Helminth Therapy: A New Tool for Treatment of Allergic Diseases

2020 ◽  
pp. 25-65
Author(s):  
Dalia S. Ashour
Keyword(s):  
Allergic Diseases ◽  
Helminth Therapy

The beneficial helminth parasite?

Parasitology ◽  
2005 ◽  
Vol 132 (1) ◽  
pp. 1-12 ◽  
Author(s):  
D. M. McKAY
Keyword(s):  
Immune Response ◽  
Immune Status ◽  
Allergic Diseases ◽  
Careful Analysis ◽  
Epidemiological Studies ◽  
Concomitant Disease ◽  
Helminth Infections ◽  
Comprehensive Knowledge ◽  
Helminth Therapy ◽  
Allergic Disorders

There is unequivocal evidence that parasites influence the immune activity of their hosts, and many of the classical examples of this are drawn from assessment of helminth infections of their mammalian hosts. Thus, helminth infections can impact on the induction or course of other diseases that the host might be subjected to. Epidemiological studies demonstrate that world regions with high rates of helminth infections consistently have reduced incidences of autoimmune and other allergic/inflammatory-type conditions. Here I review and assess the possible ways by which helminth infections can block or modulate concomitant disease processes. There is much to be learned from careful analysis of immuno-regulation in helminth-infected rodents and from an understanding of the immune status of acutely and chronically infected humans. The ultimate reward from this type of investigation will likely be a more comprehensive knowledge of immunity, novel ways to intervene in the immune response to alleviate autoimmune and allergic diseases (growing concerns in economically developed areas), and perhaps the development of helminth therapy for patients suffering from specific inflammatory, autoimmune or allergic disorders.

The prevalence of allergic diseases in primary school children in Edirne, Turkey

1997 ◽  
Vol 27 (3) ◽  
pp. 262-269 ◽  
Author(s):  
Z. TOROS SELCUK ◽  
T. CAG-LAR ◽  
T. ENUNLU ◽  
T. TOPAL
Keyword(s):  
Primary School ◽  
School Children ◽  
Allergic Diseases ◽  
Primary School Children

Predictors of Allergic Diseases Among Pregnant Women, Slovak Republic, 1997–1998

2003 ◽  
Vol 15 (01) ◽  
pp. 030-036
Author(s):  
Scott McNabb ◽  
Eva Reichrtova ◽  
Peter Ciznar ◽  
Lubica Palkovicova ◽  
Andrea Adamcakova ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Slovak Republic ◽  
Allergic Diseases

Iron Metabolism in the Human Body and Setting its Hygienic Limits for Drinking Water. Review. Part 2

2020 ◽  
Vol 99 (5) ◽  
pp. 504-508
Author(s):  
Natalija A. Egorova ◽  
N. V. Kanatnikova
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Iron Overload ◽  
Iron Metabolism ◽  
Subcutaneous Tissue ◽  
Allergic Diseases ◽  
The Body ◽  
Urogenital System ◽  
High Iron Content ◽  
Labile Iron Pool

Iron is an assential element for the growth, division, differentiation and functioning of any cell in the body. Iron is virtually important for human and danger at the same time, because with excessive accumulation it causes oxidative stress with formation of highly active oxygen radicals and reactive form of nitrogen that can destroy cell membranes, proteins, nucleic acids, reduce cell viability, with, according to modern concepts, can contribute to the development of many diseases (cardiovascular, rheumatic, gastrointestinal, neurodegenerative, oncological, metabolic and others), and also accelerate the aging process. Part 1 of this review discussed the issues of iron metabolism in human, including its regulation at the cellular and systemic levels, the intake, transport, use, accumulation and export of iron in cells, the role of the labile iron pool in the cytoplasm of cells and plasma non-transferrin bound iron. Data are provided on the causes, frequency and significance of iron overload in the formation of free radicals and the development of oxidative stress. Part 2 of the review provides information on diseases associated with iron overload as well as information on ferroptosis - a new type of iron-dependent regulated cell death. Attention is paid to the works of domestic authors, where it was found that prolonged use of drinking water with a high iron content is unfavorable for the population and leads to an increase in the overall incidence, the development of the diseases of the blood, skin and subcutaneous tissue, musculoskeletal system, digestive system, urogenital system, and allergic diseases. Separate publications are cited on the possibility of a negative effect of iron at concentrations in water of 0.3 mg/l and lower. The material of the review emphasizes the preventive significance of caution attitude to regulating iron in the water in the Russian Federation, where 1/3 of the population uses iron-containing water for drinking, and substantiate the feasibility of establishing a hygienic limit for iron in water not higher than 0.3 mg/l.

The prevalence of allergic diseases -The prevalence of atopic disease is decreasing・ from the surveillance in Himeji-

2014 ◽  
Vol 28 (1) ◽  
pp. 50-57
Author(s):  
Fumitake Kurosaka ◽  
Kazuta Shimizu ◽  
Katsumi Oka ◽  
Shigeta Shimizu ◽  
Hironobu Takahashi ◽  
...  
Keyword(s):  
Allergic Diseases ◽  
Atopic Disease
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