Two Cases of Emergency Massive Blood Transfusion in Blood Type-AB Patients: Compatible Red Cell Transfusion with a Different ABO Group after the 2005 Revision of Japanese Practical Guidelines for the Blood Component Therapy

Blood counts in children - Red cell transfusion and blood component therapy—special considerations in neonates and children - Polycythaemia in newborn and childhood - Neonatal anaemia - Anaemia of prematurity - Haemolytic anaemia in the neonate - Congenital red cell defects - Acquired red cell defects - Haemolytic disease of the newborn - Hyperbilirubinaemia - Neonatal haemostasis - Neonatal alloimmune thrombocytopenia - Congenital dyserythropoietic anaemias - Congenital red cell aplasia - Acquired red cell aplasia - Fanconi anaemia - Rare congenital marrow failure syndromes - Neutropenia in childhood - Disorders of neutrophil function - Childhood immune (idiopathic) thrombocytopenic purpura - Haemolytic uraemic syndrome - Childhood cancer and malignant blood disorders - Childhood lymphoblastic leukaemia - Childhood lymphomas - Childhood acute myeloid leukaemia - Childhood myelodysplastic syndromes and chronic leukaemias - Histiocytic syndromes - Haematological effects of systemic disease in children

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Paediatric haematology

10.1093/med/9780199683307.003.0012 ◽

2015 ◽

Author(s):

Drew Provan ◽

Trevor Baglin ◽

Inderjeet Dokal ◽

Johannes de Vos

Keyword(s):

Systemic Disease ◽

Neutrophil Function ◽

Fanconi Anaemia ◽

Blood Component ◽

Red Cell ◽

Haemolytic Disease ◽

Childhood Disorders ◽

Red Cell Aplasia ◽

Blood Component Therapy ◽

Red Cell Transfusion

Blood counts in children - Red cell transfusion and blood component therapy—special considerations in neonates and children - Polycythaemia in newborn and childhood - Neonatal anaemia - Anaemia of prematurity - Haemolytic anaemia in the neonate - Congenital red cell defects - Acquired red cell defects - Haemolytic disease of the newborn - Hyperbilirubinaemia - Neonatal haemostasis - Neonatal alloimmune thrombocytopenia - Congenital dyserythropoietic anaemias - Congenital red cell aplasia - Acquired red cell aplasia - Fanconi anaemia - Rare congenital marrow failure syndromes - Neutropenia in childhood - Disorders of neutrophil function - Childhood immune (idiopathic) thrombocytopenic purpura - Haemolytic uraemic syndrome - Childhood cancer and malignant blood disorders - Childhood lymphoblastic leukaemia - Childhood lymphomas - Childhood acute myeloid leukaemia - Childhood myelodysplastic syndromes and chronic leukaemias - Histiocytic syndromes - Haematological effects of systemic disease in children

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Developing a National Registry for Hemochromatosis

Improving Health Management through Clinical Decision Support Systems - Advances in Healthcare Information Systems and Administration ◽

10.4018/978-1-4666-9432-3.ch007 ◽

2016 ◽

pp. 154-164

Author(s):

Indu Singh ◽

Janelle Guerrero ◽

Michael J. Simmonds

Keyword(s):

Blood Transfusion ◽

Hereditary Hemochromatosis ◽

National Registry ◽

Red Cross ◽

Blood Collection ◽

Healthy Population ◽

Red Cell ◽

Blood Products ◽

Patient Health ◽

Red Cell Transfusion

Hereditary Hemochromatosis (HH) is a disorder where iron and ferritin concentrations in a patient's blood are much higher than normal healthy levels. The main therapeutic intervention for individuals with HH is removing 300-500 mL of blood every few months to maintain ferritin concentration within acceptable ranges. The blood collected during these venesections is usually discarded as there is a belief that blood with high levels of ferritin are not suitable for blood transfusion purposes. Australian Red Cross Blood Services voluntarily collects blood from donors for subsequent use in blood transfusion. Annually more than 700 thousand units are transfused within Australia and there is a constant need for new donors given the significant imbalance between supply and demand of blood products. Besides red cell transfusions, the Red Cross also issues donor blood for development of many other blood products essential for patient health care. The HH blood can currently be used for other blood products if not for red cell transfusion. However, there is evidence to suggest that there is no significant difference between the red cells of the normal healthy population compared to those from HH patients. Australian Red Cross has developed a mobile computer application (High Ferritin “app”) as they have started collecting blood from HH patients. Though there is little or no awareness about the existence and use of this High Ferritin app in general HH population, their doctors and nurses collecting their blood for therapeutic purposes. This chapter describes possibility of saving and utilizing the blood collected from hemochromatosis patients for therapeutic purposes. A national hemochromatosis patients registry, in collaboration with High Ferritin app (HFa) developed by Australian Red Cross Blood Services, accessible to the patients, their doctors and Red Cross Blood Collection Sservices 24 hours a day anywhere in the country can allow the patients to donate the blood collected for therapeutic purposes at any affiliated blood collection center in the country after they automatically get a message either by email or text message after their blood results have been reviewed by their doctor and they are required to go for venesection.

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Can a National All Voluntary Blood Transfusion Service by Adequate Blood Component Therapy Cover Actual and Future Needs of AHF?

Vox Sanguinis ◽

10.1111/j.1423-0410.1976.tb04653.x ◽

1976 ◽

Vol 31 (4) ◽

pp. 296-320 ◽

Cited By ~ 5

Keyword(s):

Blood Transfusion ◽

Blood Component ◽

Future Needs ◽

Blood Transfusion Service ◽

Blood Component Therapy

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Packed red cell blood transfusion practices review in medical oncology unit in a tertiary cancer center, South India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20195187 ◽

2019 ◽

Vol 7 (12) ◽

pp. 4433

Author(s):

Veerendra Angadi ◽

Manjunath Nandennavar ◽

Shashidhar V. Karpurmath ◽

Roshan Jacob ◽

Yamini Donekal

Keyword(s):

Blood Transfusion ◽

Cancer Patients ◽

Intravenous Iron ◽

Red Blood Cell Transfusion ◽

Cancer Center ◽

Red Cell ◽

Retrospective Case ◽

Case Record ◽

Red Cell Transfusion ◽

Oncology Unit

Background: Anaemia is a very common complication in cancer patients. Up to 60% of solid tumor patients and 70-90% of patients receiving myelosuppressive chemotherapy have anaemia. Pathophysiology of anaemia in cancer patients is multifactorial. The treatments for cancer related anaemia include Erythropoietin Stimulating Agents (ESAs), iron supplementing therapies (intravenous iron, oral iron) and blood transfusion. There are various safety concerns regarding usage of ESAs; also, their usage is less in India due to cost factor. There is scant literature regarding blood transfusion practices in patients undergoing chemotherapy.Methods: Patients diagnosed with cancer and patients receiving chemotherapy were included in the study. Retrospective case record review of cancer patients who received chemotherapy between January to March 2019 was done. Type of malignancy, presence of symptoms related to anemia and trigger for packed red cell transfusion were recorded.Results: Among 342 patients received total of 1365 cycles of chemotherapy in this time period. Mean age of patients was 46 years. 46 of the 342 patients received blood transfusion. Only 13% of the patients had symptoms of anemia like weakness and fatigue the average hemoglobin level at which transfusion was given was 6 gm/dL.Conclusions: Packed Red blood cell transfusion was usually administered at Hb <7 gm/dL. Very few patients reported anaemia related symptoms prior to transfusion. No patient received erythropoietin. Further data is needed from other tertiary cancer centres to understand the blood transfusion practices in Indian cancer patients undergoing chemotherapy.

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Anticoagulation, bleeding and blood transfusion practices in Australasian cardiac surgical practice

Anaesthesia and Intensive Care ◽

10.1177/0310057x0703500516 ◽

2007 ◽

Vol 35 (5) ◽

pp. 760-768 ◽

Cited By ~ 13

Author(s):

D. J. Daly ◽

P. S. Myles ◽

J. A. Smith ◽

J. L. Knight ◽

O. Clavisi ◽

...

Keyword(s):

Blood Transfusion ◽

Teaching Hospitals ◽

Red Cell ◽

Transfusion Threshold ◽

Excessive Bleeding ◽

Factors Associated ◽

Antifibrinolytic Therapy ◽

Marked Variability ◽

Clopidogrel Therapy ◽

Red Cell Transfusion

We surveyed contemporary Australasian cardiac surgical and anaesthetic practice, focusing on antiplatelet and antifibrinolytic therapies and blood transfusion practices. The cohort included 499 sequential adult cardiac surgical patients in 12 Australasian teaching hospitals. A total of 282 (57%) patients received red cell or component transfusion. The median (IQR) red cell transfusion threshold haemogloblin levels were 66 (61-73) g/l intraoperative^ and 79 (74-85) g/l postoperatively. Many (40%) patients had aspirin within five days of surgery but this was not associated with blood loss or transfusion; 15% had Clopidogrel within seven days of surgery. In all, 30 patients (6%) required surgical re-exploration for bleeding. Factors associated with transfusion and excessive bleeding include pre-existing renal impairment, preoperative Clopidogrel therapy, and complex or emergency surgery. Despite frequent (67%) use of antifibrinolytic therapy, there was a marked variability in red cell transfusion rates between centres (range 17 to 79%, P <0.001). This suggests opportunities for improvement in implementation of guidelines and effective blood-sparing interventions. Many patients presenting for surgery receive antiplatelet and/or antifibrinolytic therapy, yet the subsequent benefits and risks remain unclear.

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Acute Effects of Blood Transfusion on Spermatogenesis and Pituitary Gonadal axis in Eugonadal Males with Beta Thalassemia Major (pilot study)

Blood ◽

10.1182/blood.v120.21.1027.1027 ◽

2012 ◽

Vol 120 (21) ◽

pp. 1027-1027

Author(s):

Mohamed A. Yassin ◽

Ashraf T Soliman ◽

Ahmed S Elawa ◽

Hanadi Rafii El-Ayoubi ◽

Vincenzo Desanctis

Keyword(s):

Blood Transfusion ◽

Research Funding ◽

Sperm Count ◽

Thalassemia Major ◽

Semen Parameters ◽

Red Cell ◽

Acute Effects ◽

Seminal Parameters ◽

Igf I ◽

Red Cell Transfusion

Abstract Abstract 1027 Objective: To evaluate semen parameters and measure serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T) and insulin-like growth factor-I (IGF-I) concentrations before and 7 days after packed red cell transfusion (PCTx) in young adults with thalassemia major (TM). Design: Prospective study. Setting, Patients, Interventions: We studied the effect of blood transfusion on semen parameters, the endocrine functions in 10 young adults with TM, aged from 17 to 32 years, with full pubertal development (Tanner's stage 5) (euogonadal),and capacity to ejaculate. They were regularly transfused since early childhood and underwent chelation therapy using desferrioxamine which was replaced by deferasirox for the last 4 –5 years. At the time of the study their serum ferritin levels ranged from 500 to 5922 ng/ml (mean2686 ng/ml). Basal serum concentrations of FSH, LH, T and IGF-I were evaluated before and 7 days after packed red cell transfusion (PCTx). Main Outcome Measures and Results: After PCTx significant increase of Hb from 8.7 +/− 0.86 g/dl to 11.1 +/− 0.82 g/dl was associated with increased testosterone (from 16.5 +/− 8 nmol/L to 20 +/− 8.8 nmol/L, IGF-I (from 173 +/− 46ng/ml to 214 +/− 61ng/ml) and gonadotropins' concentrations. Total sperm count increased significantly from 57.8 +/− 38.3 million/ml to 166 +/− 132 million/ml and rapid progressive sperm motility progressive motility increased from 20.6+/− 16.6 % to 79.7 +/− 67.4 %. After PCTx, LH concentrations were correlated significantly with T concentrations (r = 0.434, p < 0.001) and sperm volume and count (r = 0.439 and r = 0.376 respectively, p: 0.01). The increase of IGF-I concentration was correlated significantly with Hb level after PCTx (r = 0.535, p < 0.001) and negatively with ferritin concentration (r = −0.458, p < 0.001). Significant correlation were found between serum T concentrations and semen parameters before and after PCTx including sperm count (r = 0.658 and r = 0.73 respectively, p < 0.001)rapid progressive motility (r = 0.675 and r = 0.758 respectively p < 0.001), and the number of sperms with normal morphology (r = 0.752 and r = 0.834 respectively, p < 0.001) IGF-I levels and seminal parameters. No correlations were found between serum FSH and IGF-I concentrations and seminal parameters. Conclusion: Our study suggests that in thalassemic males blood transfusion is associated with significant acute enhancement of sperm parameters and with an increased concentrations of serum testosterone, LH, FSH and IGF-I. These “acute” effects on spermiogenesis are reached with an unknown mechanism/s and suggest a number of pathways that need further human and/or experimental studies. Disclosures: Yassin: Hamad medical corporation MRC: Employment, Research Funding. Soliman:Hamad medical corporation MRC: Employment, Research Funding. Elawa:Hamad medical corporation MRC: Employment, Research Funding.

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Frequencies of feline blood types in Hungary

Acta Veterinaria Hungarica ◽

10.1556/004.49.2001.4.1 ◽

2001 ◽

Vol 49 (4) ◽

pp. 369-375 ◽

Cited By ~ 13

Author(s):

Nóra Bagdi ◽

Melinda Magdus ◽

E. Leidinger ◽

Judith Leidinger ◽

K. Vörös

Keyword(s):

Blood Transfusion ◽

Blood Group ◽

Diagnostic Method ◽

Type A ◽

Blood Groups ◽

Blood Type ◽

Type B ◽

Blood Types ◽

Type Ab ◽

Transfusion Reactions

Feline blood group determination is done as a routine diagnostic method in numerous countries. Blood transfusion reactions and feline neonatal isoerythrolysis (FNI) can be avoided with the identification of different feline blood groups. The present study is the first investigation in Hungary during which 100 cats have been examined from all over the country. These cats were out of six breeds: European domestic shorthair, Persian mix, Persian, Abyssinian, Siamese and British shorthair. In the Hungarian feline population European domestic shorthair are most common but other breeds also occur. European domestic shorthair, Persian mix, Abyssinian, Siamese and British shorthair individuals all belonged to blood type A (100%). Blood type B was found very rarely and only in Persian cats. One-third of the Persian cats were categorised into blood type B, whilst type AB was not found during the study.

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III.—New Developments in Large-scale Plasma Fractionation

Proceedings of the Royal Society of Edinburgh Section B Biology ◽

10.1017/s0080455x00013187 ◽

1972 ◽

Vol 71 (S1) ◽

pp. s15-s34

Author(s):

J. G. Watt ◽

J. K. Smith ◽

W. Grant ◽

C. Turnbull

Keyword(s):

Side Effects ◽

Blood Transfusion ◽

Large Scale ◽

American Association ◽

Blood Component ◽

Blood Components ◽

Donor Blood ◽

New Developments ◽

Blood Banks ◽

Blood Component Therapy

‘Selective transfusion of appropriate blood components is preferable to the routine use of whole blood.’ (American Association of Blood Banks. Physicians' Handbook of Blood Component Therapy, 1969).The rational use of donor blood in the environment of modern blood transfusion revolves around a series of developments in the field of component therapy. The fractionation of plasma, i.e. the separation of plasma into a series of subdivisions each containing one or other of the constituent proteins in varying degrees of purity and concentration, was one of the first of these developments to become established.Early fractionation of plasma was applied in various ways to the purification of animal antisera; initially to antipneumococcal serum for therapeutic use. These sera frequently provoked reactions in patients until Sabin showed that absorption with Fullers earth could abolish these side-effects by removing complexed molecules.

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