scholarly journals NEUROCHEMICAL ASSESSMENT AND BEHAVIORAL ROLE OF TUBEROINFUNDIBULAR PEPTIDE-39 IN ACUTE RESTRAINT STRESS-INDUCED DEPRESSION IN RATS.

2018 ◽  
Vol 11 (1) ◽  
pp. 332
Author(s):  
Sankar V ◽  
Ramanathan M ◽  
Venkatesh G
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Gamma Aminobutyric Acid ◽  
Ambulatory Activity ◽  
Acute Restraint Stress ◽  
Behavioral Parameters ◽  
Potent Agonist ◽  
Tuberoinfundibular Peptide ◽  
Immobility Period

 Objective: Tuberoinfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model.Methods: Rats were exposed to ARS for 2 h to establish the depression and then subjected to open field and forced swim test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as reference standard.Results: The results depict ARS significantly diminished the TIP39 expression in cerebral regions and causes depression-like behavior. TIP39 significantly decreased the immobility period in FST. In the OFT, TIP39 significantly increased the ambulatory activity and did not alter the rearing and grooming activity in comparison to ARS group. After TIP39 treatment, plasma noradrenaline levels were significantly increased, whereas the serotonin levels were unaltered. The corticosterone levels also decreased significantly. In rat brain tissues, TIP39 significantly reversed the abnormalities in glutamate and gamma-aminobutyric acid (GABA) level by ARS induction. In contrast, HYWH-treated rats did not show any significant variations in the neurochemical and behavioral parameters in comparison to ARS rats.Conclusion: Our reports submitted that the primary evidence depicting the stimulation of TIP39 expression could modulate the monoaminergic, GABAergic, and glutaminergic release with the support of hypothalamic-pituitary-adrenal axis that can be produced an antidepressant-like effect evident with the interactive study.

scholarly journals NEUROCHEMICAL ASSESSMENT AND BEHAVIORAL ROLE OF TUBEROINFUNDIBULAR PEPTIDE-39 IN ACUTE RESTRAINT STRESS-INDUCED DEPRESSION IN RATS.

2018 ◽  
Vol 11 (1) ◽  
pp. 332
Author(s):  
Sankar V ◽  
Ramanathan M ◽  
Venkatesh G
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Gamma Aminobutyric Acid ◽  
Ambulatory Activity ◽  
Acute Restraint Stress ◽  
Behavioral Parameters ◽  
Potent Agonist ◽  
Tuberoinfundibular Peptide ◽  
Immobility Period

 Objective: Tuberoinfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model.Methods: Rats were exposed to ARS for 2 h to establish the depression and then subjected to open field and forced swim test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as reference standard.Results: The results depict ARS significantly diminished the TIP39 expression in cerebral regions and causes depression-like behavior. TIP39 significantly decreased the immobility period in FST. In the OFT, TIP39 significantly increased the ambulatory activity and did not alter the rearing and grooming activity in comparison to ARS group. After TIP39 treatment, plasma noradrenaline levels were significantly increased, whereas the serotonin levels were unaltered. The corticosterone levels also decreased significantly. In rat brain tissues, TIP39 significantly reversed the abnormalities in glutamate and gamma-aminobutyric acid (GABA) level by ARS induction. In contrast, HYWH-treated rats did not show any significant variations in the neurochemical and behavioral parameters in comparison to ARS rats.Conclusion: Our reports submitted that the primary evidence depicting the stimulation of TIP39 expression could modulate the monoaminergic, GABAergic, and glutaminergic release with the support of hypothalamic-pituitary-adrenal axis that can be produced an antidepressant-like effect evident with the interactive study.

scholarly journals Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats

2017 ◽  
Vol 175 ◽  
pp. 16-21 ◽  
Author(s):  
Josiane O. Duarte ◽  
Karina S. Gomes ◽  
Ricardo L. Nunes-de-Souza ◽  
Carlos C. Crestani
Keyword(s):  
Restraint Stress ◽  
Preoptic Area ◽  
Acute Restraint Stress ◽  
Neuroendocrine Responses

scholarly journals EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA ROOT L. ON ACUTE RESTRAINT STRESS-INDUCED ANXIETY AND DEPRESSION IN SWISS ALBINO MICE

2018 ◽  
Vol 11 (10) ◽  
pp. 182 ◽  
Author(s):  
Shashikumara Shashikumara ◽  
Prathima C ◽  
Amrutheswari B
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Phytochemical Analysis ◽  
Mimosa Pudica ◽  
Swiss Albino Mice ◽  
Acute Restraint Stress ◽  
Immobility Time ◽  
Albino Mice

Objective: The present study is undertaken to study the ameliorative effects of ethanolic extract of Mimosa pudica root (EMPR) on stress-induced anxiety and depressive-like behavior in Swiss albino mice.Methods: The animals were subjected to acute restraint stress (ARS) for 7 days, and on the 8th day after drugs administration, the antianxiety effect was evaluated using elevated plus maze (EPM) test. Antidepressant activity was evaluated by animal despair models-forced swim test and tail suspension test. Phytochemical analysis of the extract was also conducted.Results: EMPR (1000 and 2000 mg/kg) and the combined test groups have shown significant antianxiety effects similar to the standard diazepam as indicated by an improved open arm exploratory behavior in EPM model. EMPR also significantly reduced the immobility time in the animal despair models tested.Conclusion: Results suggest that EMPR possesses significant anxiolytic and antidepressant activity in male Swiss albino mice.

Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats

Stress ◽  
2009 ◽  
Vol 12 (3) ◽  
pp. 268-278 ◽  
Author(s):  
C. C. Crestani ◽  
F. H. F. Alves ◽  
R. F. Tavares ◽  
F. M. A. Corrêa
Keyword(s):  
Restraint Stress ◽  
Cardiovascular Responses ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Acute Restraint Stress

scholarly journals Efficacy of Ocimum sanctum for Relieving Stress: A Preclinical Study

2012 ◽  
Vol 13 (6) ◽  
pp. 782-786 ◽  
Author(s):  
SM Manjunath ◽  
Lakshmana Rao Bathala ◽  
Ch Vekateswara Rao ◽  
S Vinuta ◽  
Raghu Vemulapalli
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Preclinical Study ◽  
Anxiety And Depression ◽  
Ocimum Sanctum ◽  
Albino Rats ◽  
Rotarod Test ◽  
Swim Test ◽  
Anxiolytic Agent ◽  
Immobility Period

ABSTRACT History and objective The aim of this study was to study the anxiolytic effects of Ocimum sanctum stress-induced anxiety. Materials and methods The study was carried out using male albino rats (200 ± 50 gm), male albino mice (25 ± 100) the effect of O. sanctum evaluated for anxiety and depression using forced swim test FST and rotarod test. Results Restraint stress (3 hours/day for six consecutive days) induced a significant reduction. It was significantly decreases the mobility period during stress. The standard deviation values are 14.4 and 9.26 and is statistically significant (p = 0.001). In rotarod test, (a) increased latency and (b) decreased ambulation and rearing were also reversed by O. sanctum. A significant increase in immobility period was observed in FST and TST after restraint stress. O. sanctum and C. sinensis significantly reduced the immobility times of rats in FST and TST. Conclusion Ocimum sanctum possess significant antistress activity but the magnitude and efficacy for relieving stress is less, when compare to standard anxiolytic agent, i.e. Alprazolam. How to cite this article Bathala LR, Rao CV, Manjunath SM, Vinuta S, Vemulapalli R. Efficacy of Ocimum sanctum for Relieving Stress: A Preclinical Study. J Contemp Dent Pract 2012;13(6):782-786.

Acute Restraint Stress in Zebrafish: Behavioral Parameters and Purinergic Signaling

2011 ◽  
Vol 36 (10) ◽  
pp. 1876-1886 ◽  
Author(s):  
Angelo L. Piato ◽  
Denis B. Rosemberg ◽  
Katiucia M. Capiotti ◽  
Anna M. Siebel ◽  
Ana P. Herrmann ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Purinergic Signaling ◽  
Acute Restraint Stress ◽  
Behavioral Parameters

Evidence for a role of GABAA receptor in the acute restraint stress-induced enhancement of spatial memory

2007 ◽  
Vol 1181 ◽  
pp. 61-73 ◽  
Author(s):  
Gang Zheng ◽  
Xueping Zhang ◽  
Yaoming Chen ◽  
Yun Zhang ◽  
Wenjing Luo ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Gabaa Receptor ◽  
Restraint Stress ◽  
Acute Restraint Stress

scholarly journals The role of CRH in behavioral responses to acute restraint stress in zebrafish

2012 ◽  
Vol 36 (1) ◽  
pp. 176-182 ◽  
Author(s):  
Gabriele Ghisleni ◽  
Katiucia M. Capiotti ◽  
Rosane S. Da Silva ◽  
Jean P. Oses ◽  
Ângelo L. Piato ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Behavioral Responses ◽  
Acute Restraint Stress

Acute restraint stress produces behavioral despair in weanling rats in the forced swim test

2009 ◽  
Vol 82 (2) ◽  
pp. 219-222 ◽  
Author(s):  
Blandina Bernal-Morales ◽  
Carlos M. Contreras ◽  
Jonathan Cueto-Escobedo
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Behavioral Despair ◽  
Swim Test ◽  
Acute Restraint Stress ◽  
Forced Swim ◽  
Weanling Rats
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