Multiple myeloma (MM) is typically characterized by neoplastic proliferation of plasma cells in the bone marrow and can
result in extensive skeletal destruction. Involvement of skull base is extremely rare, especially sphenoid bone. We report in
this work the case of a 62-year-old woman, who presented with a sphenoid relapse of multiple myeloma treated with radiation therapy, with
signicant clinical improvement and almost complete disappearance of the sphenoid metastasis. We shed light, through this case, on the rarity of
sphenoid metastases in multiple myeloma and on the role of radiotherapy in the management of this type of location.
