ASSOCIATION OF TRANSCRANIAL DIRECT CURRENT STIMULATION AND NEUROFEEDBACK, IN THE DECLARATIONAL MEMORY AND CEREBRAL ARTERIAL FLOW IN UNIVERSITY YOUNG PEOPLE - A RANDOMIZED, DOUBLE-BLIND AND CONTROLLED STUDY PROTOCOL (Preprint)

Declarative Memory ◽

Brain Activity ◽

Low Cost ◽

Memory Function ◽

Well Being ◽

Controlled Study ◽

Double Blind ◽

BACKGROUND The performance of a task depends on ongoing brain activity which can be influenced by attention, excitement or motivation. Scientific studies confirm that mindfulness leads to better performance, health and well-being. However, these cognitive efficiency modulating factors are nonspecific, can be difficult to control, and are not suitable to specifically facilitate neural processing. OBJECTIVE The aim of the present study is to evaluate the effects of tDCS associated with Neurofeedback on declarative memory and cerebral blood flow in university students. METHODS In this work, we will use Transcranial Direct Current Stimulation (tDCS), a low-cost physical resource, easy to apply and few adverse effects, associated with a Neurofeedback resource. This, in turn, has been shown to be a training program capable of improving working memory function. RESULTS The trial began in December 2021 and we are currently performing the statistical analysis for the secondary outcomes. CONCLUSIONS We believe that the resources used in this study can help improve some aspects of declarative memory, since learning and memory processes modify the brain. Strategies to enhance the acquisition, storage and use of information must be able to sensitize (motivate) and involve volunteers in the learning process, thus clarifying their role CLINICALTRIAL https://ensaiosclinicos.gov.br/rg/RBR-4m5j4s

A Randomized Double-Blind Sham-Controlled Study of Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression

Frontiers in Psychiatry ◽

10.3389/fpsyt.2012.00074 ◽

2012 ◽

Vol 3 ◽

Cited By ~ 79

Author(s):

Daniel M. Blumberger ◽

Lisa C. Tran ◽

Paul B. Fitzgerald ◽

Kate E. Hoy ◽

Zafiris J. Daskalakis

Keyword(s):

Major Depression ◽

Direct Current ◽

Controlled Study ◽

Treatment Resistant ◽

Double Blind ◽

Efficacy of fronto-temporal transcranial direct current stimulation for refractory auditory verbal hallucinations in schizophrenia: A randomized, double-blind, sham-controlled study

Schizophrenia Research ◽

10.1016/j.schres.2017.08.047 ◽

2018 ◽

Vol 195 ◽

pp. 475-480 ◽

Cited By ~ 26

Author(s):

Anushree Bose ◽

Venkataram Shivakumar ◽

Sri Mahavir Agarwal ◽

Sunil V. Kalmady ◽

Sonia Shenoy ◽

...

Keyword(s):

Direct Current ◽

Controlled Study ◽

Double Blind ◽

Auditory Verbal Hallucinations ◽

Exploring the neural, behavioural, and clinical effects of transcranial direct current stimulation in patients with a Prolonged Disorder of Consciousness; protocol for a double-blind randomised crossover feasibility study

10.21203/rs.3.rs-15515/v1 ◽

2020 ◽

Author(s):

Davinia Fernández-Espejo ◽

Davide Aloi ◽

Antonio Incisa della Rocchetta ◽

Damon Hoad ◽

Richard Greenwood ◽

...

Keyword(s):

Individual Differences ◽

Feasibility Study ◽

Direct Current ◽

Brain Activity ◽

Brain Structures ◽

Clinical Effects ◽

Disorder Of Consciousness ◽

Double Blind ◽

Abstract Background: Therapeutic options for patients with prolonged disorders of consciousness (PDOC) are very limited, and patients often show little to no progress over time. It is widely recognized that some PDOC patients retain a higher level of cognition that may be apparent on the basis of their external responses, and simply are unable to produce purposeful motor behaviours. This dissociation has been linked to specific impairments in the motor network that lead to a reduction in thalamo-cortical coupling. Here, we will assess whether transcranial direct current stimulation (tDCS) can modulate thalamo-cortical coupling and improve patients’ responsiveness. We will focus on characterising the mechanisms of action of tDCS and the bases for potential individual differences in responsiveness to the stimulation across participants.Methods: This is a multi-centre double-blind randomised crossover feasibility study. It is divided into two streams: (a) MRI stream: 5 PDOC patients will complete 5 anodal, cathodal, and sham stimulation sessions (paired with passive mobilisation of the thumb) in separate weeks. We will measure brain activity and connectivity with functional magnetic resonance imaging and electroencephalography (EEG). We will look at brain structures to assess differences associated with responsiveness. (b) Bedside stream: 10 patients will complete one session of anodal or cathodal stimulation and one session of sham. We will measure brain activity and connectivity with EEG and we will conduct follow up assessments at 3 and 6 months. In both streams we will also look at changes in the clinical profile of patients with the Coma Recovery Scale Revised and in command following behaviour with electromyography and motion tracking. We will assess feasibility on measures of eligibility, recruitment, retention, and completion of tests.Discussion: This feasibility study is the first step towards developing personalised tDCS interventions to restore external responsiveness in PDOC patients. Our results will inform the design of a future trial fully powered for characterising neural, behavioural, and clinical effects of tDCS in PDOC as well as the mechanisms underlying individual differences in responsiveness.

Audiovisual production therapy associated with transcranial direct current stimulation (tDCS) improves naming in patients with non-fluent aphasia: A randomized, double-blind, placebo-controlled study

Brain Stimulation ◽

10.1016/j.brs.2018.12.637 ◽

2019 ◽

Vol 12 (2) ◽

pp. 500

Author(s):

C. Aparecida Pietrobon ◽

R. Marcio Garcia Rocha ◽

M. Felipe Rodrigues de Lima ◽

J. da Silva de Deus ◽

B. Araújo Cavendish ◽

...

Keyword(s):

Direct Current ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Direct Current Stimulation ◽

Fluent Aphasia

Aging, sex and cognitive Theory of Mind: a transcranial direct current stimulation study

Scientific Reports ◽

10.1038/s41598-019-54469-4 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 6

Author(s):

Mauro Adenzato ◽

Rosa Manenti ◽

Elena Gobbi ◽

Ivan Enrici ◽

Danila Rusich ◽

...

Keyword(s):

Social Cognition ◽

Theory Of Mind ◽

Direct Current ◽

Cognitive Abilities ◽

Healthy Aging ◽

Cognitive Theory ◽

Controlled Study ◽

Double Blind ◽

AbstractAging is accompanied by changes in cognitive abilities and a great interest is spreading among researchers about aging impact on social cognition skills, such as the Theory of Mind (ToM). Transcranial direct current stimulation (tDCS) has been used in social cognition studies founding evidence of sex-related different effects on cognitive ToM task in a young people sample. In this randomized, double-blind, sham-controlled study, we applied one active and one sham tDCS session on the medial prefrontal cortex (mPFC) during a cognitive ToM task, including both social (i.e., communicative) and nonsocial (i.e., private) intention attribution conditions, in sixty healthy aging individuals (30 males and 30 females). In half of the participants the anode was positioned over the mPFC, whereas in the other half the cathode was positioned over the mPFC. The results showed that: (i) anodal tDCS over the mPFC led to significant slower reaction times (vs. sham) for social intention attribution task only in female participants; (ii) No effects were found in both females and males during cathodal stimulation. We show for the first time sex-related differences in cognitive ToM abilities in healthy aging, extending previous findings concerning young participants.