THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM

Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controlled release systems has been a challenge to formulation scientists due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. There are several advantages of matrix devices including improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilization of the drug, increased safety margin of a potent drug. This review aims on the discussion of different materials used to prepare matrix tablets, different types of matrix tablets and the drug release mechanism from the matrices.

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Effects of release modifier on Carvedilol release from Kollidon SR based matrix

International Current Pharmaceutical Journal ◽

10.3329/icpj.v1i8.11095 ◽

2012 ◽

Vol 1 (8) ◽

pp. 186 ◽

Cited By ~ 1

Author(s):

Urmi Das ◽

Mohammad Salim Hossain

Keyword(s):

Drug Release ◽

Sustained Release ◽

Microcrystalline Cellulose ◽

Matrix Tablets ◽

Dissolution Time ◽

Release Mechanism ◽

Matrix Tablet ◽

Weight Variation ◽

The Matrix ◽

Tablet Formulations

Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a> International Current Pharmaceutical Journal 2012, 1(8): 186-192

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DESIGN AND CHARACTERIZATION OF ALFUZOSIN HCL GASTRORETENTIVE FLOATING MATRIX TABLETS EMPLOYING HPMC K 100M

INDIAN DRUGS ◽

10.53879/id.55.11.10741 ◽

2018 ◽

Vol 55 (11) ◽

pp. 71-73

Author(s):

Ch. Taraka Ramarao ◽

◽

J Vijaya Ratna ◽

R. B. Srinivasa

Keyword(s):

Drug Release ◽

Dosage Forms ◽

Matrix Tablets ◽

Fickian Diffusion ◽

Release Mechanism ◽

Gastric Residence Time ◽

Drug Release Mechanism ◽

The Matrix ◽

Gastro Retentive

The present investigation involves developing gastro retentive drug delivery systems (GFDDS) of alfuzosin HCl using HPMCK100M a is the matrixing agent and floating enhancer. Sodium bicarbonate in the acidic environment reacts with the acid and produces carbon dioxide. The gastro retentive tablets can be formulated to increase the gastric residence time and thereby increase the oral bioavailability. From the drug release study, it was concluded that the AFTB4 formula of HPMC K 100 M matrix tablets gives the controlled release up to 12 hours by showing increased release with floating lag time 24 seconds. Non – Fickian diffusion was the drug release mechanism from the matrix tablets formulated employing HPMC K 100 M. The matrix tablets (AFTB4) formulated employing 40 % HPMC K 100 M are best suited to be used for gastro retentive dosage form of alfuzosin HCl. Finally, it can be concluded that good candidates for the preparation of gastro retentive dosage forms due its gastric stability, gastric absorption and better bioavailability.

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Formulation and In vitro Release Behavior of Hydroxypropyl Methylcellulose (HPMC) Matrix Tablet Containing Poorly Soluble Fenofibrate

Bangladesh Pharmaceutical Journal ◽

10.3329/bpj.v23i1.45314 ◽

2020 ◽

Vol 23 (1) ◽

pp. 10-16

Author(s):

Ramesh Kandel ◽

Tushar Saha ◽

Zia Uddin Masum ◽

Jakir Ahmed Chowdhury

Keyword(s):

Hydroxypropyl Methylcellulose ◽

In Vitro Release ◽

Pharmaceutical Journal ◽

Matrix Tablets ◽

In Vitro Dissolution ◽

Release Mechanism ◽

Matrix Tablet ◽

Dissolution Profile ◽

The Matrix

Fenofibrate, a water insoluble drug was used to prepare matrix tablet with four different viscosity grades of Hydroxypropyl Methylcellulose (HPMC) which were Methocel K4M CR, Methocel K15M CR, Methocel K100M CR and Methocel K100LV CR. The concentration of those excipients was 5, 10, 20, and 40% (w/w), respectively. The content of drug in a fixed quantity of powder in every formulation was ranged between 96.47 to 104.78 %. The dissolution study was done by using USP dissolution apparatus II. The kinetics of release was analyzed by using zero-order, first order, Korsmeyer-Peppas, Higuchi and Hixon-crowell equations to explain the drug release mechanism from the matrix tablets. In-vitro dissolution profile of matrix tablets were dependent upon the HPMC concentration and dissolution was rapid for tablets containing lower polymer proportion i.e. 5,10, and 20% Percentage (w/w) HPMC than those containing 40% (w/w) HPMC. Bangladesh Pharmaceutical Journal 23(1): 10-16, 2020

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DEVELOPMENT AND CHARACTERIZATION OF CONTROLLED RELEASE FAMOTIDINE MATRIX TABLETS CONTAINING COMPLEXES

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2017v9i4.18859 ◽

2017 ◽

Vol 9 (4) ◽

pp. 38

Author(s):

Shabnam Ain ◽

Babita Kumar ◽

Kamla Pathak

Keyword(s):

Controlled Release ◽

Polymer Blend ◽

Release Kinetics ◽

Methyl Cellulose ◽

Zero Order ◽

Matrix Tablets ◽

Release Mechanism ◽

Matrix Tablet ◽

Cyclodextrin Complex ◽

Controlled Release Tablets

Objective: The aim of the present study was to formulate the controlled release (CR) tablets of famotidine-cyclodextrin complexes to make the feasibility of complex in CR tablets and to access the kinetic of drug release mechanismMethods: In this work the solubility study of famotidine was performed in various solvents like 0.1 N HCl, phosphate buffer pH 7.4 and distilled water. Enhancement of the solubility and dissolution rate of famotidine was done by complexation with cyclodextrin before formulation into controlled release tablets. Tablets were prepared in different batches by using different concentration of HPMC K15M (hydroxy propyl methyl cellulose) and EC (ethyl cellulose) polymers and polymer blend. All batches were evaluated for pre-compression and post-compression parameters. Release kinetics was analyzed using zero order, first order, higuchi, peppas and hixon-crowell model.Results: All the formulation showed compliance with Pharmacopoeial standards. Release studies indicated that polymer blend (62%HPMCK15M and 38%EC) based matrix tablets with complexed drug was able to control the release of famotidine up to 12 h. Optimized formulation F13 containing complexed drug with same polymer blend showed zero order release and the release mechanism was predominant matrix swelling with erosion.Conclusion: Results of the present study demonstrated that the drug: β-cyclodextrin complex would be a suitable candidate for preparing controlled release tablets of famotidine to improve drug solubility, flow properties and compressibility. Thus the complex used in matrix tablet is a promising approach to achieve appropriate controlled release dosage.

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FORMULATION AND IN VITRO EVALUATION OF MATRIX TABLETS OF METOCLOPRAMIDE HYDROCHLORIDE

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i2.30506 ◽

2019 ◽

pp. 25-30

Author(s):

S. JAYA ◽

DIVYA S.

Keyword(s):

Drug Release ◽

Ethyl Cellulose ◽

Xanthan Gum ◽

Matrix Tablets ◽

Release Mechanism ◽

Content Uniformity ◽

Matrix Tablet ◽

The Matrix ◽

Metoclopramide Hydrochloride

Objective: The purpose of present study was to formulate oral sustained release matrix tablet of metoclopramide hydrochloride and to evaluate the effect of varying concentrations of hydrophobic and hydrophilic polymers on drug release. Methods: Drug–excipients compatibility studies were carried out by using Fourier transform infrared spectroscopy (FTIR). The matrix tablets were prepared by direct compression technique using Xanthan gum and ethyl cellulose alone and in combination as release retardant. Dicalcium phosphate was used as diluent. The prepared matrix tablets were evaluated for their physicochemical parameters such as weight variation, hardness, friability, content uniformity and in vitro drug release studies were performed using USP-type II (paddle) dissolution apparatus. Results: Pre and post compression parameters were evaluated and all the parameters were found within the limit. The matrix tablets prepared with xanthan gum and combination of xanthan gum and ethyl cellulose were retarded the drug release upto 12 h. Ethyl cellulose alone could not control the drug release for 12 h. The Formulation with drug to xanthan gum (1:1.5), released 97.62 % of drug in 12 h. The kinetic treatment showed that the release of drug follows zero order kinetics (R 2=0.985). Korsmeyer and Peppas equation values of n were found to be in the range of 0.40-0.56, indicating that the drug release mechanism was diffusion. Conclusion: Matrix tablet is the simple, efficient and economic method to sustain the release of metoclopramide to prevent extrapyramidal side effects.

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Effect of Channeling Agents on Release Kinetics of Stavudine from Methocel K100 LVCR and Ethocel 20 cps Based Matrix Tablets

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v14i1.23741 ◽

2015 ◽

Vol 14 (1) ◽

pp. 91-101

Author(s):

Nazia Tajrin ◽

Md Elias Al Mamun ◽

Md Habibur Rahman ◽

Md Selim Reza

Keyword(s):

Drug Release ◽

Release Kinetics ◽

Dissolution Kinetics ◽

Immune Deficiency Syndrome ◽

Matrix Tablets ◽

Drug Dissolution ◽

Release Mechanism ◽

Matrix Tablet ◽

Peg 6000 ◽

The Matrix

The study was performed to investigate the effect of channeling agent on the release profile of Stavudine from Methocel K100 LVCR and Ethocel 20 cps based matrix systems. Stavudine, a nucleoside analog drug, is used in the treatment of acquired immune deficiency syndrome (AIDS). Stavudine matrix tablet was prepared using Methocel K100 LVCR and Ethocel 20 cps as polymer and also using PEG 3350 and PEG 6000 as channeling agents. The drug release mechanisms from different matrix tablets were explored and explained by zero order, first order, Higuchi, Korsmeyer and Hixson-Crowell equations. The release rate, extent and mechanisms were found to be governed by polymer type used and the content of the channeling agent. It was found that the release of drug from the matrix tablet was increased with the increasing concentration of channeling agent. However, PEG 6000 enhanced the release of drug greater than PEG 3350 from the matrix. On the other hand, Stavudine matrix containing Ethocel 20 cps showed a strong tendency to retard the drug release to 51-56% after 8 hours of dissolution, whereas the release was found to be increased for the Methocel containing matrix to 90-100%. Kinetic modeling of dissolution profiles revealed drug release mechanism ranged from diffusion controlled or Fickian transport to anomalous type or non- Fickian transport, which was mainly dependent on the presence of relative amount of channeling agent and type of polymer. These studies indicate that the proper balance between a matrix forming agent and a channeling agent can produce optimum drug dissolution kinetics from Stavudine matrix tablet. The mechanism was also revealed by Scanning Electron Microscope (SEM) pictures taken at various intervals of dissolution which showed that the extent of pore formation in the matrix increases with the increasing amount of channeling agent and also the hydrophilic nature of the polymer used in the formulation.Dhaka Univ. J. Pharm. Sci. 14(1): 91-101, 2015 (June)

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Effects of release modifier on Carvedilol release from Kollidon SR based matrix

International Current Pharmaceutical Journal ◽

10.3329/icpj.v1i8.11248 ◽

2012 ◽

Vol 1 (8) ◽

pp. 186-192 ◽

Cited By ~ 1

Author(s):

Urmi Das ◽

Mohammad Salim Hossain

Keyword(s):

Drug Release ◽

Sustained Release ◽

Microcrystalline Cellulose ◽

Matrix Tablets ◽

Dissolution Time ◽

Release Mechanism ◽

Matrix Tablet ◽

Weight Variation ◽

The Matrix ◽

Tablet Formulations

Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.DOI: http://dx.doi.org/10.3329/icpj.v1i8.11248 International Current Pharmaceutical Journal 2012, 1(8): 186-192

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Formulation and Evaluation of Galantamine Hydrobromide Floating Matrix Tablet

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v8i2.13868 ◽

2018 ◽

Vol 8 (2) ◽

Author(s):

Poreddy Srikanth Reddy ◽

Penjuri Subhash Chandra Bose ◽

Vuppula Sruthi ◽

Damineni Saritha

Keyword(s):

Sodium Alginate ◽

Xanthan Gum ◽

Lag Time ◽

Matrix Tablets ◽

In Vitro Dissolution ◽

Matrix Tablet ◽

Compression Technique ◽

Weight Variation ◽

The Matrix

The aim of the present work was to prepare floating tablets of galantamine HBr using sodium alginate and xanthan gum as matrix forming carriers. Galantamine HBr is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. The matrix tablet formulations were prepared by varying the concentrations of sodium alginate and xanthan gum. The tablets were prepared by direct compression technique using PVP K-30 as a binder and sodium bicarbonate for development of CO2. The prepared matrix tablets were evaluated for properties such as hardness, thickness, friability, weight variation, floating lag time, compatibility using DSC and FTIR. In vitro dissolution was carried out for 12 hrs in 0.1N HCl at 37±0.5 ºC using USP paddle type dissolution apparatus. It was noted that, all the prepared formulations had desired floating lag time and constantly floated on dissolution medium by maintaining the matrix integrity. The drug release from prepared tablets was found to vary with varying concentration of the polymers, sodium alginate and xanthan gum. From the study it was concluded that floating drug delivery system for galantamine HBr can be prepared by using sodium alginate and xanthan gum as a carrier.

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Colon targeting oral matrix tablets of mesalamine: Design, development and invitro evaluation

International Journal of Novel Trends in Pharmaceutical Sciences ◽

10.26452/ijntps.v10i1.1144 ◽

2020 ◽

Vol 10 (1) ◽

pp. 18-27

Author(s):

Audinarayana N ◽

Anala Srinivasulu ◽

Vellore Sruthikumari ◽

Likitha ◽

Ananda Deepak V

Keyword(s):

Drug Release ◽

Guar Gum ◽

Stability Study ◽

Matrix Tablets ◽

Drug Dissolution ◽

Matrix Tablet ◽

Cellulose Acetate Phthalate ◽

Design Development ◽

Release Pattern ◽

The Matrix

The principle in this present research is to formulate Mesalamine containing colon targeted tablets by using different polymers and evaluate the effect of different polymers in drug release pattern. The matrix tablets of Mesalamine are formulated by polysaccharides based polymers like Cellulose acetate phthalate (CAP), Ethyl cellulose (EC), Guar gum (GG) and Xanthan gum (XG) which protects the drug to release in Stomach and Small Intestine. The invitro drug dissolution investigation of F2 (GG and XG) Matrix tablet was controlled by swelling into a viscous gel in colonic pH, which have been accomplished as the best tablet. The optimized tablet F2 was found to be stable in stability study (short term) with reproducible evaluation data, which also shows the highest swelling index, increased viscosity in colonic pH. The drug release pattern from the F2 formulation follows swelling and erosion behavior. From the data it show that F2 tablets suitable for providing colon targeted drug delivery.

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Optimizing the Role of Polymer Blend in the Preparation of Acyclovir Controlled-Release Tablets: An Approach for Better Patient Compliance

10.20944/preprints201807.0165.v1 ◽

2018 ◽

Author(s):

Barkat Khan ◽

Faheem Haider ◽

Kifayat Shah ◽

Bushra Uzair ◽

Kaijian Hou ◽

...

Keyword(s):

Controlled Release ◽

Drug Release ◽

Release Kinetics ◽

Immediate Release ◽

Matrix Tablets ◽

Release Mechanism ◽

In Vitro Drug Release ◽

Solubility Study ◽

Release Data

This study was carried out to formulate and evaluate controlled release (CR) matrix tablets of Acyclovir using combination of hydrophilic and hydrophobic polymers. Acyclovir is a guanine derivative and is its half-life is short hence administered five times a day using immediate release tablets. Six formulations (F1-F6) were developed using Ethocel and Carbopol in equal combinations at drug-polymer (D:P) ratio of 10:5, 10:6, 10:7, 10:8, 10:9 and 10:10. Solubility study was performed using six different solvents. The compatibility studies were carried out using FTIR and DSC. According to USP, Quality Control and dimensional tests (hardness, friability, disintegration and thickness) were executed. In-vitro drug release studies of Acyclovir was carried out in dissolution apparatus using using 0.1 N HCl medium at constant temperature of 37 ± 0.5 ºC. In order to analyze the drug release kinetics, five different mathematical models were applied to the release data. The results showed that there was no incompatibility between drug and polymers. Physical QC tests were found within limits of USP. The release was retarded upto 24 hrs and non-fickian in-vitro drug release mechanism was found. A formulation developed using blend of polymers, showed excellent retention and desired release profiles thus providing absolute control for 24 hrs.

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