Essential fatty acids enhance free radical generation and lipid peroxidation to induce apoptosis of tumor cells

2011 ◽  
Vol 6 (4) ◽  
pp. 463-489 ◽  
Author(s):  
Undurti N Das
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acids ◽  
Free Radical ◽  
Tumor Cells ◽  
Essential Fatty Acids ◽  
Free Radical Generation ◽  
Radical Generation

Mechanism of Antihepatotoxic Activity of Glycyrrhizin, I: Effect on Free Radical Generation and Lipid Peroxidation

Planta Medica ◽  
1984 ◽  
Vol 50 (04) ◽  
pp. 298-302 ◽  
Author(s):  
Yoshinobu Kiso ◽  
Masahiro Tohkin ◽  
Hiroshi Hikino ◽  
Masao Hattori ◽  
Tatsuya Sakamoto ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Free Radical Generation ◽  
Radical Generation ◽  
Antihepatotoxic Activity

scholarly journals Enhancement of Iron-Catalyzed Free Radical Formation by Acidosis in Brain Homogenates: Difference in Effect by Lactic Acid and CO2

1989 ◽  
Vol 9 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Stig Rehncrona ◽  
Hans Nielsen Hauge ◽  
Bo K. Siesjö
Keyword(s):  
Lipid Peroxidation ◽  
Lactic Acid ◽  
Free Radical ◽  
Lactic Acidosis ◽  
Fold Increase ◽  
Tocopherol Concentration ◽  
Bicarbonate Buffer ◽  
Free Radical Generation ◽  
Radical Generation ◽  
Brain Tissues

The influence of lactic acidosis and of extreme hypercapnia on free radical generation and lipid peroxidation in brain tissues was studied. Cortical homogenates were prepared from the rat brain in a bicarbonate buffer and incubated for 60 min. Lipid peroxidation was evaluated by measurements of thiobarbituric acid reactive (TBAR) material and α-tocopherol analysis. The pH during incubations were decreased to 6.10–6.20 by either lactic acid administration or equilibration with 60% CO2 gas in paired experiments. In homogenates treated with lactic acid there was a 20-fold increase in TBAR material and the α-tocopherol concentration decreased to ∼60% of control. There was only a 10-fold increase in TBAR material and no change in α-tocopherol concentration if acidosis was induced by CO2. These differences between lactic acidosis and hypercapnic acidosis were statistically highly significant. The results indicate that lactic acidosis has a more pronounced effect in augmenting free radical generation in brain tissues than acidosis due to an increase in CO2 tension. It is suggested that this effect of lactic acid is mediated by increased dissociation of catalytic iron from proteins of the transferrin type.

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