LASER DOPPLER FLOWMETRY IN THE ASSESSMENT OF SKIN MICROCIRCULATORY DISORDERS IN PATIENTS WITH DIABETIC POLYNEUROPATHY. PART 2

The prevention and treatment of various microcirculation disorders are one of the most important problems of medical practice. The difficulties of studying the microcirculation are related to the blood vessels small size and extensive branching within organ tissues. At present, various methods of microcirculation assessment using the laser Doppler flowmetry are applied in active clinical practice in our country. The review covers the main methods of laser Doppler flowmetry used for the diagnosis of various microcirculation disorders. The method is based on the determination of tissue blood perfusion by measuring the Doppler frequency shift while tissue is illuminated by a laser beam, followed by the registration of the reflected radiation from moving and stationary tissue components. Microcirculatory oscillation rhythm plays an important role, especially in early diagnosis of many diseases. The loss of certain types of oscillations at laser Doppler flowmetry is interpreted as «spectral narrowing» and serves as a diagnostic criterion for microcirculation deregulation, which is directly related to decreased blood perfusion and tissue hypotrophy. The use of amplitude-frequency analysis of blood flow oscillations can non-invasively evaluate the impact of the various components of microvascular tone, allowing to calculate an index of neurogenic and myogenic tone and bypass index. The amplitude-frequency analysis of the laser Doppler flowmetry spectrum uses normalized parameters determining the maximum amplitude of the blood flow oscillation in different bands, as well as their ratio - microcirculation effectiveness index. Hyperemic, spastic, spastic-atonic, structural and degenerative, congestive and stasic forms of various microcirculation disorders are marked out. Each of these microcirculatory disorders is characterized by a certain ratio of structural and functional changes and changes in blood velocity, as well as impaired barrier function. The main principles of the microcirculatory disorders are described.

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Microcirculatory Bloodstream Malfunctioning in Patients with Natural-Focal Infections

Problems of Particularly Dangerous Infections ◽

10.21055/0370-1069-2013-2-78-79 ◽

2013 ◽

pp. 78-79

Author(s):

O. V. Grachieva ◽

R. A. Sadretdinov

Keyword(s):

Laser Doppler Flowmetry ◽

Q Fever ◽

Laser Doppler ◽

Doppler Flowmetry ◽

Microcirculatory Disorders ◽

Severity Of The Disease

Represented are the results of examination of the 42 patients with Q-fever using laser Doppler flowmetry. Based on the data obtained identified are the skin microcirculatory disorders among the patients depending on their age, gender, severity of the disease, and occurrence of complications. Laser Doppler flowmetry predictors can be used for earlier diagnostics, prognostication, and prophylaxis of complications as well as evaluation of the efficacy as regards an ongoing therapy in Q-fever patients.

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State of some indices of laser doppler flowmetry in norm and in gingivitis in children

Kazan medical journal ◽

10.17816/kazmj70125 ◽

1999 ◽

Vol 80 (4) ◽

pp. 287-290

Author(s):

M. Z. Mirgazizov ◽

N. K. Khamitova ◽

E. V. Mamaeva

Keyword(s):

Blood Flow ◽

Early Diagnosis ◽

Laser Doppler Flowmetry ◽

Capillary Blood ◽

Laser Doppler ◽

Capillary Blood Flow ◽

Doppler Flowmetry ◽

Microcirculatory Disorders

Capillary blood flow of paradont tissue in norm and in children sufferred from chronic generalized gingivitis and paradontosis in slight form is studied. The method of estimating microcirculatory disorders in paradont tissue using laser doppler fluorometry is developed. The prospects of its wide use in stomatology for early diagnosis of disorders of paradont capillary net-work are stressed.

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Laser doppler flowmetry as the advanced non-invasive method of evaluation оf microcirculation status in patients with diabetes mellitus

Clinical endocrinology and endocrine surgery ◽

10.30978/cees-2021-4-44 ◽

2021 ◽

pp. 44-50

Author(s):

Z. Shaienko

Keyword(s):

Diabetes Mellitus ◽

Clinical Practice ◽

Laser Doppler Flowmetry ◽

The State ◽

Laser Doppler ◽

Doppler Flowmetry ◽

Non Invasive ◽

Patients With Diabetes ◽

Microcirculatory Disorders ◽

Method Of Evaluation

Currently, the problem of diabetes mellitus (DM) is one of the most important medical and social challenges worldwide. This is primarily due to the widespread prevalence of the disease and tendency to further increase in the incidence of diabetes mellitus.Systemic microcirculatory disorders play an important role in the pathogenesis of DM complications. They lead to the development of microangiopathy and neuropathy through the primary lesion of vessels involved in the blood supply of the peripheral parts of the nervous system. Currently, less than one-third of physicians recognize signs of peripheral neuropathy associated with diabetes. Untimely diagnosis contributes significantly to high morbidity, disability, and mortality.The authorinvestigates the experience of the use of laser Doppler flowmetry (LDF) in clinical practice as a method of studying the state of the microcirculatory bed in patients with diabetes mellitus.LDF is a non-invasive quantitative method of microcirculation assessment; its capabilities include the analysis of microcirculatory rhythms and functional testing with different types of provocative effects, which provides with investigating the state of regulatory mechanisms of microcirculation. The prevention and treatment of various microcirculatory disorders is one of the most important problems of medical practice. The difficulties of studying the microcirculation are caused by the very small size of microvessels and strong ramification of intra-organic vascular networks. The use of LDF in scientific research will make it possible toreveal the DM-specific changes in microcirculatory bed functioning. The findings of some studies suggest that microcirculatory disorders are not only a pathogenetic link in the development of complications, but they are also observed in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes. However, the method has not yet become widespread in clinical practice.

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Prospects for the use of laser Doppler flowmetry to assess cutaneous blood microcirculation in diabetes mellitus

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.17.8.2021.246793 ◽

2021 ◽

Vol 17 (8) ◽

pp. 613-618

Author(s):

Z.O. Shaienko ◽

O.V. Ligonenko

Keyword(s):

Diabetes Mellitus ◽

Laser Doppler Flowmetry ◽

The State ◽

Laser Doppler ◽

Dynamic Monitoring ◽

Clinical Aspects ◽

Doppler Flowmetry ◽

Microcirculatory Bed ◽

Non Invasive ◽

Microcirculatory Disorders

The аrticle considers the scientific and clinical aspects of laser Doppler flowmetry (LDF) in the diagnosis of the state of the microcirculatory bed in diabetes mellitus. LDF is a non-invasive quantitative method of microcirculation assessment; its capabilities include the analysis of microcirculatory rhythms and functional testing with different types of provocation tests, which provides a study of the state of regulatory mechanisms of microcirculation. The difficulties with studying the microcirculation are caused by the very small size of microvessels. The prevention and treatment of various microcirculatory disorders is one of the most important problems in medical practice. The findings of some studies suggest that microcirculatory disorders are not only a pathogenetic link in the development of complications, but are also observed in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes mellitus. The use of LDF in scientific researches will make it possible to reveal changes in microcirculatory bed functioning that are characteristic of diabetes mellitus. The possibility of non-invasive quantitative assessment of the state of microcirculatory blood flow in real time and the relative ease of use explains the high popularity of LDF in scientific researches and makes this method promising for use in clinical practice. This method can be of important diagnostic value for the study of the state of different levels of regulation of the microcirculatory tract and dynamic monitoring of the effectiveness of the prescribed treatment. Combined use of LDF to identify the risk of developing diabetic foot syndrome will allow to personify the treatment of diabetes. Among the most promising points of application should be noted the study of microcirculation in the early diagnosis of diabetes and its complications, clarifying the risk of complications, monitoring the effectiveness of treatment. The development of optimal evaluation methods of microcirculation is a prospect for further research.

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Diagnostics of Microcirculatory Disorders in Children with Infectious Pathology

Problems of Particularly Dangerous Infections ◽

10.21055/0370-1069-2012-4-86-88 ◽

2012 ◽

pp. 86-88

Author(s):

O. V. Grachieva ◽

G. A. Kharchenko ◽

D. N. Rasskazov ◽

R. A. Sadretdinov

Keyword(s):

Survey Data ◽

Frequency Analysis ◽

Laser Doppler Flowmetry ◽

Laser Doppler ◽

Healthy Controls ◽

Doppler Flowmetry ◽

Enteroviral Infection ◽

Peripheral Microcirculation ◽

Microcirculatory Disorders

Laser Doppler flowmetry method (LDF) was used to examine children (43 patients with enteroviral infection, 34 patients with Astrakhan rickettsial fever, and 40 healthy controls). In addition, in view of LDF survey data, carried out was thermal assay and amplitude-frequency analysis of peripheral microcirculation predictors. Detected were incipient changes in microvasculature relative to microangiopathy.

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The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽

10.1024/0301-1526.34.4.243 ◽

2005 ◽

Vol 34 (4) ◽

pp. 243-249 ◽

Cited By ~ 2

Author(s):

Drinda ◽

Neumann ◽

Pöhlmann ◽

Vogelsang ◽

Stein ◽

...

Keyword(s):

Laser Doppler Flowmetry ◽

Raynaud’S Phenomenon ◽

Raynaud's Phenomenon ◽

Plasma Viscosity ◽

Laser Doppler ◽

Erythrocyte Aggregation ◽

Control Group ◽

Long Term Effects ◽

Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

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