METHOD FOR ANALYSIS OF THE DOPPLER-BROADENED SPECTRA OF LASER RADIATION FOR THE ASSESSMENT OF BLOOD MICROCIRCULATION DISTURBANCES IN DIABETES MELLITUS TYPE 2

2020 ◽  
Vol 4 (1) ◽  
pp. 80-87
Author(s):  
I.O. KOZLOV
Keyword(s):  
Diabetes Mellitus ◽  
Laser Radiation ◽  
Laser Doppler Flowmetry ◽  
Diabetes Mellitus Type 2 ◽  
Feature Space ◽  
Diabetes Mellitus Type ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
New Feature

The article is devoted to the development of laser Doppler flowmetry and analysis of the recorded signal to study the distribution of perfusion over the frequencies of Doppler broadening of laser radiation. The processing algorithm and the necessary technical conditions for the correct registration of the signal are shown. As examples of the proposed method implementation, the data are obtained from a healthy volunteer and a patient with diabetes mellitus type 2 and analyzed. According to the proposed method, processing of recorded data provides a new feature space for data analysis of laser Doppler flowmetry signal.

scholarly journals Myogenic vasomotions in postmenopausal women with normoglycemia, prediabetes and diabetes mellitus type 2

2016 ◽  
Vol 15 (3) ◽  
pp. 36-43
Author(s):  
I. S. Iskhakova ◽  
L. A. Ruyatkina ◽  
K. Y. Nikolaev ◽  
D. S. Ruyatkin
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Carbohydrate Metabolism ◽  
Postmenopausal Women ◽  
Diabetes Mellitus Type 2 ◽  
Statistical Significance ◽  
Diabetes Mellitus Type ◽  
Doppler Flowmetry ◽  
Group 1

The aim of the study. Estimate microcirculatory parameters of myogenic range in postmenopausal women with normoglycemia, prediabetes and diabetes mellitus type 2. Material and methods. Among the surveyed 94 women (58.0 (53.0; 63.0) years old), in the natural menopause (duration 7.0 (2.0; 13.0) years), depending on the status of carbohydrate metabolism (WHO, 2011) by measuring the levels of glycated hemoglobin, we identified three groups: group 1 (n = 52) - with diabetes mellitus 2 type, 2 (n = 16) - with prediabetes, 3 (n = 26) - with normoglycaemia. We evaluated anthropometric and biochemical parameters; microcirculation was assessed by laser Doppler flowmetry. Statistical analysis was performed using the SPSS software (version 17.0). The level of statistical significance of differences was at p ≤ 0.05. Results. Women with impaired glucose metabolism (group 1 and 2) with increased abdominal fat deposition have the elevated basal vasospasm and impaired microvascular reactivity due to increased myogenic tone. We found that group 1 has negative association of LDF parameters of myogenic range with blood pressure and duration of hypertension. We identified that increasing concentrations of atherogenic lipids contribute to basal and postocclusive vasodilation independently of the state of glucose metabolism. Conclusion. Identified associations and differences in the LDF parameters of myogenic range at the basal and reperfusion microcirculation reflect the increase of vasospasm and microcirculatory disturbances during progression of carbohydrate metabolism disorders in postmenopausal women.

scholarly journals Non-invasive assessment of microcirculation in patients with late-stage complications of diabetes mellitus type 2

2015 ◽  
Vol 14 (4) ◽  
pp. 28-33
Author(s):  
P. V. Vasiliev ◽  
A. N. Shishkin ◽  
N. P. Erofeev ◽  
N. A. Bubnova ◽  
I. Y. Pchelin
Keyword(s):  
Diabetes Mellitus ◽  
High Frequency ◽  
Diabetes Mellitus Type 2 ◽  
Main Group ◽  
Diabetes Mellitus Type ◽  
Diabetic Microangiopathy ◽  
Venous Stasis ◽  
Doppler Flowmetry ◽  
Complications Of Diabetes

The aim of our study was to assess of microcirculation using laser Doppler flowmetry (LDF) in patients with diabetic foot syndrome (DFS) caused by diabetes mellitus type 2. Materials and methods. The main group consisted of 16 patients with DFS. In the control group, 19 patients without diabetes mellitus were included. An LDF investigation was performed using Biopac LDF 100C system. Estimated glomerular filtration rate (eGFR) was determined using CKD-EPI formula. Results and discussion. According to LDF, patients with DFS had the severe form of microcirculatory failure, with abrupt worsening of venous drainage, caused by venous lesion during the diabetic microangiopathy. The marker LDF phenomena were decreasing of flaxmotion index, low- and high-frequency flaxmotions contribution and increasing of high-frequency flaxmotion contribution. During the eGFR decreasing in the main group a simultaneous decreasing of low-frequency flaxmotion contribution and flaxmotion index, also with increasing of high-frequency flaxmotions contribution and intravascular resistance shows to stazic form of microcirculatory disorder. Exposed correlations of LDF-indexes with eGFR can show that LDF has potential possibilities for diagnostics and progression assessment of microangiopathic changes. Summary. In patients with diabetes mellitus type 2, a progressive microcirculation failure takes place. With the development of the microangiopathy, a negative influence of venous stasis prevails over the ischemic events. The development of chronic kidney disease is an independent risk-factor of microangiopathic complications of diabetes mellitus type 2. Preclinical diagnostics of renal lesion is important for timely beginning of the protective therapy of severe microvascular complications.

Bone quality in diabetes mellitus type 2

2014 ◽  
Author(s):  
Peter Jackuliak ◽  
Zdenko Killinger ◽  
Juraj Payer
Keyword(s):  
Diabetes Mellitus ◽  
Bone Quality ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type
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