scholarly journals Vascular Origins of BOLD and CBV fMRI Signals: Statistical Mapping and Histological Sections Compared

2010 ◽  
Vol 4 ◽  
pp. 1-8 ◽  
Author(s):  
Aneurin J Kennerley ◽  
John E Mayhew ◽  
Peter Redgrave ◽  
Jason Berwick
Keyword(s):  
Histological Sections ◽  
Statistical Mapping

Mentha pulegium Aqueous Extract Exhibits Antidiabetic and Hepatoprotective Effects in Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 19 (3) ◽  
pp. 292-301
Author(s):  
Omar Farid ◽  
Naoufel Ali Zeggwagh ◽  
Fadwa EL Ouadi ◽  
Mohamed Eddouks
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Aqueous Extract ◽  
Morphometric Analysis ◽  
Diabetic Rats ◽  
Mentha Pulegium ◽  
Glucose Levels ◽  
Histological Sections ◽  
Blood Glucose Levels ◽  
Liver And Pancreas

Objective: The aim of this work was to evaluate the antihyperglycemic activity of aerial parts aqueous extract (A.P.A.E) of Mentha pulegium (M. pulegium) on blood glucose levels in normal and streptozotocin(STZ)-induced diabetic rat. The glucose tolerance was evaluated in normal rats. Moreover, the histological sections and morphometric analysis at the liver and pancreas have been carried out in this investigation both in normal and STZ-diabetic rats. Methods: The effect of A.P.A.E of M. pulegium (20 mg/kg) on blood glucose levels was investigated in normal and diabetic rats (n=6). Histopathological changes in liver and pancreas were examined under phase contrast microscope and a preliminary screening for various bioactive constituents was realized according to standard methods. Key Findings: Both single and repeated oral administration of A.P.A.E (20 mg/kg) caused a significant reduction in blood glucose levels in STZ-diabetic rats (p<0.0001). The morphometric analysis and histological sections realized in pancreas and liver have showed the beneficial effect of the A.P.A.E in cellular population. According to oral glucose tolerance test (OGTT), the aqueous extract has revealed an improvement of glucose tolerance in normal rat. Furthermore, the preliminary phytochemical screening of A.P.A.E of M. pulegium has demonstrated the presence of various metabolite compounds including polyphenols, flavonoids, terpenoids tannins, cyanidins, sesquiterpenes, and glycosides. Conclusion: We conclude that the A.P.A.E of M. pulegium (20 mg/kg) exhibits a potent antihyperglycemic activity in STZ diabetic rats.

scholarly journals Automatic morphometry of nerve histological sections

2000 ◽  
Vol 97 (2) ◽  
pp. 111-122 ◽  
Author(s):  
E Romero ◽  
O Cuisenaire ◽  
J.F Denef ◽  
J Delbeke ◽  
B Macq ◽  
...  
Keyword(s):  
Histological Sections

scholarly journals Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chenchen Ren ◽  
Xianxu Zeng ◽  
Zhongna Shi ◽  
Chunyan Wang ◽  
Huifen Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Real Time ◽  
Precancerous Lesions ◽  
Diagnostic Value ◽  
Optical Coherence ◽  
Cervical Lesions ◽  
In Vivo Evaluation ◽  
Histological Sections ◽  
Histological Images

AbstractIn this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2–90.7%), a specificity of 84.1% (95% CI 80.3–87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods.

scholarly journals Prediction of Hyperperfusion After Carotid Endarterectomy by Brain SPECT Analysis With Semiquantitative Statistical Mapping Method

Stroke ◽  
2003 ◽  
Vol 34 (5) ◽  
pp. 1187-1193 ◽  
Author(s):  
Kohkichi Hosoda ◽  
Tetsuro Kawaguchi ◽  
Kazunari Ishii ◽  
Satoshi Minoshima ◽  
Yuji Shibata ◽  
...  
Keyword(s):  
Carotid Endarterectomy ◽  
Mapping Method ◽  
Brain Spect ◽  
Statistical Mapping

Dysprosium-enhanced MR imaging for tumor tissue characterization

1997 ◽  
Vol 38 (2) ◽  
pp. 281-286 ◽  
Author(s):  
C. Wang ◽  
A. Sundin ◽  
A. Ericsson ◽  
T. Bach-Gansmo ◽  
A. Hemmingsson ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tissue Characterization ◽  
Tumor Tissue ◽  
Tumor Model ◽  
Human Colon ◽  
Mr Images ◽  
Histological Sections ◽  
Necrotic Tumor ◽  
Before And After ◽  
Weighted Sequences

Purpose: to evaluate dysprosium-enhanced MR imaging for differentiation between morphologically intact and necrotic tumor tissue in a tumor model. Material and Methods: A human colon carcinoma was transplanted subcutaneously into 9 nude (immunodeprived) rats. MR imaging was performed before and after injection of the dysprosium agent Dy-DTPA-BMA. T1-, T2- and T2*-weighted sequences were acquired. the tumors were dissected, histological sections were prepared, and compared with corresponding MR images. Results: in intact tissue, the MR signal intensity in the T2- and T2*-weighted images decreased after Dy injection and the delineation of the intact regions were sharp and corresponded well to the gross histological sections. Conclusion: Dy-enhanced MR imaging facilitated the differentiation between intact and necrotic tumor tissue.

Three-dimensional temporal bone reconstruction from histological sections

2014 ◽  
Vol 128 (5) ◽  
pp. 416-420 ◽  
Author(s):  
N Ahmad ◽  
A Wright
Keyword(s):  
High Resolution ◽  
Temporal Bone ◽  
Personal Computer ◽  
Three Dimensional ◽  
Jugular Bulb ◽  
Chorda Tympani Nerve ◽  
Three Dimensional Model ◽  
Histological Sections ◽  
Volumetric Reconstruction ◽  
Stapes Footplate

AbstractObjective:To produce a high-resolution, three-dimensional temporal bone model from serial sections, using a personal computer.Method:Digital images were acquired from histological sections of the temporal bone. Image registration, segmentation and three-dimensional volumetric reconstruction were performed using a personal computer. The model was assessed for anatomical accuracy and interactivity by otologists.Results:An accurate, high-resolution, three-dimensional model of the temporal bone was produced, containing structures relevant to otological surgery. The facial nerve, labyrinth, internal carotid artery, jugular bulb and all of the ossicles were seen (including the stapes footplate), together with the internal and external auditory meati. Some projections also showed the chorda tympani nerve.Conclusion:A high-resolution, three-dimensional computer model of the complete temporal bone was produced using a personal computer. Because of the increasing difficulty in procuring cadaveric bones, this model could be a useful adjunct for training.

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