Lipid Nanoparticles: A Novel Approach for Brain Targeting

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

Download Full-text

Multivariate Optimization of Rizatriptan Benzoate-Loaded Solid Lipid Nanoparticles for Brain Targeting and Migraine Management

AAPS PharmSciTech ◽

10.1208/s12249-016-0532-0 ◽

2016 ◽

Vol 18 (2) ◽

pp. 517-528 ◽

Cited By ~ 5

Author(s):

Priti Girotra ◽

Shailendra Kumar Singh

Keyword(s):

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Brain Targeting ◽

Multivariate Optimization ◽

Rizatriptan Benzoate ◽

Solid Lipid

Download Full-text

RES and brain targeting stavudine-loaded solid lipid nanoparticles for AIDS therapy

Asian Journal of Pharmaceutics ◽

10.4103/0973-8398.102934 ◽

2012 ◽

Vol 6 (2) ◽

pp. 116 ◽

Cited By ~ 3

Author(s):

PanchaxariM Dandagi ◽

PunitD Patel ◽

AnandP Gadad ◽

AnilKumar Aravapalli

Keyword(s):

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Brain Targeting ◽

Solid Lipid ◽

Aids Therapy

Download Full-text

Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2013.08.011 ◽

2013 ◽

Vol 85 (3) ◽

pp. 488-502 ◽

Cited By ~ 68

Author(s):

Susana M. Martins ◽

Bruno Sarmento ◽

Cláudia Nunes ◽

Marlene Lúcio ◽

Salette Reis ◽

...

Keyword(s):

Intravenous Administration ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Brain Targeting ◽

Solid Lipid ◽

Targeting Effect

Download Full-text

SLN BRAIN TARGETING DRUG DELIVERY FOR CNS: A NOVEL APPROACH

International Research Journal of Pharmacy ◽

10.7897/2230-8407.0509134 ◽

2014 ◽

Vol 5 (9) ◽

pp. 658-662 ◽

Cited By ~ 1

Author(s):

Nitin Merubhai Mori ◽

Navin R Sheth ◽

Vishal P Mendapara ◽

Kalpesh C Ashara ◽

Jalpa S Paun

Keyword(s):

Drug Delivery ◽

Brain Targeting ◽

Novel Approach

Download Full-text

Overcoming analytical challenges to generate data critical to understanding lipid nanoparticle-delivered modified mRNA biodistribution

Bioanalysis ◽

10.4155/bio-2019-0138 ◽

2019 ◽

Vol 11 (21) ◽

pp. 1993-2001 ◽

Cited By ~ 1

Author(s):

Glen Hawthorne ◽

Neil Henderson ◽

Mikko Hölttä ◽

Sima Khan ◽

Johnny Lindqvist ◽

...

Keyword(s):

Lipid Nanoparticles ◽

Sample Collection ◽

Safety And Efficacy ◽

Chemically Modified ◽

Novel Approach ◽

Mrna Therapeutics ◽

Successful Analysis ◽

Processing Steps ◽

Novel Delivery Systems

Aim: Chemically modified mRNA offers a novel approach to treat disease. Due to susceptibility to extracellular nucleases in vivo, dosed modified mRNA therapeutics can benefit from encapsulation within novel delivery systems, such as lipid nanoparticles (LNPs). To understand the holistic effect of dosing LNP-encapsulated modified mRNA therapeutics can require bioanalysis of several components including the mRNA, protein and LNP. Methodology: These components can require bespoke preanalytical strategies to preserve analyte integrity to achieve successful analysis. Here we describe the sample collection, processing steps and bioanalytical technologies that can be used to overcome these challenges. Discussion: Understanding the biodistribution and holistic effects of the different components allow the pharmaceutical industry to evaluate safety and efficacy of modified mRNA therapeutics.

Download Full-text