in pluralistic contexts characterized by uncertainty and urgency.

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