Acute hemorrhagic syndrome by bracken poisoning in cattle in Belgium

In August 2007, two Belgian blue cows which had been on pasture for three months, showed highfever (41.4°C), epistaxis, melena, cutaneous bleeding, a stiff gait and red lesions on the udder. Bloodexamination revealed severe pancytopenia, and bluetongue virus serotype 8 could be demonstratedby PCR. Despite blood transfusion and supportive treatment, both animals died within 6 days afterthe initial symptoms. At necropsy, an explicit case of a blood coagulation disorder was observed.Inspection at pasture, one week later, showed the presence of numerous regenerated young fronds ofPteridium aquilinum. Whereas the stiff gait and the red lesions on the udder were likely bluetonguevirus associated, other symptoms were consistent with acute bracken poisoning (acute hemorrhagicsyndrome). The present report illustrates that also in Belgium, where the density of bracken fern isrelatively low, pastures should be carefully screened for the presence of young fronds.

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COVID-19, neurovascular thrombotic problem and short summary on blood coagulation disorder: a brief review

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-021-00442-w ◽

2022 ◽

Vol 58 (1) ◽

Author(s):

Rujittika Mungmunpuntipantip ◽

Viroj Wiwanitkit

Keyword(s):

Blood Coagulation ◽

Public Health Problem ◽

Coagulation Disorder ◽

Global Public Health ◽

Respiratory Viral Infection ◽

Short Summary ◽

Neurological Problem ◽

Blood Coagulation Disorder ◽

Neurological System ◽

Global Public Health Problem

AbstractCOVID-19 is the present global public health problem. This respiratory viral infection can manifest atypical presentation including neurological presentations. An important neurological problem in COVID-19 is neurovascular thrombosis. The basic pathogenesis of thrombosis in neurological system is explainable by the basic principle of thrombohemostasis. A hypercoagulability is a possible problem seen in some COVID-19 cases. In this brief review, the authors summarize venous and arterial thrombosis of neurovascular system as a complication of COVID-19. The updated pathophysiology of COVID-associated blood coagulation disorder is discussed. In addition, consideration regarding new COVID-19 vaccine related thrombotic adverse event is also raised.

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Placental Protein 19 in Clinical Blood Coagulation Disorder

Perinatal Thrombosis and Hemostasis ◽

10.1007/978-4-431-65871-9_16 ◽

1991 ◽

pp. 155-163

Author(s):

Masaomi Takayama ◽

Keiichi Isaka ◽

Yoshichika Suzuki ◽

Hitoshi Funayama ◽

Yasunobu Suzuki ◽

...

Keyword(s):

Blood Coagulation ◽

Coagulation Disorder ◽

Placental Protein ◽

Blood Coagulation Disorder

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The replantation of the hand part with critical blood coagulation disorder

Burns ◽

10.1016/j.burns.2006.10.234 ◽

2007 ◽

Vol 33 (1) ◽

pp. S101

Author(s):

V. Zvinys ◽

A. Macas ◽

R. Rimdeika

Keyword(s):

Blood Coagulation ◽

Coagulation Disorder ◽

Hand Part ◽

Blood Coagulation Disorder

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Histiocytic/Dendritic Neoplasm with Marked Blood Coagulation Disorder

Annals of Oncology ◽

10.1016/s0923-7534(20)32534-5 ◽

2012 ◽

Vol 23 ◽

pp. xi166

Author(s):

R. Sakai ◽

H. Tsuchihashi ◽

Y. Ishii ◽

W. Yamamoto ◽

H. Takasaki ◽

...

Keyword(s):

Blood Coagulation ◽

Coagulation Disorder ◽

Blood Coagulation Disorder

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Blood coagulation disorder Thrombotic tendency.

Nihon Naika Gakkai Zasshi ◽

10.2169/naika.88.1668 ◽

1999 ◽

Vol 88 (9) ◽

pp. 1668-1678

Author(s):

HIDEHIKO SAITO

Keyword(s):

Blood Coagulation ◽

Coagulation Disorder ◽

Blood Coagulation Disorder ◽

Thrombotic Tendency

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Prominent coagulation disorder is closely related to inflammatory response and could be as a prognostic indicator for ICU patients with COVID-19

Journal of Thrombosis and Thrombolysis ◽

10.1007/s11239-020-02174-9 ◽

2020 ◽

Vol 50 (4) ◽

pp. 825-832 ◽

Cited By ~ 5

Author(s):

Yang Liu ◽

Weibo Gao ◽

Wei Guo ◽

Yang Guo ◽

Maojing Shi ◽

...

Keyword(s):

Blood Coagulation ◽

Total Bilirubin ◽

Prognostic Indicator ◽

Health Concern ◽

Coagulation Disorder ◽

Global Public Health ◽

Icu Patients ◽

Depth Study ◽

Blood Coagulation Abnormality ◽

Blood Coagulation Disorder

Abstract The new outbreak of Coronavirus Disease 2019 (COVID-19) has emerged as a serious global public health concern. A more in-depth study of blood coagulation abnormality is needed. We retrospectively analyzed 147 consecutive patients with COVID-19 who were admitted to three ICUs in Wuhan from February 9th, 2020 to March 20th, 2020. The baseline coagulation and other characteristics were studied. Our results showed that the prolonged PT, FDP, DD were positively correlated with the levels of neutrophils, ferritin, LDH, total bilirubin, multi-inflammation cytokines, and negatively correlated with the lymphocytes level (p < 0.01). The level of ATIII was significantly negatively correlated with the levels of neutrophils, ferritin, LDH, total bilirubin, IL2R, IL6 and IL8 (p < 0.05). The patients in the ARDS group had a more prominent abnormality in PT, FDP, DD and ATIII, while the patients in the AKI group had more prolonged PT, more severe FDP and DD level, more inferior ATIII and Fib level than those in the non-AKI group (p < 0.01). The value of PT, DD and FDP were positively correlated with the classical APACHE II, SOFA and qSOFA scores, while the ATIII was negatively correlated with them (p < 0.001). The high levels of PT, FDP and DD were correlated with in-hospital mortality (p < 0.001). In conclusion, blood coagulation disorder was prominent in ICU patients with COVID-19 and was correlated with multi-inflammation factors. The abnormality of blood coagulation parameters could be an adverse prognostic indicator for ICU patients with COVID-19.

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THE EFFECT OF EARLY BLOOD TRANSFUSION ON THE OUTCOME OF GASTROINTESTINAL HAEMORRHAGE

10.1055/s-0038-1644157 ◽

1987 ◽

Author(s):

S D Blair ◽

S B Javanvrin ◽

C N McCollum ◽

R M Greenhalgh

Keyword(s):

Blood Transfusion ◽

Blood Coagulation ◽

Whole Blood ◽

Randomised Trial ◽

Gastrointestinal Haemorrhage ◽

Clotting Time ◽

Prospective Randomised Trial ◽

Coagulation Tests ◽

To Receive ◽

Upper Gastrointestinal

It has been suggested that mortality due to upper gastrointestinal haemorrhage may be reduced by restricting blood transfusion [1], We have assessed whether this is due to an anticoagulant effect in a prospective randomised trial.One hundred patients with severe, acute gastrointestinal haemorrhage were randomised to receive either at least 2 units of blood during the first 24 hours of admission, or no blood unless their haemaglobin was lessthan 8g/dl or they were shocked. Minor bleeds and varices were excluded As hypercoagulation cannot be measured using conventional coagulation tests, fresh whole blood coagulation was measured by the Biobridge Impedance Clotting Time (ICT). Coagulation was assessed at 24 hour intervals and compared to age matched controls with the results expressed as mean ± sem.The ICT on admission for the transfusion group (n=50) was 3.2±0.2 mins compared to 10±0.2 mins in controls. This hyper-coagulable state was partially reversed to 6.4±0.3 mins at 24 hours (p<0.001). The 50 allocated to receive no blood had a similar ICT on admission of 4.4±0.4 mins but the hypercoagulable state was maintained with ICT at 24 hours of 4.320.4 mins. Only 2 patients not transfused rebled compared to 15 in the early transfusion group (p<0.001). Five patients died, and they were all in the early transfusion group.These findings show there is a hypercoagulable response to haemorrhage which is partially reversed by blood transfusion leading to rebleeding

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