scholarly journals The impact of mismatch repair status to the preoperative staging of colon cancer: implications for clinical management

2020 ◽  
Vol 9 (2) ◽  
pp. CRC20
Author(s):  
Emilie Erbs ◽  
Søren Rafael Rafaelsen ◽  
Jan Lindebjerg ◽  
Lars Henrik Jensen ◽  
Torben Frøstrup Hansen
Keyword(s):  
Colon Cancer ◽  
Mismatch Repair ◽  
Preoperative Staging ◽  
Lymph Node Staging ◽  
Clinical Database ◽  
National Clinical Database ◽  
Cancer Group ◽  
Metastatic Involvement ◽  
Mismatch Repair Status ◽  
The Impact

Aims: We sought to investigate if mismatch repair (MMR) status influences the preoperative staging of local colon cancer. Methods: Data from 590 patients in the Danish Colorectal Cancer Group national clinical database who were operated on for stage I-III colon cancer in 2010-15 were included. MMR status was determined by immunohistochemistry. Results: 22.9% had deficient(d) MMR tumors. Correlation of the clinical and pathological T-category was significant for both groups. The correlation of pre- and postoperative N-category was inferior (p >0.05) in dMMR cancers compared to a significant (p <0.01) correlation in proficient MMR cancers. 64.8% of dMMR tumors assessed node-positive demonstrated no sign of metastatic involvement at the postoperative assessment. Conclusion: MMR status seems to impact the accuracy of preoperative lymph node staging.

The impact of mismatch repair status to the preoperative staging of local colon cancer: Implications for clinical management.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 16-16
Author(s):  
Torben Hansen ◽  
Emilie Erbs ◽  
Natacha D. Trabjerg ◽  
Soeren Rafael Rafaelsen ◽  
Jan Lindebjerg ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Ct Scan ◽  
Mismatch Repair ◽  
Clinical Management ◽  
Preoperative Staging ◽  
Lymph Node Staging ◽  
Cancer Group ◽  
Preoperative Ct ◽  
Pn Stage ◽  
The Impact

16 Background: Computed tomography (CT) scan is standard in preoperative local staging of colon cancer. Tumours with a deficient mismatch repair (dMMR) system are characterised by unique clinical and pathophysiologic aspects that may impact on the accuracy of the preoperative CT staging. Methods: Data from the Danish Colorectal Cancer Group national clinical database addressing a cohort of patients operated for stage I-III colon cancer in 2010-15 was analysed. The analyses of MMR status had been conducted consecutively through means of immunohistochemistry. All CT scans were blindly assessed by a certified radiologist. Results: Data from 590 patients, operated at a specialised cancer centre were available for analyses. A dMMR phenotype was detected in 135 (22.9%) of the patients. The overall correlation of the clinical and pathological T-category was significant for both groups. There was inferior correlation between cN and pN (p > 0.05) in pMMR cancers with a higher degree of over-staging assessed by CT-scan, compared to a significant correlation between cN and pN stage in pMMR cancers (p < 0.01). Of the 91 dMMR tumours judged node-positive by the preoperative CT scan, 59 (64.8%) showed no sign of metastatic involvement at the postoperative assessment. Conclusions: The accuracy of preoperative CT lymph node staging in colon cancer seems to differ depending on MMR status and may impact the clinical management including the neoadjuvant setting.

Mismatch Repair status predispose to emergency presentation in colon cancer patients.

2021 ◽  
Vol 47 (2) ◽  
pp. e4
Author(s):  
Ioannis Gkekas ◽  
Jan Novotny ◽  
Karin Strigård ◽  
Richard Palmqvist ◽  
Ulf Gunnarsson
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Mismatch Repair ◽  
Emergency Presentation ◽  
Mismatch Repair Status

Mismatch repair status predicts survival after adjuvant treatment in stage II colon cancer patients

2019 ◽  
Vol 121 (2) ◽  
pp. 392-401 ◽  
Author(s):  
I. Gkekas ◽  
J. Novotny ◽  
P. Fabian ◽  
R. Nemecek ◽  
R. Palmqvist ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Mismatch Repair ◽  
Adjuvant Treatment ◽  
Stage Ii ◽  
Mismatch Repair Status ◽  
Stage Ii Colon Cancer

scholarly journals Role of Deficient DNA Mismatch Repair Status in Patients With Stage III Colon Cancer Treated With FOLFOX Adjuvant Chemotherapy

JAMA Oncology ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 379 ◽  
Author(s):  
Aziz Zaanan ◽  
Qian Shi ◽  
Julien Taieb ◽  
Steven R. Alberts ◽  
Jeffrey P. Meyers ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Stage Iii ◽  
Dna Mismatch ◽  
Stage Iii Colon Cancer ◽  
Mismatch Repair Status

scholarly journals The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4384
Author(s):  
Malene Roland V. Pedersen ◽  
Søren Rafael Rafaelsen ◽  
Jan Lindebjerg ◽  
Torben Frøstrup Hansen ◽  
Hans Bjarke Rahr
Keyword(s):  
Colon Cancer ◽  
Bowel Resection ◽  
Preoperative Staging ◽  
Clinical Staging ◽  
Resected Specimen ◽  
Common Disease ◽  
Curative Intent ◽  
Mmr Deficiency ◽  
The Impact ◽  
Histopathological Type

Background: Colon cancer is a common disease in western populations. The aim of this study was to assess the impact of mismatch repair (MMR) deficiency and other patient and tumor characteristics on the accuracy of preoperative staging by comparing histopathological T- and N-categories of the resected specimen with the preoperative clinical stage in a nationwide cohort of patients treated for colon cancer by elective bowel resection with curative intent. Methods: A register study of a cohort extracted from the Danish Colorectal Cancer Group (DCCG) database, which holds prospective data on all new cases of colon and rectum cancer in Denmark. Patients diagnosed with colon cancer and treated with an elective bowel resection with curative intent in the years 2016–2019 were analyzed. Results: A total of 6102 patients were included (n = 3161 (52%) men and n = 2941 (48%) women) with a median age of 72 years (range 23–97 years). MMR was deficient in 24% of the patients and proficient in 76%. MMR deficiency, tumor sidedness and histopathological type were significant predictors of the accuracy of preoperative staging of colon cancer in univariate and multivariate analysis. MMR status in particular showed a strong impact on the risk of overstaging. Conclusions: MMR deficiency, but also tumor sidedness and to some degree histopathological type, impacted the accuracy of preoperative staging of colon cancer. MMR status should be taken into consideration in everyday clinical staging.

scholarly journals Clinical Implications of Mismatch Repair Status in Patients With High-risk Stage II Colon Cancer

In Vivo ◽  
2019 ◽  
Vol 33 (2) ◽  
pp. 649-657 ◽  
Author(s):  
DONG WON BAEK ◽  
BYUNG WOOG KANG ◽  
SOO JUNG LEE ◽  
HYE JIN KIM ◽  
SU YEON PARK ◽  
...  
Keyword(s):  
Colon Cancer ◽  
High Risk ◽  
Mismatch Repair ◽  
Stage Ii ◽  
Clinical Implications ◽  
Mismatch Repair Status ◽  
Stage Ii Colon Cancer
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