scholarly journals Mesenchymal Stem Cell (MSC) Transplantation in Patients with Amyotrophic Lateral Sclerosis (ALS): Is there a “Responder Population”?

2018 ◽  
Vol 09 (03) ◽  
Author(s):  
Tomasz Siwek ◽  
Wojciech Maksymowicz ◽  
Monika Barczewska ◽  
Aukasz Grabarczyk ◽  
Mariusz Sowa ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Lateral Sclerosis

PO6.12 Mesenchymal Stem Cell as a Neuroprotective Therapy in Patients with Amyotrophic Lateral Sclerosis

2009 ◽  
Vol 120 ◽  
pp. S63
Author(s):  
Hee-Kyung Park ◽  
Hyun Young Kim ◽  
Seong-Ho Koh ◽  
Young Joo Lee ◽  
Kyu-Yong Lee ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Neuroprotective Therapy ◽  
Lateral Sclerosis

scholarly journals Treating amyotrophic lateral sclerosis with a bone marrow derived mesenchymal stem cell extracellular vesicles - A case report

2021 ◽  
Vol 2 (2) ◽  
pp. 167-171
Author(s):  
Joshua James Crose
Keyword(s):  
Bone Marrow ◽  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Case Report ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicles ◽  
Treatment Options ◽  
Future Studies ◽  
Functional Scores ◽  
Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a terminal neurodegenerative disease with only a few minimally effective treatment options. This study treats a patient with Spinal ALS with Bone Marrow Derived Mesenchymal Stem Cell Extracellular Vesicles (BM-MSCEVs) to slow or stop the progress of the disease. After 2 months and 4 treatments, the patient demonstrated improvement in ALS functional scores and most physical exam findings. BM-MSCEVs demonstrate the ability to effectively treat Spinal ALS in this study and open the door for future studies.

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