scholarly journals OPTIMIZATION AND SOLUBILIZATION STUDY OF NANOEMULSION BUDESONIDE AND CONSTRUCTING PSEUDOTERNARY PHASE DIAGRAM

2019 ◽  
Vol 12 (1) ◽  
pp. 551
Author(s):  
Raman Kumar Puppala ◽  
Vijaya Lakshmi A
Keyword(s):  
Phase Diagram ◽  
Allergic Rhinitis ◽  
Maximum Concentration ◽  
Ternary Phase ◽  
Skin Disorders ◽  
Solubility Study ◽  
Solubility Studies ◽  
Anti Inflammatory ◽  
Pseudoternary Phase Diagram ◽  
Inflammatory Effect

Objective: The aim of the present study was to formulate and optimize budesonide nanoemulsions for targeting inflammation.Methods: Budesonide is only found in individuals that have used or taken this drug. It is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The exact mechanism of the action of budesonide in the treatment of Crohn’s disease is not fully understood. However, being a glucocorticosteroid, budesonide has a high local anti-inflammatory effect. The formulation was optimized for different components and the solubility study for the oil in surfactant and cosurfactant mix ratio was optimized using ternary phase diagram.Results: The surfactant mix ratio was optimized as 1:3 where the maximum concentration of the oil has solubilized and the nanoemulsion area was increased.Conclusion: Budesonide nanoemulsion for targeting inflammation and the pseudoternary phase diagram for the solubility studies and the components of different phases were optimized and achieved through this study.

scholarly journals OPTIMIZATION AND SOLUBILIZATION STUDY OF NANOEMULSION BUDESONIDE AND CONSTRUCTING PSEUDOTERNARY PHASE DIAGRAM

2019 ◽  
Vol 12 (1) ◽  
pp. 551
Author(s):  
Raman Kumar Puppala ◽  
Vijaya Lakshmi A
Keyword(s):  
Phase Diagram ◽  
Allergic Rhinitis ◽  
Maximum Concentration ◽  
Ternary Phase ◽  
Skin Disorders ◽  
Solubility Study ◽  
Solubility Studies ◽  
Anti Inflammatory ◽  
Pseudoternary Phase Diagram ◽  
Inflammatory Effect

Objective: The aim of the present study was to formulate and optimize budesonide nanoemulsions for targeting inflammation.Methods: Budesonide is only found in individuals that have used or taken this drug. It is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The exact mechanism of the action of budesonide in the treatment of Crohn’s disease is not fully understood. However, being a glucocorticosteroid, budesonide has a high local anti-inflammatory effect. The formulation was optimized for different components and the solubility study for the oil in surfactant and cosurfactant mix ratio was optimized using ternary phase diagram.Results: The surfactant mix ratio was optimized as 1:3 where the maximum concentration of the oil has solubilized and the nanoemulsion area was increased.Conclusion: Budesonide nanoemulsion for targeting inflammation and the pseudoternary phase diagram for the solubility studies and the components of different phases were optimized and achieved through this study.

Anti-inflammatory effect of epigallocatechin gallate in a mouse model of ovalbumin-induced allergic rhinitis

2017 ◽  
Vol 49 ◽  
pp. 102-108 ◽  
Author(s):  
Meng Fu ◽  
Shulian Fu ◽  
Saihong Ni ◽  
Liyuan Zou ◽  
Yumei Liu ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Epigallocatechin Gallate ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Decreased expression of interleukin‑37 and its anti‑inflammatory effect in allergic rhinitis

2017 ◽  
Author(s):  
Yang Shen ◽  
Xia Ke ◽  
Liu Yun ◽  
Guo‑Hua Hu ◽  
Hou‑Yong Kang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals In Vivo Anti-Inflammatory Effect of H1 Antihistamines in Allergic Rhinitis: A Randomized Clinical Trial

2015 ◽  
Vol 32 (4) ◽  
pp. 352-358 ◽  
Author(s):  
Corina I. Bocsan ◽  
Adriana I. Bujor ◽  
Nicolae Miron ◽  
Stefan C. Vesa ◽  
Diana Deleanu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Allergic Rhinitis ◽  
Randomized Clinical Trial ◽  
H1 Antihistamines ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Preparation and Characterization of Topical Letrozole Nanoemulsion for Breast Cancer

2020 ◽  
Vol 29 (1) ◽  
pp. 195-206
Author(s):  
Ihab D. Hammodi ◽  
Shaimaa N. Abd Alhammid
Keyword(s):  
Breast Cancer ◽  
Phase Diagram ◽  
Ternary Phase ◽  
Ternary Phase Diagram ◽  
Enzyme System ◽  
Tween 80 ◽  
Deionized Water ◽  
Water Based ◽  
Solubility Studies

Letrozole (LZL) is a non-steroidal competitive aromatase enzyme system inhibitor. The aim of this study is to improve the permeation of LZL through the skin by preparing as nanoemulsion using various numbers of oils, surfactants and co-surfactant with deionized water. Based on solubility studies, mixtures of oleic acid oil and tween 80/ transcutol p as surfactant/co-surfactant (Smix) in different percentages were used to prepare nanoemulsions (NS). Therefore, 9 formulae of (o/w) LZL NS were formulated, then pseudo-ternary phase diagram was used as a useful tool to evaluate the NS domain at Smix ratios: 1:1, 2:1 and 3:1.

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

2019 ◽  
pp. 1-9
Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Time Course ◽  
Acute Inflammation ◽  
Lichen Species ◽  
Paw Edema ◽  
Sod Activity ◽  
Edema Formation ◽  
Lobaria Pulmonaria ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

Anti-inflammatory effect of Curcuma longa (turmeric) rhizome when administered topically in gel form

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AH Mollik ◽  
W Mozammel Haq ◽  
S Chandra Bachar ◽  
R Jahan ◽  
M Rahmatullah
Keyword(s):  
Curcuma Longa ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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