scholarly journals SYNTHESIS, CHARACTERIZATION, IN VITRO ANTIMICROBIAL, ANTHELMINTIC AND DOCKING STUDIES OF NEW 2-[(E)-{[4-(1H-1,2,4-TRIAZOL-1 YLMETHYL)PHENYL]IMINO} METHYL]PHENOL, AND THEIR COMPLEXES WITH 3D METAL IONS

2016 ◽  
Vol 8 (9) ◽  
pp. 134
Author(s):  
Jithendra Kumara K.s. ◽  
Krishnamurthy G. ◽  
Sunil Kumar N.
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Research Work ◽  
Anthelmintic Activity ◽  
Triazole Ring ◽  
Diffusion Method

<p><strong>Objective: </strong>The main objectives of this research work is the synthesis and characterization of biologically potential triazole ring containing the Schiff base legend and their transition metal complexes, followed by screenings of their antimicrobial and anthelmintic activity the results of antimicrobial activity were compared with docking scores.</p><p><strong>Methods: </strong>The<strong> </strong>coordination complexes of Co(II), Cu(II), Fe(III) and Zn(II) with Schiff base derived ligand 4-(1<em>H</em>-1,2,4-triazol-1-ylmethyl) aniline and substituted aldehydes have been synthesized. The complexes are characterized by elemental analysis, conductivity measurements, electronic, IR, and <sup>1</sup>H NMR spectral data. The synthesized compounds were also screened <em>In vitro</em> antimicrobial activity was carried out according to diffusion method by using agar and potato dextrose agar at 100, 500 and 700 mg/ml concentrations in DMF.<strong> </strong>HEX 8.0<strong> </strong>programmers were used to perform the docking experiments on <em>nucleotide </em>of <em>S. typhi </em><em>at</em> as ligand [PDB: 3B6O].</p><p><strong>Results: </strong>Schiff base ligand and their transition metal complexes were studied for antimicrobial activity as well as docking. The results of both studies concluded that 4a, 4c and 4d compounds are more active in minimum inhibition concentration (30μg/ml) against <em>Staphylococcus aureus</em> (<em>S. aureus), Salmonella typhi (S. typlei)</em> bacteria and <em>Penicillium chrysogenum</em> (<em>P. Crysogenum) </em>fungi. The compounds showed highest docking score (-257.47,-275.61 and-280.17 respectively) with the secondary structure of the alpha-amylase with a nucleotide from <em>s. typhi</em> in the solid model. In the study of anthelmintic activity among these three compounds, 4d compound exhibits more activity compared with the standard.</p><strong>Conclusion: </strong>The compounds 4a, 4c and 4d were found to be more promising pharmacological activity this observation may promote a further development of this triazole group of compounds which may lead to better pharmacological profile than standard drugs. <p> </p>

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

scholarly journals Synthesis and Spectral Studies of 4,4′-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2- methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

2020 ◽  
Vol 32 (7) ◽  
pp. 1768-1772
Author(s):  
Anita Rani ◽  
Manoj Kumar ◽  
Hardeep Singh Tuli ◽  
Zahoor Abbas ◽  
Vinit Prakash
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Analytical Techniques ◽  
Spectral Studies

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

In Vitro Evaluation of Antifungal Activities by Permeation of Ru(III) Complexes Derived from Chitosan-Schiff Base Ligand

2020 ◽  
Vol 3 (3) ◽  
pp. 212-220
Author(s):  
T. Vadivel ◽  
M. Dhamodaran ◽  
S. Kulathooran ◽  
M. Kavitha ◽  
K. Amirthaganesan
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Diffusion Method ◽  
Bidentate Ligands ◽  
Antifungal Activities ◽  
Study Results ◽  
Chitosan Schiff Base

Background: The transition metal complexes are derived from a natural biopolymer which is a very potent material in various research areas of study. Objective: This study aims to show the preparation of ruthenium(III) complexes from chitosan Schiff base ligand for effective application in antifungal studies. Methods: Chemical modification was carried out through a condensation reaction of chitosan with some aromatic aldehydes, which resulted in the formation of a bidentate Schiff base ligand. The Ru(III) complexes were prepared by complexation of ruthenium metal ion with bidentate ligands. The series of Ru(III) complexes were characterized by Scanning Electron Microscope with Electron dispersive X-ray (SEM-EDX) analysis, Powder XRD. The biopolymer-based transition metal complexes have potential uses for their biological activities. The synthesized metal complexes were directed for antifungal study by the disc diffusion method. Results: The antifungal study results showed that the transition metal complexes have significant antifungal activities against some vital fungal pathogens such as Aspergillus flavus, Aspergillus niger, Fusarium oxysporum, Penicillim chryogenum and Trigoderma veride. Conclusion: A chitosan biopolymer offers some peculiar features such as biodegradability, biocompatibility etc., which are favorable for green synthesis of transition metal complexes through complexation with bidentate ligands. These metal complexes possess good antifungal property due to their chelation effect on micro-organisms.

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