scholarly journals Carotid total plaque area as a marker of asymptomatic lower extremity arterial disease

2021 ◽  
Vol 2 (2) ◽  
pp. 56-61
Author(s):  
V. V. Genkel ◽  
I. I. Shaposhnik ◽  
E. V. Lebedev ◽  
A. O. Salashenko
Keyword(s):  
Lower Extremity ◽  
Carotid Stenosis ◽  
Carotid Atherosclerosis ◽  
Duplex Ultrasound ◽  
Arterial Disease ◽  
Plaque Score ◽  
Plaque Area ◽  
Artery Disease ◽  
Total Plaque Area ◽  
Longitudinal Position

Objective: to examine the prognostic value of ultrasound markers of carotid atherosclerosis in relation to the presence of asymptomatic lower extremity peripheral artery disease (PAD). Materials and Methods: the study included 193 patients with carotid atherosclerosis. All patients underwent duplex ultrasound scanning (DUS) of carotid and lower limb arteries. The carotid plaque score (cPS) was determined as the total height of all plaques in the carotid arteries. The carotid total plaque area (cTPA) was estimated in the longitudinal position, the area of plaque was measured in the manual trace mode.Results: asymptomatic lower extremity PAD was diagnosed in 31.6% of patients. The increase in cTPA, in contrast to cPS and the degree of carotid stenosis, was independent predictor of lower extremity PAD and was associated with an increase in the relative risk of its presence by 6.78 times (95% CI 2.48-18.5; p <0.0001). cTPA ≥42.5 mm2 made it possible to diagnose asymptomatic lower extremity PAD with a sensitivity of 70.2% and specificity of 73.0%. Conclusion: In patients with carotid atherosclerosis among carotid atherosclerosis markers only cTPA, in contrast to cPS and the degree of carotid stenosis, had an independent predictive value regarding the presence of asymptomatic lower extremity PAD.

scholarly journals Retraction Note: Association of severity of coronary artery disease by SYNTAX score (SS) and lower extremity arterial disease by duplex ultrasound (DUS) study—an Indian perspective

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Saumen Nandi ◽  
Anindya Mukherjee ◽  
Dibbendhu Khanra ◽  
Kaushik Biswas
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lower Extremity ◽  
Duplex Ultrasound ◽  
Arterial Disease ◽  
Syntax Score ◽  
Lower Extremity Arterial Disease ◽  
Retraction Notice ◽  
Artery Disease ◽  
Indian Perspective

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s43044-020-00091-z.

scholarly journals RETRACTED ARTICLE: Association of severity of coronary artery disease by SYNTAX score (SS) and lower extremity arterial disease by duplex ultrasound (DUS) study—an Indian perspective

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Saumen Nandi ◽  
Anindya Mukherjee ◽  
Dibbendhu Khanra ◽  
Kaushik Biswas
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lower Extremity ◽  
Indian Subcontinent ◽  
Ankle Brachial Index ◽  
Duplex Ultrasound ◽  
Arterial Disease ◽  
Smoking History ◽  
Syntax Score ◽  
Artery Disease

Abstract Background Coronary artery disease (CAD) and lower extremity artery disease (LEAD) often coexist. Ankle brachial index (ABI) has been shown to be an independent predictor of CAD. Studies have reported correlation of CAD and LEAD on the basis of ABI and also invasive angiography. But rigorous searching did not reveal any similar research where severity of LEAD was assessed by duplex ultrasound (DUS). In this study, we assessed the association of severity and localisation of LEAD by DUS with SYNTAX score (SS). Results A total of 637 subjects above 45 years of age with coronary angiographic confirmation of CAD were studied in this single centre cross-sectional, descriptive and analytical research. High SS was significantly more common in subjects with LEAD (p = 0.04). In the femoro-popliteal segment, total occlusion of arteries was found in significantly more proportion of subjects with high SS. A progressive increase in mean SS was noted across the grades of arterial disease in the femoro-popliteal segment (p = 0.007). 85.2% of the LEAD was in the femoro-popliteal segment, while below-knee arterial disease was present in 98.5% of subjects with LEAD. Hypertension, smoking, history of CVE and presentation with ACS independently increased the risk of LEAD. Conclusion High prevalence of asymptomatic LEAD and association of high SS with LEAD as a whole as well as femoro-popliteal involvement suggests the need for a point of care DUS study (POCUS) since treatment varies with location and extent of disease which cannot be fathomed by ABI alone. Being the largest study on association of CAD and LEAD from Indian subcontinent till date and also the first study to use non-invasive tool as DUS for LEAD assessment while studying its association with CAD makes this a landmark experience.

Gánh nặng xơ vữa động mạch cảnh ở người mắc bệnh động mạch vành sớm

2021 ◽  
Author(s):  
Thanh Huong Truong
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Carotid Stenosis ◽  
Odds Ratio ◽  
Carotid Atherosclerosis ◽  
Multivariate Logistic Regression Analysis ◽  
Lipoprotein Cholesterol ◽  
Premature Coronary Artery Disease ◽  
Viet Nam ◽  
Artery Disease

TÓM TẮT Đặt vấn đề: Dữ liệu xơ vữa động mạch (ĐM) cảnh ở người mắc bệnh động mạch vành sớm (BĐMVS) còn hạn chế tại Việt Nam. Do đó, nghiên cứu này nhằm mục tiêu xác định tỉ lệ xơ vữa ĐM cảnh và các yếu tố liên quan đến tình trạng này ở người mắc BĐMVS tại Việt Nam. Đối tượng, phương pháp nghiên cứu: Đây là nghiên cứu mô tả với 94 người mắc BĐMVS được siêu âm ĐM cảnh. Kết quả: Tình trạng hẹp ĐM cảnh không ý nghĩa và có ý nghĩa quan sát thấy ở 16 (17.0%) và 4 bệnh nhân (4.3%), tương ứng. Phân tích hồi quy logistic đa biến thấy nồng độ lipoprotein cholesterol tỷ trọng thấp (LDL-C) trong máu liên quan độc lập với hẹp ĐM cảnh có ý nghĩa (Odds Ratio = 1.504). Kết luận: Tại Việt Nam, người mắc BĐMVS có tỉ lệ cao bị hẹp ĐM cảnh. Sàng lọc hẹp ĐM cảnh nên được thực hiện cho nhóm bệnh nhân này, đặc biệt là khi có kèm tăng LDL-máu. Từ khoá: Xơ vữa, hẹp động mạch cảnh, bệnh động mạch vành, sớm ABSTRACT BURDEN OF CAROTID ATHEROSCLEROSIS IN PATIENTS WITH PREMATURE CORONARY ARTERY DISEASE Background: Data about carotid atherosclerosis in patients with premature coronary artery disease (PCAD) is still limited in Vietnam. Therefore, this study aims to investigate the prevalence of carotid atherosclerosis in patients with PCAD and factors related to carotid stenosis in these patients in Vietnam. Methods: This is a cross-sectional study that enrolled 94 patients with PCAD. All of patients were screened carotid atherosclerosis using ultrasonography. Results: Non-significant andsignificant carotid stenosiswere observed in 16 patients (17.0%) and 4 patients (4.3%), respectively. Multivariate logistic regression analysis showed that serum low density lipoprotein cholesterol (LDL-C) level was independently related to the presence of carotid stenosis with Odds ratio as 1.504. Conclusions: Prevalence of carotid stenosis is high in patients with PCAD in Vietnam. Screening of carotid stenosis should be recommended in these patients, especially in whom with elevated LDL-C. Key words: Atherosclerosis, carotid stenosis,coronary artery disease, premature.

scholarly journals Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area

2008 ◽  
Vol 28 (10) ◽  
pp. 1851-1856 ◽  
Author(s):  
Jonathan H. Klein ◽  
Robert A. Hegele ◽  
Daniel G. Hackam ◽  
Marlys L. Koschinsky ◽  
Murray W. Huff ◽  
...  
Keyword(s):  
Carotid Stenosis ◽  
Lipoprotein A ◽  
Plaque Area ◽  
Total Plaque Area

Advances in Management of Carotid Atherosclerosis

1997 ◽  
Vol 12 (2) ◽  
pp. 55-65
Author(s):  
Marc D. Malkoff ◽  
Linda S. Williams ◽  
Jose Biller
Keyword(s):  
Magnetic Resonance Angiography ◽  
Carotid Artery ◽  
Carotid Stenosis ◽  
Carotid Atherosclerosis ◽  
Stroke Risk ◽  
Carotid Artery Disease ◽  
Carotid Angioplasty ◽  
Conventional Angiography ◽  
Artery Disease ◽  
Experimental Treatments

Carotid artery stenosis is a common and potentially treatable cause of stroke. Stroke risk is increased as the degree of carotid stenosis increases, as well as in patients with neurological symptoms referable to the stenosed carotid artery. Carotid stenosis can be quantified by ultrasound imaging, magnetic resonance angiography, or conventional angiography. Medical treatment with platelet antiaggregants reduces stroke risk in some patients; other patients are best treated with carotid endarterectomy. Experimental treatments for carotid stenosis, including carotid angioplasty with or without stenting, are under investigation. We summarize the current literature and provide treatment recommendations for patients with atherosclerotic carotid artery disease.

Carotid total plaque area as a promising marker of asymptomatic peripheral artery disease

2020 ◽  
Vol 315 ◽  
pp. e238-e239
Author(s):  
V.V. Genkel ◽  
A. Kuznetsova ◽  
E. Lebedev ◽  
A. Salashenko ◽  
V. Sumerkina ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Plaque Area ◽  
Artery Disease ◽  
Total Plaque Area

Abstract P043: Higher Levels of CRP and IL-6 are Associated With Femoral Artery Plaque Presence, but Not Plaque Characteristics: The San Diego Population Study (SDPS)

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Natalie Suder ◽  
Emma Barinas-Mitchell ◽  
Matthew Allison ◽  
Michael Criqui ◽  
Joachim Ix ◽  
...  
Keyword(s):  
Population Study ◽  
Femoral Artery ◽  
San Diego ◽  
Smoking Status ◽  
Population Based ◽  
Plaque Burden ◽  
Femoral Arteries ◽  
Plaque Area ◽  
Artery Disease ◽  
Total Plaque Area

Introduction: The potential involvement of c-reactive protein (CRP), interleukin (IL)-6 and intracellular adhesion molecule (ICAM)-1 in the destabilization, erosion, or rupture of arterial plaque, particularly plaques in the lower extremity arteries is not well-established. Thus, we sought to determine whether circulating levels of CRP, IL-6, and ICAM-1 were associated with the presence, burden, and characteristics of femoral artery plaques. Methods: The San Diego Population Study is a prospective, population-based, multi-ethnic cohort of 1103 men and women averaged age 70 at a follow up exam taking place from 2007-11. At this exam, B-mode ultrasound was used to measure plaque presence, burden, and characteristics, including total plaque area (TPA), mean grey-scale median (GSM), and presence of calcification. Plaques were assessed in the left and right superficial and common femoral arteries. Plaque presence was defined as any plaque in any arterial segment, while plaque burden was total number of plaques summed over all four segments. Circulating CRP, ICAM-1, and IL-6 were also measured at this exam. Associations of CRP, IL-6, and ICAM-1 with plaque presence and burden were assessed using logistic and zero-inflated Poisson regression, respectively. Among those with plaque, linear and logistic regression were used to assess associations of the biomarkers with plaque characteristics. All models adjusted for age, sex, race/ethnicity, BMI, BP, statin use, smoking status, diabetes, peripheral artery disease, and chronic kidney disease. Results: Higher circulating CRP was significantly associated with plaque presence with participants in the highest quartile of CRP having 1.8 times higher odds of having femoral plaque compared to those in the lowest quartile. Participants in the highest quartiles of CRP and IL-6 were significantly more likely to have greater plaque burden compared to those in the lowest quartiles (CRP OR=1.64, 95% CI=1.09-2.44; IL-6 OR=1.65, 95%CI=1.06-2.55). No associations were observed between circulating biomarkers and plaque characteristics, including TPA, GSM, or calcification. Conclusions: Higher levels of circulating CRP and IL-6 are associated with greater plaque burden in the femoral arteries of participants in the SDPS; however, these biomarkers do not appear to be associated with characteristics of femoral artery plaques. These results are consistent with findings in the carotid and coronary arteries.

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