Dynamics Of Vasomotor Thermoregdation Of The Skin: Non-invasive Assessment Of The Variability Of Laser Doppler Flowmetry

1992 ◽  
Author(s):  
Valimaki ◽  
Jahnukainen ◽  
Kerilahti ◽  
van Ravenswaaij-Arts ◽  
Jalonen
Keyword(s):  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Non Invasive

Evaluation of angiogenesis in chronic inflammation by laser-Doppler flowmetry

1988 ◽  
Vol 74 (2) ◽  
pp. 119-121 ◽  
Author(s):  
C. Orlandi ◽  
C. J. Dunn ◽  
L. G. Cutshaw
Keyword(s):  
Blood Flow ◽  
Chronic Inflammation ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Angiogenic Response ◽  
Non Invasive ◽  
Granulomatous Lesions ◽  
Invasive Method ◽  
Control Skin

1. A non-invasive method is described for the assessment of angiogenesis in chronic inflammation using laser-Doppler flowmetry. 2. Significant increases in capillary blood flow were seen on days 5 and 7 after induction of subcutaneous granulomatous lesions, as compared with control skin. 3. Changes in blood flow were accompanied by changes in pulsatile flow pattern and by an intense angiogenic response observed by light microscopy. 4. The potential application of laser-Doppler flowmetry to quantitative and qualitative studies of evolving angiogenesis in pathological responses is discussed.

NON-INVASIVE METHODS FOR STUDYING AGE-RELATED SKIN CHANGES IN VARIOUS MORPHOTYPES OF AGING

2021 ◽  
pp. 558-565
Author(s):  
Н.П. Теплюк ◽  
С.В. Лебедева
Keyword(s):  
Laser Doppler Flowmetry ◽  
Ultrasound Examination ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Skin Changes ◽  
Non Invasive ◽  
Age Related ◽  
The Face ◽  
Type 3

Цель работы - оценка изменений функционального состояния микроциркуляторного русла, изучение особенностей морфологических параметров кожи неинвазивными методами исследования при различных морфотипах старения. В исследовании приняли участие 55 человек 35-65 лет с инволюционными изменениями нижней трети лица. Выделены четыре морфотипа старения, в зависимости от которых пациенты были разделены на группы: 1-я - 19 пациенток с деформационным типом; 2-я - 17 пациенток с усталым; 3-я - 8 пациенток с мелкоморщинистым; 4-я - 11 пациенток со смешанным морфотипом. Для изучения состояния кожи использовали лазерную допплеровскую флоуметрию и УЗИ кожи (22 Mhz). Методом лазерной допплеровской флоуметрии выявлены достоверные изменения при сравнении показателей микроциркуляции и ультразвуковым методом исследования кожи - деформационного и мелкоморщинистого типов (p<0,05). У деформационного и смешанного типов наблюдали преимущественно атонический тип микроциркуляции (9,42±3,71 и 9,56±2,31 перф. ед. соответственно), а при мелкоморщинистом - спастический тип (7,86±1,6 перф. ед.), при усталом морфотипе показатель микроциркуляции был в пределах нормы (7,86±1,6 перф. ед.). Данные УЗИ кожи позволили выявить у пациенток с деформационным морфотипом старения наиболее высокие значения толщины эпидермиса (125,94±27,84 мкм), дермы (1 439±118,11 мкм), плотности дермы (12±2,59 у. е.) по сравнению с толщиной эпидермиса (85±22,01 мкм), толщиной дермы (1 130±68,55 мкм) и плотностью дермы (7,87±2,1 у. е.) при мелкоморщинистом морфотипе старения. The purpose of the work is to assess changes in the functional state of the microvasculature, study of the features of the morphological parameters of the skin by non-invasive research methods for various morphotypes of aging. The study involved 55 patients with involutional changes in the lower third of the face aged 35 to 65 years, included according with the inclusion and exclusion criteria. 4 morphotypes of aging were identified, depending on which patients were divided into corresponding groups: 1 - 19 patients with deformational type, 2 - 17 with tired type, 3 - 8 with fine wrinkled type, 4 - 11 with mixed morphotype of aging. To study the condition of the patients’ skin, laser Doppler flowmetry and ultrasound examination of the skin (22 Mhz) were used. The method of laser Doppler flowmetry revealed significant changes when comparing microcirculation indices and the ultrasound method for examining deformational and fine wrinkled type (p<0,05). In the deformational type and mixed type, a predominantly atonic type of microcirculation was observed (9,42±3,71 and 9,56±2,31 perf. u., respectively), and in fine wrinkled spastic type of microcirculation (7,86±1,6 perf. u.), in the oral morphotype the microcirculation index was within the normal range of 7,86±1,6 perf. u. The data of ultrasound examination of the skin made it possible to reveal in the deformational morphotype of aging high values of the thickness of the epidermis (125,94±27,84 μm), the dermis (1 439±118,11 μm) and the density of the dermis (12±2,59 a. u.) compared with the thickness of the epidermis 85±22,01 μm, the thickness of the dermis (1 130±68,55 μm) and the density of the dermis (7,87±2,1 c. u.) in the fine wrinkled morphotype of aging.

scholarly journals Wearable Laser Doppler Flowmetry Sensor: A Feasibility Study with Smoker and Non-Smoker Volunteers

Biosensors ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 201
Author(s):  
Mou Saha ◽  
Viktor Dremin ◽  
Ilya Rafailov ◽  
Andrey Dunaev ◽  
Sergei Sokolovski ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Blood Circulation ◽  
Blood Perfusion ◽  
Pulse Frequency ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Left Hand ◽  
Non Invasive ◽  
Blood Microcirculation ◽  
Left Middle

Novel, non-invasive wearable laser Doppler flowmetry (LDF) devices measure real-time blood circulation of the left middle fingertip and the topside of the wrist of the left hand. The LDF signals are simultaneously recorded for fingertip and wrist. The amplitude of blood flow signals and wavelet analysis of the signal are used for the analysis of blood perfusion parameters. The aim of this pilot study is to validate the accuracy of blood circulation measurements recorded by one such non-invasive wearable LDF device for healthy young non-smokers and smokers. This study reveals a higher level of blood perfusion in the non-smoker group compared to the smoker group and vice-versa for the variation of pulse frequency. This result can be useful to assess the sensitivity of the wearable LDF sensor in determining the effect of nicotine for smokers as compared to non-smokers and also the blood microcirculation in smokers with different pathologies.

scholarly journals Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice

2016 ◽  
Vol 37 (5) ◽  
pp. 1641-1655 ◽  
Author(s):  
Thijs Houben ◽  
Inge CM Loonen ◽  
Serapio M Baca ◽  
Maarten Schenke ◽  
Johanna H Meijer ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Intrinsic Signal ◽  
Non Invasive ◽  
Optical Intrinsic Signal ◽  
Dc Potential ◽  
Freely Behaving

Cortical spreading depression, which plays an important role in multiple neurological disorders, has been studied primarily with experimental models that use highly invasive methods. We developed a relatively non-invasive optogenetic model to induce cortical spreading depression by transcranial stimulation of channelrhodopsin-2 ion channels expressed in cortical layer 5 neurons. Light-evoked cortical spreading depression in anesthetized and freely behaving mice was studied with intracortical DC-potentials, multi-unit activity and/or non-invasive laser Doppler flowmetry, and optical intrinsic signal imaging. In anesthetized mice, cortical spreading depression induction thresholds and propagation rates were similar for invasive (DC-potential) and non-invasive (laser Doppler flowmetry) recording paradigms. Cortical spreading depression-related vascular and parenchymal optical intrinsic signal changes were similar to those evoked with KCl. In freely behaving mice, DC-potential and multi-unit activity recordings combined with laser Doppler flowmetry revealed cortical spreading depression characteristics comparable to those under anesthesia, except for a shorter cortical spreading depression duration. Cortical spreading depression resulted in a short increase followed by prolonged reduction of spontaneous active behavior. Motor function, as assessed by wire grip tests, was transiently and unilaterally suppressed following a cortical spreading depression. Optogenetic cortical spreading depression induction has significant advantages over current models in that multiple cortical spreading depression events can be elicited in a non-invasive and cell type-selective fashion.

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