Kondeti Ramudu Shanmugam
◽
Bhasha Shanmugam
◽
Gangigunta Venkatasubbaiah
◽
Sahukari Ravi
◽
Kesireddy Sathyavelu Reddy
Background :
Diabetes is a major public health problem in the world. It affects each and every part of the
human body and also leads to organ failure. Hence, great progress made in the field of herbal medicine and diabetic
research.
Objectives:
Our review will focus on the effect of bioactive compounds of medicinal plants which are used to treat
diabetes in India and other countries.
Methods:
Information regarding diabetes, oxidative stress, medicinal plants and bioactive compounds were collected
from different search engines like Science direct, Springer, Wiley online library, Taylor and francis, Bentham Science,
Pubmed and Google scholar. Data was analyzed and summarized in the review.
Results and Conclusion:
Anti-diabetic drugs that are in use have many side effects on vital organs like heart, liver, kidney
and brain. There is an urgent need for alternative medicine to treat diabetes and their disorders. In India and other
countries herbal medicine was used to treat diabetes. Many herbal plants have antidiabetic effects. The plants like ginger,
phyllanthus, curcumin, aswagandha, aloe, hibiscus and curcuma showed significant anti-hyperglycemic activities in
experimental models and humans. The bioactive compounds like Allicin, azadirachtin, cajanin, curcumin, querceitin,
gingerol possesses anti-diabetic, antioxidant and other pharmacological properties. This review focuses on the role of
bioactive compounds of medicinal plants in prevention and management of diabetes.
Conclusion:
Moreover, our review suggests that bioactive compounds have the potential therapeutic potential against
diabetes. However, further in vitro and in vivo studies are needed to validate these findings.
In Silico Molecular Docking on Bioactive Compounds from Indian Medicinal Plants against Type 2 Diabetic Target Proteins: A Computational Approach