scholarly journals Prospects for the use of laser Doppler flowmetry to assess cutaneous blood microcirculation in diabetes mellitus

2021 ◽  
Vol 17 (8) ◽  
pp. 613-618
Author(s):  
Z.O. Shaienko ◽  
O.V. Ligonenko
Keyword(s):  
Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
The State ◽  
Laser Doppler ◽  
Dynamic Monitoring ◽  
Clinical Aspects ◽  
Doppler Flowmetry ◽  
Microcirculatory Bed ◽  
Non Invasive ◽  
Microcirculatory Disorders

The аrticle considers the scientific and clinical aspects of laser Doppler flowmetry (LDF) in the diagnosis of the state of the microcirculatory bed in diabetes mellitus. LDF is a non-invasive quantitative method of microcirculation assessment; its capabilities include the analysis of microcirculatory rhythms and functional testing with different types of provocation tests, which provides a study of the state of regulatory mechanisms of microcirculation. The difficulties with studying the microcirculation are caused by the very small size of microvessels. The prevention and treatment of various microcirculatory disorders is one of the most important problems in medical practice. The findings of some studies suggest that microcirculatory disorders are not only a pathogenetic link in the development of complications, but are also observed in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes mellitus. The use of LDF in scientific researches will make it possible to reveal changes in microcirculatory bed functioning that are characteristic of diabetes mellitus. The possibility of non-invasive quantitative assessment of the state of microcirculatory blood flow in real time and the relative ease of use explains the high popularity of LDF in scientific researches and makes this method promising for use in clinical practice. This method can be of important diagnostic value for the study of the state of different levels of regulation of the microcirculatory tract and dynamic monitoring of the effectiveness of the prescribed treatment. Combined use of LDF to identify the risk of developing diabetic foot syndrome will allow to personify the treatment of diabetes. Among the most promising points of application should be noted the study of microcirculation in the early diagnosis of diabetes and its complications, clarifying the risk of complications, monitoring the effectiveness of treatment. The development of optimal evaluation methods of microcirculation is a prospect for further research.

scholarly journals Laser doppler flowmetry as the advanced non-invasive method of evaluation оf microcirculation status in patients with diabetes mellitus

2021 ◽  
pp. 44-50
Author(s):  
Z. Shaienko
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Practice ◽  
Laser Doppler Flowmetry ◽  
The State ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Non Invasive ◽  
Patients With Diabetes ◽  
Microcirculatory Disorders ◽  
Method Of Evaluation

Currently, the problem of diabetes mellitus (DM) is one of the most important medical and social challenges worldwide. This is primarily due to the widespread prevalence of the disease and tendency to further increase in the incidence of diabetes mellitus.Systemic microcirculatory disorders play an impor­tant role in the pathogenesis of DM complications. They lead to the development of microangiopathy and neuropathy through the primary lesion of vessels involved in the blood supply of the peripheral parts of the nervous system. Currently, less than one-third of physicians recognize signs of peripheral neuropathy associated with diabetes. Untimely diagnosis contributes significantly to high morbidity, disability, and mortality.The authorinvestigates the experience of the use of laser Doppler flowmetry (LDF) in clinical practice as a method of studying the state of the microcirculatory bed in patients with diabetes mellitus.LDF is a non-invasive quantitative method of microcirculation assessment; its capabilities include the analysis of microcirculatory rhythms and functional testing with different types of provocative effects, which provides with investigating the state of regulatory mechanisms of microcirculation. The prevention and treatment of various microcirculatory disorders is one of the most important problems of medical practice. The difficulties of studying the microcirculation are caused by the very small size of microvessels and strong ramification of intra-organic vascular networks. The use of LDF in scientific research will make it possible toreveal the DM-specific changes in microcir­culatory bed functioning. The findings of some studies suggest that microcirculatory disorders are not only a pathogenetic link in the development of complications, but they are also observed in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes. However, the method has not yet become widespread in clinical practice.

Peculiarities of microcirculation in periodont tissues in children of key age groups sufficient type 1 diabetes. Part II

2019 ◽  
Vol 24 (2) ◽  
pp. 108-119 ◽  
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Healthy Children ◽  
Doppler Flowmetry

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low efciency and redistribution of blood flow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

METHOD FOR ANALYSIS OF THE DOPPLER-BROADENED SPECTRA OF LASER RADIATION FOR THE ASSESSMENT OF BLOOD MICROCIRCULATION DISTURBANCES IN DIABETES MELLITUS TYPE 2

2020 ◽  
Vol 4 (1) ◽  
pp. 80-87
Author(s):  
I.O. KOZLOV
Keyword(s):  
Diabetes Mellitus ◽  
Laser Radiation ◽  
Laser Doppler Flowmetry ◽  
Diabetes Mellitus Type 2 ◽  
Feature Space ◽  
Diabetes Mellitus Type ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
New Feature

The article is devoted to the development of laser Doppler flowmetry and analysis of the recorded signal to study the distribution of perfusion over the frequencies of Doppler broadening of laser radiation. The processing algorithm and the necessary technical conditions for the correct registration of the signal are shown. As examples of the proposed method implementation, the data are obtained from a healthy volunteer and a patient with diabetes mellitus type 2 and analyzed. According to the proposed method, processing of recorded data provides a new feature space for data analysis of laser Doppler flowmetry signal.

scholarly journals The condition state of the microcirculatory channel in the skin of patients with Rosacea

2019 ◽  
pp. 22-25
Author(s):  
Хамди Кхаем ◽  
Елена Гортинская
Keyword(s):  
Laser Doppler Flowmetry ◽  
Frequency Characteristic ◽  
The State ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Amplitude Frequency Characteristic ◽  
Condition State

A laser Doppler flowmetry study of the state of the micro­vasculature of the skin in patients with rosacea was per­formed. The amplitude-frequency criteria for assessing dermal circulation are determined. Depth and direction of vascularization disorders are shown. It is proved that the amplitude-frequency characteristic of the state of the micro­vasculature of the skin should be taken into account when choosing the means of therapeutic correction and can serve as one of the criteria for the effectiveness of treatment.

Sign in / Sign up

Export Citation Format

Share Document