Ground-Glass Nodules on Chest CT as Imaging Biomarkers in the Management of Lung Adenocarcinoma

2011 ◽  
Vol 196 (3) ◽  
pp. 533-543 ◽  
Author(s):  
Jin Mo Goo ◽  
Chang Min Park ◽  
Hyun Ju Lee
Keyword(s):  
Lung Adenocarcinoma ◽  
Chest Ct ◽  
Ground Glass ◽  
Imaging Biomarkers ◽  
Ground Glass Nodules

scholarly journals Diffuse Cystic Metastases in the Lung after Nivolumab Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report

2021 ◽  
pp. 34-38
Author(s):  
Satoshi Muto ◽  
Yuki Ozaki ◽  
Takuya Inoue ◽  
Naoyuki Okabe ◽  
Yuki Matsumura ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Lung Metastases ◽  
Sialyl Lewis X ◽  
Ground Glass ◽  
Cystic Lesions ◽  
Positron Emission ◽  
Ground Glass Nodules

Although diffuse cysts in the lung can be found in many diseases, they are uncommon in metastatic lung adenocarcinoma. They are even more unusual after the administration of immune checkpoint inhibitors. A case of lung adenocarcinoma that developed diffuse cysts in the lungs during treatment with nivolumab is reported. The patient was a 60-year-old woman with postoperative recurrent lung adenocarcinoma in mediastinal lymph nodes and pleural dissemination. After first-line treatment with cisplatin, pemetrexed, and bevacizumab, computed tomography (CT) showed disease progression. Treatment was then switched to nivolumab. After 5 courses of nivolumab, CT showed multiple ground-glass nodules in her lungs. After 4 more courses of nivolumab, the ground-glass nodules increased in size, and cystic air spaces appeared in their centers. The patient did not have any symptoms. Laboratory tests showed no evidence of infection or nivolumab-induced pneumonitis. Sialyl Lewis X-i antigen increased, and positron emission tomography showed abnormal uptake of 18F-fluorodeoxyglucose in these lesions. Considering this evidence, the cystic lesions were diagnosed as multiple lung metastases. Various differential diagnoses should be considered when diffuse cystic lesions are found in the lungs after the administration of immune checkpoint inhibitors.

scholarly journals Lung Adenocarcinoma Manifesting as Pure Ground-Glass Nodules: Correlating CT Size, Volume, Density, and Roundness with Histopathologic Invasion and Size

2017 ◽  
Vol 12 (8) ◽  
pp. 1288-1298 ◽  
Author(s):  
Benedikt H. Heidinger ◽  
Kevin R. Anderson ◽  
Ursula Nemec ◽  
Daniel B. Costa ◽  
Sidhu P. Gangadharan ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Volume Density ◽  
Ground Glass ◽  
Ground Glass Nodules

Computerized texture analysis predicts histological invasiveness within lung adenocarcinoma manifesting as pure ground-glass nodules

2019 ◽  
Vol 60 (10) ◽  
pp. 1258-1264 ◽  
Author(s):  
Yang Yang ◽  
Wei-Wei Wang ◽  
Yan Ren ◽  
Xian-Qiao Jin ◽  
Quan-Dong Zhu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Texture Analysis ◽  
Ground Glass ◽  
Ground Glass Nodules

Computer-Aided Segmentation and Volumetry of Artificial Ground-Glass Nodules at Chest CT

2013 ◽  
Vol 201 (2) ◽  
pp. 295-300 ◽  
Author(s):  
Ernst Th. Scholten ◽  
Colin Jacobs ◽  
Bram van Ginneken ◽  
Martin J. Willemink ◽  
Jan-Martin Kuhnigk ◽  
...  
Keyword(s):  
Chest Ct ◽  
Ground Glass ◽  
Computer Aided ◽  
Ground Glass Nodules

scholarly journals Investigating the association between ground-glass nodules glucose metabolism and the invasive growth pattern of early lung adenocarcinoma

2021 ◽  
Vol 11 (8) ◽  
pp. 3506-3517
Author(s):  
Xiaoliang Shao ◽  
Xiaonan Shao ◽  
Rong Niu ◽  
Zhenxing Jiang ◽  
Mei Xu ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Lung Adenocarcinoma ◽  
Growth Pattern ◽  
Ground Glass ◽  
Invasive Growth ◽  
Ground Glass Nodules
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