scholarly journals Understanding Vestibular Information Processing in Velocity-Storage Circuit and Application to Interpreting Clinical Manifestation of Vestibular Disorders

2021 ◽  
Vol 20 (3) ◽  
pp. 81-92
Author(s):  
Jeong-Yoon Choi
Keyword(s):  
Information Processing ◽  
Functional Significance ◽  
Clinical Symptoms ◽  
Vestibular Nucleus ◽  
Rotational Velocity ◽  
Velocity Storage ◽  
Vestibular Disorders ◽  
Vestibular Information ◽  
Symptoms And Signs ◽  
Gravity Direction

The velocity-storage circuit comprised of bilateral vestibular nucleus complexes, commissural fiber, and nodulus and uvula functions in refining the raw vestibular signal to estimate rotational velocity, gravity direction, and inertia. In this review, we pursued the functional significance of this velocity-storage circuit and how this physiologic knowledge could help us understand the clinical symptoms and signs of patients with vestibular disorders.

scholarly journals Development of a closed-loop neural prosthesis for vestibular disorders

2010 ◽  
Vol 20 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Giovanna Di ◽  
W. Gong ◽  
C. Haburcakova ◽  
V. Kögler ◽  
J. Carpaneto ◽  
...  
Keyword(s):  
Closed Loop ◽  
Inertial Sensors ◽  
Rotational Velocity ◽  
Neural Prosthesis ◽  
Short Version ◽  
Vestibular Disorders ◽  
Spatial Disorientation ◽  
Vestibular Information ◽  
Sensory Neural ◽  
Visual Blurring

Vestibular disorders can cause severe problems including spatial disorientation, imbalance, nausea, visual blurring, and even cognitive deficits. The CLONS project is developing a closed-loop, sensory neural prosthesis to alleviate these symptoms [1]. In this article, we outline the different components necessary to develop this prosthetic. A short version of this work was presented in the NEUREL 2010 [1]. Conceptually, the prosthesis restores vestibular information based on inertial sensors rigidly affixed to the user. These sensors provide information about rotational velocity of the head; the prosthetic then transfers the information to the vestibular nerve via electrical stimulation. Here we present a project overview, development details, and summarize our progress in animal models and selected human volunteers.

Scoring System for the Diagnosis of COVID-19

2020 ◽  
Vol 13 (1) ◽  
pp. 413-414 ◽  
Author(s):  
Mohamed Farouk Allam
Keyword(s):  
Scoring System ◽  
Clinical Symptoms ◽  
False Negative ◽  
Nasopharyngeal Swab ◽  
Rt Pcr ◽  
Pcr Assay ◽  
Negative Results ◽  
False Negative Results ◽  
Symptoms And Signs

Due to the international spread of COVID-19, the difficulty of collecting nasopharyngeal swab specimen from all suspected patients, the costs of RT-PCR and CT, and the false negative results of RT-PCR assay in 41% of COVID-19 patients, a scoring system is needed to classify the suspected patients in order to determine the need for follow-up, home isolation, quarantine or the conduction of further investigations. A scoring system is proposed as a diagnostic tool for suspected patients. It includes Epidemiological Evidence of Exposure, Clinical Symptoms and Signs, and Investigations (if available). This scoring system is simple, could be calculated in a few minutes, and incorporates the main possible data/findings of any patient.

Scrub typhus (Orientia tsutsugamushi), A rapidly spreading epidemic in Chennai - A standalone lab experience

2016 ◽  
Vol 5 (09) ◽  
pp. 4896
Author(s):  
Sripriya C.S.* ◽  
Shanthi B. ◽  
Arockia Doss S. ◽  
Antonie Raj I. ◽  
Mohana Priya
Keyword(s):  
Scrub Typhus ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Orientia Tsutsugamushi ◽  
The Past ◽  
Igm Elisa ◽  
The Mean ◽  
Specific Symptoms ◽  
Symptoms And Signs

Scrub typhus (Orientia tsutsugamushi), is a strict intracellular bacterium which is reported to be a recent threat to parts of southern India. There is re-emergence of scrub typhus during the past few years in Chennai. Scrub typhus is an acute febrile illness which generally causes non-specific symptoms and signs. The clinical manifestations of this disease range from sub-clinical disease to organ failure to fatal disease. This study documents our laboratory experience in diagnosis of scrub typhus in patients with fever and suspected clinical symptoms of scrub typhus infection for a period of two years from April 2014 to April 2016 using immunochromatography and IgM ELISA methods. The study was conducted on 648 patients out of whom 188 patients were found to be positive for scrub typhus. Results also showed that pediatric (0 -12 years) and young adults (20 – 39 years) were more exposed to scrub typhus infection and female patients were more infected compared to male. The study also showed that the rate of infection was higher between September to February which also suggested that the infection rate is proportional to the climatic condition. Statistical analysis showed that the mean age of the patients in this study was 37.6, standard deviation was 18.97, CV % was 50.45. 

scholarly journals Visuo-Vestibular Information Processing by Unipolar Brush Cells in the Rabbit Flocculus

2015 ◽  
Vol 14 (5) ◽  
pp. 578-583 ◽  
Author(s):  
Robert A. Hensbroek ◽  
Tom J. H. Ruigrok ◽  
Boeke J. van Beugen ◽  
Jun Maruta ◽  
John I. Simpson
Keyword(s):  
Information Processing ◽  
Brush Cells ◽  
Vestibular Information ◽  
Unipolar Brush Cells

scholarly journals A rational approach to the diagnosis of polycystic ovarian syndrome during adolescence

2011 ◽  
Vol 55 (8) ◽  
pp. 590-598 ◽  
Author(s):  
Paulina M. Merino ◽  
Ethel Codner ◽  
Fernando Cassorla
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Clinical Symptoms ◽  
Wide Spectrum ◽  
Rational Approach ◽  
Adult Women ◽  
Ovulatory Dysfunction ◽  
Ovarian Morphology ◽  
Key Factor ◽  
Symptoms And Signs ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a lifelong disorder characterized by hyperandrogenism and ovulatory dysfunction, with a wide spectrum of clinical symptoms and signs. Three different sets of diagnostic criteria have been established in order to define this disease in adult women, but there is controversy regarding the use of these criteria in adolescence. During puberty, the adult criteria for ovulatory dysfunction does not seem applicable, because an irregular menstrual pattern and a decreased ovulatory rate is a physiologic event during this period of life. Also, a higher prevalence of polycystic ovarian morphology (PCOM) may be observed during this period, so PCOM is not a useful criterion to define PCOS in young women. These findings suggest that a key factor to diagnose to PCOS during adolescence is hyperandrogenism. In addition, since PCOM is not clearly associated with hyperandrogenism during this period of life, the term "polycystic ovarian syndrome" during adolescence creates confusion and may be misleading.

Regional anesthesia and acute compartment syndrome: principles for practice

2021 ◽  
pp. rapm-2021-102735
Author(s):  
Tim Dwyer ◽  
David Burns ◽  
Aaron Nauth ◽  
Kaitlin Kawam ◽  
Richard Brull
Keyword(s):  
Compartment Syndrome ◽  
Regional Anesthesia ◽  
Clinical Symptoms ◽  
Motor Nerve ◽  
Acute Compartment Syndrome ◽  
Clinical Settings ◽  
Tissue Ischemia ◽  
Orthopedic Surgical Procedures ◽  
Cardinal Symptom ◽  
Symptoms And Signs

Acute compartment syndrome (ACS) is a potentially reversible orthopedic surgical emergency leading to tissue ischemia and ultimately cell death. Diagnosis of ACS can be challenging, as neither clinical symptoms nor signs are sufficiently sensitive. The cardinal symptom associated with ACS is pain reported in excess of what would otherwise be expected for the underlying injury, and not reasonably managed by opioid-based analgesia. Regional anesthesia (RA) techniques are traditionally discouraged in clinical settings where the development of ACS is a concern as sensory and motor nerve blockade may mask symptoms and signs of ACS. This Education article addresses the most common trauma and elective orthopedic surgical procedures in adults with a view towards assessing their respective risk of ACS and offering suggestions regarding the suitability of RA for each type of surgery.

Vestibular disorders and impaired path integration along a linear trajectory

2000 ◽  
Vol 10 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Helen S. Cohen
Keyword(s):  
Acoustic Neuroma ◽  
Vestibular Disorders ◽  
Vestibular Input ◽  
Active Motion ◽  
Eyes Closed ◽  
Acoustic Neuromas ◽  
Vestibular Information ◽  
Lateral Distance ◽  
Eyes Open ◽  
Straight Ahead

The goal of this study was to determine if people use vestibular information to keep track of their positions while walking through a simple course. Subjects were normals and patients with chronic peripheral vestibulopathies – each of whom were tested once – and patients with acoustic neuromas tested pre- operatively and one and three weeks post-operatively. Subjects walked over a straight course, 7.62 m, with their eyes open and then with their eyes closed. The time needed for task performance, the forward distance subjects walked before veering, and the lateral distance subjects veered from the straight ahead were recorded. The angle of veering was then calculated. Normals were able to perform this task easily with eyes open or closed. With eyes closed pre-operative acoustic neuroma subjects walked significantly shorter distances before veering than normals but did not veer significantly more than normals or take longer than normals to perform the task. Chronic vestibulopathy subjects, by contrast, were significantly impaired compared to normals on all measures. With eyes open within a week after acoustic neuroma resection subjects could perform the task as well as normals. With eyes closed, however, post-operative subjects were impaired compared to their own pre-operative levels, but they had returned to their pre-operative levels at the second post-operative test. Ataxia was only weakly correlated to any measures and tumor size was not related to performance. These findings support the hypothesis that vestibular input is used for spatial orientation during active motion.

Sign in / Sign up

Export Citation Format

Share Document