Relationship between interleukin 4 gene promoter polymorphisms and cutaneous Leishmaniasis cases in North Eastern Iran

AIM: The aim of this study was to determine the correlation between interleukin-4 (IL-4) gene promoter polymorphisms with thyrotropin receptor antibody (TRAb) and transforming growth factor-β (TGF-β). METHODS: This study was conducted from August 2015 until December 2015 in the internal medicine department in Dr. M. Djamil Hospital, Padang, West Sumatera, Indonesia. Graves’ disease was confirmed by measuring free thyroxine, thyroid-stimulating hormone, and TRAb. We examined that IL-4 promotor gene polymorphism was examined with a polymerase chain reaction. Graves’ disease serum patients will be used to check levels of TGFβ and TRAb antibodies using the enzyme-linked immunoassay method. RESULTS: There are 15 patients in this study. The average of age in patients group is 40.87 (11.23) years. The number of female patients in this study is more than male patients, with the percentage of women are 73.3%, and men are 26.7%. The sequencing examination on IL-4 gene promoter resulted in 2 single nucleotide polymorphism motifs, which are rs2243250 and rs2070847. The mean TRAb level in wild type and mutant group is 6.77 (5.73) IU/L and 4.66 (3.91) IU/L, respectively. The mean TGF-β levels in wild type and mutant group are 1168.89 (438.91) pg/mL and 1114.79 (296.02) pg/mL, respectively. Statistical tests showed no association between IL-4 gene promoter polymorphisms with TRAb and TGF-β levels (p > 0.05). CONCLUSION: There is no correlation between IL-4 gene promoter polymorphisms with TRAb and TGF-β.

Download Full-text

THE ROLE OF INTERLEUKIN-4 GENE PROMOTER POLYMORPHISMS IN GRAVES’ DISEASE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i11.39151 ◽

2020 ◽

pp. 73-75

Author(s):

RAVEINAL RAVEINAL ◽

ERYATI DARWIN ◽

EVA DECROLI ◽

JAMSARI JAMSARI

Keyword(s):

Statistical Tests ◽

Gene Promoter ◽

Normal Subjects ◽

Promoter Polymorphism ◽

Interleukin 4 ◽

Control Group ◽

Graves Disease ◽

Promoter Polymorphisms ◽

And Control

Objective: This study was conducted to prove the role of interleukin-4 gene promoter polymorphisms in Graves’ disease patients in M Djamil General Hospital Padang, Indonesia. Methods: This study was conducted from August 2015 until December 2015 in the Internal Medicine Department in Dr. M. Djamil Hospital, Padang, West Sumatera, Indonesia. This study involved 15 patients with Graves’ disease and 15 normal subjects. We examined that IL-4 promoter gene polymorphism was examined with PCR. Results: Sequencing examination on IL-4 gene promoter resulted in 2 Single Nucleotide Polymorphism (SNP) motifs, which is rs2243250 and rs2070847. IL-4 SNP gene promoter polymorphisms rs2243250 and rs2070847 were found in both patient and control groups. TT is homozygous SNP polymorphisms. CT is heterozygous SNP polymorphisms. CC is wild type or no mutation SNP polymorphisms. Based on statistical tests, no difference in rs2243250 and rs2070847 SNP polymorphisms was found between patient and control group (p > 0.05). Conclusion: This study observed no difference in interleukin-4 gene promoter polymorphism between Graves’ disease patients and control group.

Download Full-text

Interleukin-10 Gene Promoter Polymorphisms and Susceptibility to Asthma: Systematic Review and Meta-analysis

Biochemical Genetics ◽

10.1007/s10528-021-10056-9 ◽

2021 ◽

Author(s):

Danyal Imani ◽

Navid Dashti ◽

Arash Parvari ◽

Sajad Shafiekhani ◽

Fatemeh Alebrahim ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Gene Promoter ◽

Interleukin 10 ◽

Promoter Polymorphisms

Download Full-text

Estimation of sediment load and erosion of different geological units: A case study from a basin of north-eastern Iran

Journal of Mountain Science ◽

10.1007/s11629-020-6570-9 ◽

2021 ◽

Vol 18 (6) ◽

pp. 1591-1608

Author(s):

Maryam Tajbakhshian ◽

Abolfazl Mosaedi ◽

Mohamad Hosein Mahmudy Gharaie ◽

Sayyed Reza Moussavi Harami

Keyword(s):

Sediment Load ◽

Eastern Iran ◽

North Eastern ◽

Geological Units

Download Full-text

A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage

Fertility and Sterility ◽

10.1016/j.fertnstert.2013.02.019 ◽

2013 ◽

Vol 99 (7) ◽

pp. 1930-1936.e6 ◽

Cited By ~ 10

Author(s):

Kristiina Rull ◽

Ole Bjarne Christiansen ◽

Liina Nagirnaja ◽

Rudi Steffensen ◽

Tõnu Margus ◽

...

Keyword(s):

Recurrent Miscarriage ◽

Gene Promoter ◽

Promoter Polymorphisms

Download Full-text

Involvement of Il-10 Gene Promoter Polymorphisms in the Susceptibility for Childhood Asthma

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2005.12.1281 ◽

2006 ◽

Vol 117 (2) ◽

pp. S325

Author(s):

M. Sohn ◽

H. Yang ◽

K. Kim

Keyword(s):

Childhood Asthma ◽

Gene Promoter ◽

Promoter Polymorphisms

Download Full-text

Preliminary Report on Stone Age Reconnaissance in north-eastern Iran

Proceedings of the Prehistoric Society ◽

10.1017/s0079497x00015176 ◽

1964 ◽

Vol 30 ◽

pp. 382-399 ◽

Cited By ~ 7

Author(s):

C. B. M. McBurney

Keyword(s):

Preliminary Report ◽

British Museum ◽

Primary Objective ◽

Climatic Data ◽

Middle Palaeolithic ◽

Upper Palaeolithic ◽

Upper Pleistocene ◽

Eastern Iran ◽

North Eastern ◽

The One

The following is a preliminary report on the results achieved during approximately six weeks' archaeological fieldwork in north-eastern Iran in July and August 1963. The primary objective was to explore the area for traces of the local Upper Pleistocene cultural sequence, and in particular to establish if possible the date and character of the local Upper Palaeolithic. In the event no traces of Upper Palaeolithic were obtained. However, a start was made towards defining the problem by the discovery of two well-stratified deposits, the one yielding a Middle Palaeolithic (Mousterian) industry with distinctive regional affinities, and the other an early Post-glacial Mesolithic industry. Reliable samples were obtained for defining the statistical properties of both, together with carbon samples, traces of vertebrate fauna, and some other climatic data.Representative collections were lodged with the Musée Iran Bastan at Teheran; and the expedition's share is to be offered in part to the Museum of Archaeology and Ethnology in Cambridge and in part to the British Museum. The expedition was financed mainly by a grant from the British Academy, supplemented by further grants from the Crowther-Beynon Fund and the British Museum.

Download Full-text