Multivariate Optimization of Rizatriptan Benzoate-Loaded Solid Lipid Nanoparticles for Brain Targeting and Migraine Management

2016 ◽  
Vol 18 (2) ◽  
pp. 517-528 ◽  
Author(s):  
Priti Girotra ◽  
Shailendra Kumar Singh
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Multivariate Optimization ◽  
Rizatriptan Benzoate ◽  
Solid Lipid

Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Rotation Speed ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Brain Penetration ◽  
Solid Lipid ◽  
Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

RES and brain targeting stavudine-loaded solid lipid nanoparticles for AIDS therapy

2012 ◽  
Vol 6 (2) ◽  
pp. 116 ◽  
Author(s):  
PanchaxariM Dandagi ◽  
PunitD Patel ◽  
AnandP Gadad ◽  
AnilKumar Aravapalli
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Solid Lipid ◽  
Aids Therapy

Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration

2013 ◽  
Vol 85 (3) ◽  
pp. 488-502 ◽  
Author(s):  
Susana M. Martins ◽  
Bruno Sarmento ◽  
Cláudia Nunes ◽  
Marlene Lúcio ◽  
Salette Reis ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Solid Lipid ◽  
Targeting Effect

Solid Lipid Nanoparticles for Brain Targeting

2019 ◽  
pp. 273-298
Author(s):  
M. M. de Araujo ◽  
L. B. Tofani ◽  
I. L. Suzuki ◽  
P. D. Marcato ◽  
M. V. L. B. Bentley
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Solid Lipid

scholarly journals ApoE-Targeting Increases the Transfer of Solid Lipid Nanoparticles with Donepezil Cargo across a Culture Model of the Blood–Brain Barrier

Pharmaceutics ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 38
Author(s):  
Gizem Rüya Topal ◽  
Mária Mészáros ◽  
Gergő Porkoláb ◽  
Anikó Szecskó ◽  
Tamás Ferenc Polgár ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Barrier ◽  
Brain Targeting ◽  
Solid Lipid ◽  
Blood Brain ◽  
Culture Model ◽  
The Brain

Pharmacological treatment of central nervous system (CNS) disorders is difficult, because the blood–brain barrier (BBB) restricts the penetration of many drugs into the brain. To solve this unmet therapeutic need, nanosized drug carriers are the focus of research efforts to develop drug delivery systems for the CNS. For the successful delivery of nanoparticles (NPs) to the brain, targeting ligands on their surface is necessary. Our research aim was to design a nanoscale drug delivery system for a more efficient transfer of donepezil, an anticholinergic drug in the therapy of Alzheimer’s disease across the BBB. Rhodamine B-labeled solid lipid nanoparticles with donepezil cargo were prepared and targeted with apolipoprotein E (ApoE), a ligand of BBB receptors. Nanoparticles were characterized by measurement of size, polydispersity index, zeta potential, thermal analysis, Fourier-transform infrared spectroscopy, in vitro release, and stability. Cytotoxicity of nanoparticles were investigated by metabolic assay and impedance-based cell analysis. ApoE-targeting increased the uptake of lipid nanoparticles in cultured brain endothelial cells and neurons. Furthermore, the permeability of ApoE-targeted nanoparticles across a co-culture model of the BBB was also elevated. Our data indicate that ApoE, which binds BBB receptors, can potentially be exploited for successful CNS targeting of solid lipid nanoparticles.

Lactoferrin bioconjugated solid lipid nanoparticles: a new drug delivery system for potential brain targeting

2015 ◽  
Vol 24 (3) ◽  
pp. 212-223 ◽  
Author(s):  
Indu Singh ◽  
Rajan Swami ◽  
Deep Pooja ◽  
Manish Kumar Jeengar ◽  
Wahid Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Solid Lipid ◽  
New Drug

Potential of solid lipid nanoparticles in brain targeting

2008 ◽  
Vol 127 (2) ◽  
pp. 97-109 ◽  
Author(s):  
Indu Pal Kaur ◽  
Rohit Bhandari ◽  
Swati Bhandari ◽  
Vandita Kakkar
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Solid Lipid

A novel nasal almotriptan loaded solid lipid nanoparticles in mucoadhesive in situ gel formulation for brain targeting: Preparation, characterization and in vivo evaluation

2018 ◽  
Vol 548 (1) ◽  
pp. 609-624 ◽  
Author(s):  
Nancy Abdel Hamid Abou Youssef ◽  
Abeer Ahmed Kassem ◽  
Ragwa Mohamed Farid ◽  
Fatma Ahmed Ismail ◽  
Magda Abd Elsamea EL-Massik ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
In Vivo Evaluation ◽  
In Situ Gel ◽  
Solid Lipid
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