New developments in optical sensing technology: an interview with Adrien Desjardins

2020 ◽  
Vol 16 (2) ◽  
pp. 65-67
Author(s):  
Adrien Desjardins
Keyword(s):  
Optical Sensors ◽  
Biomedical Engineering ◽  
Massachusetts Institute Of Technology ◽  
Cardiovascular Devices ◽  
Technical Developments ◽  
Sensing Technology ◽  
Interventional Devices ◽  
Institute Of Technology ◽  
Philips Research

Adrien has a PhD from Harvard and the Massachusetts Institute of Technology (both MA, USA) in biomedical engineering and biophysics, with a specific focus on cardiovascular devices, fiber optic sensing and optical coherence tomography. After his PhD, he led technical developments in an internal venture at Philips Research (Eindhoven, Netherlands) to develop devices with integrated optical sensors and brought this technology from benchtop prototypes to in vivo human studies. In addition to his responsibilities at Echopoint Medical (London, UK) where he is Chief Technology Officer, Adrien is also is a Professor of Biomedical Engineering at University College London (London, UK), where he leads the interventional devices group with a vision to develop novel methods for performing physiological measurements and imaging with minimally invasive devices. He has over 52 patent applications and granted patents.

scholarly journals Le microbiote intestinal de souris, un enjeu majeur dans la reproductibilité des résultats des modèles in vivo

2018 ◽  
Vol 34 (6-7) ◽  
pp. 609-611
Author(s):  
Benjamin Estavoyer ◽  
Saidi Soudja
Keyword(s):  
Imperial College ◽  
Massachusetts Institute ◽  
Massachusetts Institute Of Technology ◽  
Haut Débit ◽  
Link Type ◽  
Institute Of Technology ◽  
Microbiote Intestinal

Dans le cadre d’un partenariat avec médecine/sciences, et pour la seconde année, des étudiants du module d’immunologie virologie et cancer du Master de cancérologie de Lyon présentent une analyse d’articles scientifiques récents faisant état d’observations innovantes et importantes. Ce travail a été encadré par des chercheurs confirmés du département d’immunologie, virologie et inflammation du CRCL. Le master de cancérologie de Lyon (Lyon1-VetAgroSup) accueille chaque année 30 à 40 étudiants en M1 et en M2. Ce master dit « d’excellence » assure aux étudiants de M1 une formation à la cancérologie reposant sur un socle de base commun (biologie cellulaire, moléculaire, immunologie, bio-statistique…) En M2, les étudiants peuvent choisir l’une des trois spécialités suivantes : le Master recherche « Recherche en cancérologie », le Master recherche et professionnel « Technologie haut débit en cancérologie » et enfin le Master recherche et professionnel « Innovations thérapeutiques en cancérologie ». Le Master de cancérologie de Lyon repose sur une forte implication des chercheurs et enseignants-chercheurs du laboratoire d’excellence en développement et cancérologie (LabEx DEVweCAN), ainsi que sur un partenariat solide avec plusieurs instituts dont le MIT (Massachusetts Institute of Technology, Cambridge, États-Unis), l’université d’Harvard (Boston, États-Unis), l’université Johns Hopkins (Baltimore, États-Unis), l’Imperial College of London (Royaume-Uni), les universités de Jiao Tong (République Populaire de Chine) et de Tokyo (Japon), entre autres. Pour plus d’information : http://devwecan.universite-lyon.fr/formation/

A Role for fbxo5 in Zebrafish Myelopoiesis.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3608-3608 ◽  
Author(s):  
Jennifer Rhodes ◽  
Adam Amsterdam ◽  
Karen Ho ◽  
John P. Kanki ◽  
Nancy Hopkins ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Myeloid Cell ◽  
Cell Types ◽  
Cell Development ◽  
Massachusetts Institute Of Technology ◽  
Acridine Orange Staining ◽  
Whole Mount ◽  
Institute Of Technology

Abstract The zebrafish is a powerful model system for investigating embryonic vertebrate hematopoiesis that allows for the critical in vivo analysis of cell development and lineage determination. Conservation of the variety of blood cell types and key regulatory factors between mammals and zebrafish suggests that the regulatory mechanisms directing lineage specification are similarly conserved. To identify novel genes necessary for normal myeloid cell development, we have analyzed a panel of zebrafish insertional mutants, provided by Nancy Hopkins at Massachusetts Institute of Technology (MIT), and identified mutants with deficient or abnormal distribution of myeloperoxidase (mpo), a gene specifically expressed in zebrafish granulocytes. One of the mutants identified in this screen is disrupted in fbxo5, a gene not previously identified as having a role in hematopoiesis. Using whole mount RNA in situ analysis on mutant and morpholino-injected embryos (morphants) we have determined that decreased levels of fbxo5 result in severely diminished numbers of granulocytes, although erythropoiesis appears normal. Interestingly, fbxo5 morphants have normal levels of pu.1 and l-plastin expression. Since we have previously shown that knockdown of pu.1 results in the loss of mpo-expressing cells, our data suggest that fbxo5 may function downstream or in a parallel pathway to pu.1 during granulopoiesis. To determine if the decreased number of granulocytes was due to programmed cell death, we examined the level of apoptosis in morphant versus control embryos. Whole mount acridine orange staining of apoptotic cells indicated that fbxo5 morphants had increased apoptosis, which can be mostly rescued by co-injection with p53 morpholino. However, the fbxo5/p53 double morphants continued to display a severe decrease in granulocytes, suggesting that the loss of granulocytes is not due to p53-mediated apoptosis. Fbxo5 has been examined previously in Xenopus oocytes, where the protein was found to regulate cell cycle progression by inhibiting APC. Interestingly, we have identified multiple mutants in genes that normally regulate the G2/M checkpoint and mitosis during the cell cycle all which display decreased numbers of granulocytes, suggesting a role for the regulation of the cell cycle in granulopoiesis. While further analysis is needed to determine where and how fbxo5 functions during myeloid cell development, as well as each of the genes disrupted in our additional cell cycle mutants, we have identified that fbxo5 is necessary specifically for the normal development of granulocytes.

Applying the Anderson-Darling Test to Suicide Clusters

Crisis ◽  
2013 ◽  
Vol 34 (6) ◽  
pp. 434-437 ◽  
Author(s):  
Donald W. MacKenzie
Keyword(s):  
Poisson Process ◽  
Goodness Of Fit ◽  
Small Samples ◽  
Massachusetts Institute Of Technology ◽  
Homogeneous Poisson Process ◽  
Cornell University ◽  
The Difference ◽  
Suicide Clusters ◽  
Institute Of Technology ◽  
Anderson Darling

Background: Suicide clusters at Cornell University and the Massachusetts Institute of Technology (MIT) prompted popular and expert speculation of suicide contagion. However, some clustering is to be expected in any random process. Aim: This work tested whether suicide clusters at these two universities differed significantly from those expected under a homogeneous Poisson process, in which suicides occur randomly and independently of one another. Method: Suicide dates were collected for MIT and Cornell for 1990–2012. The Anderson-Darling statistic was used to test the goodness-of-fit of the intervals between suicides to distribution expected under the Poisson process. Results: Suicides at MIT were consistent with the homogeneous Poisson process, while those at Cornell showed clustering inconsistent with such a process (p = .05). Conclusions: The Anderson-Darling test provides a statistically powerful means to identify suicide clustering in small samples. Practitioners can use this method to test for clustering in relevant communities. The difference in clustering behavior between the two institutions suggests that more institutions should be studied to determine the prevalence of suicide clustering in universities and its causes.

Editorial: Advancing the Debate on Architecture, Planning, and Built Environment Research

2015 ◽  
Vol 9 (2) ◽  
Author(s):  
Ashraf M. Salama
Keyword(s):  
Learning Styles ◽  
Cultural Values ◽  
Urban Studies ◽  
Wide Spectrum ◽  
Journal Ranking ◽  
Massachusetts Institute Of Technology ◽  
Open Access Journals ◽  
Practice Based Research ◽  
Institute Of Technology ◽  
Number Of Citations

With an acceptance rate that does not exceed 25% of the total papers and articles submitted to the journal, IJAR – International Journal of Architectural Research is moving forward to position itself among the leading journals in architecture and urban studies worldwide. As this is the case since the beginning of volume 5, issue 1, March 2011, one must note that the journal has been covered by several data and index bases since its inception including Avery Index to Architectural Periodicals, EBSCO-Current Abstracts-Art and Architecture, INTUTE, Directory of Open Access Journals, Pro-Quest, Scopus-Elsevier and many university library databases across the globe. This is coupled with IJAR being an integral part of the archives and a featured collection of ArchNet and the Aga Khan Documentation Centre at MIT: Massachusetts Institute of Technology, Cambridge, MA.In 2014, IJAR was included in Quartile 2 / Q2 list of Journals both in ‘Architecture’ and ‘Urban Studies.’ As of May 2015, IJAR is ranked 23 out of 83 journals in ‘Architecture’ and 59 out of 119 in ‘Urban Studies.’ Rankings are based on the SJR (SCImago Journal Ranking); an Elsevier- SCOPUS indicator that measures the scientific influence of the average article in a journal. SJR is a measure of scientific influence of scholarly journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from. See here for more information (http://www.scimagojr.com/index.php) and (http://www.journalmetrics.com/sjr.php). While the journal is now on top of many of the distinguished journals in Elsevier- SCOPUS database, we will keep aspiring to sustain our position and move forward to Q1 group list and eventually in the top 10 journal list in the field. However, this requires sustained efforts and conscious endeavours that give attention to quality submissions through a rigorous review process. This edition of IJAR: volume 9, issue 2, July 2015 includes debates on a wide spectrum of issues, explorations and investigations in various settings. The issue encompasses sixteen papers addressing cities, settlements, and projects in Europe, South East Asia, and the Middle East. Papers involve international collaborations evidenced by joint contributions and come from scholars in universities, academic institutions, and practices in Belgium; Egypt; Greece; Italy; Jordan; Malaysia; Palestine; Qatar; Saudi Arabia; Serbia; Spain; Turkey; and the United Kingdom. In this editorial I briefly outline the key issues presented in these papers, which include topics relevant to social housing, multigenerational dwelling, practice-based research, sustainable design and biomimetic models, learning environments and learning styles, realism and the post modern condition, development and planning, urban identity, contemporary landscapes, and cultural values and traditions.

XX Rudi Dombusch, Keys to Prosperity. Free Markets, Sound Money, and bit of Luck The MIT Press 2000 Londres

2009 ◽  
Vol 33 (130) ◽  
Author(s):  
GERARDO REYES GUZMÁN
Keyword(s):  
Massachusetts Institute ◽  
Massachusetts Institute Of Technology ◽  
Free Markets ◽  
Institute Of Technology

Rudiger Dornbusch, destacado economista del Massachusetts Institute of Technology (MIT), analiza en esta trascendental obra tópicos como inflación, deuda, tipos de cambio, política externa y mercados emergentes. El marco conceptual descansa en la corriente de la escuela de Chicago, la cual parte del principio de que el mercado es el mecanismo que garantiza la creación del progreso en contraste con el Estado, que en su afán por encontrar soluciones perfectas, fracasa regularmente en sus cometidos.

Life sciences intellectual property licensing at the Massachusetts Institute of Technology

2021 ◽  
Vol 39 (3) ◽  
pp. 293-301
Author(s):  
Samuel Huang ◽  
Kien Wei Siah ◽  
Detelina Vasileva ◽  
Shirley Chen ◽  
Lita Nelsen ◽  
...  
Keyword(s):  
Intellectual Property ◽  
Life Sciences ◽  
Massachusetts Institute ◽  
Massachusetts Institute Of Technology ◽  
Institute Of Technology
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