Clinicopathological, molecular features and prognosis of colorectal cancer with mucinous component

2020 ◽  
Author(s):  
Jianxia Li ◽  
Liu Yang ◽  
Fan Bai ◽  
Yue Cai ◽  
Jianwei Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Multivariable Analysis ◽  
Clinicopathological Characteristics ◽  
Primary Tumors ◽  
Pik3ca Mutations ◽  
Dna Mismatch ◽  
Molecular Features ◽  
Mucinous Component ◽  
Repair Protein ◽  
Mismatch Repair Protein

Background: Colorectal cancer (CRC) with mucinous component is associated with distinct characteristics and controversial prognosis. Patients & methods: A total of 1800 CRC patients were retrospectively enrolled and grouped by the mucinous content of the primary tumors. The clinicopathological characteristics and overall survival rate were compared between groups. Results: Mucinous adenocarcinoma (MAC) and adenocarcinoma with mucinous component (AMC) had higher frequencies of DNA mismatch repair protein deficiency, KRAS, BRAF and PIK3CA mutations as compared to those of conventional adenocarcinoma (CAC). MAC had worse prognosis than CAC. However, MAC was not an independent prognostic factor in multivariable analysis. Conclusion: Molecular features of AMC and MAC were similar, which were different from those of CAC. Neither MAC nor AMC were independent prognostic factors for CRC.

scholarly journals Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis

2008 ◽  
Vol 29 (6) ◽  
pp. 1290-1297 ◽  
Author(s):  
Ruben van Boxtel ◽  
Pim W. Toonen ◽  
Henk S. van Roekel ◽  
Mark Verheul ◽  
Bart M. G. Smits ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals DNA Mismatch Repair Protein Msh6 Is Required for Optimal Levels of Ultraviolet-B-Induced Apoptosis in Primary Mouse Fibroblasts

2003 ◽  
Vol 121 (4) ◽  
pp. 876-880 ◽  
Author(s):  
Leah C. Young ◽  
Anthea C. Peters ◽  
Tomoko Maeda ◽  
Winfried Edelmann ◽  
Raju Kucherlapati ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Ultraviolet B ◽  
Mouse Fibroblasts ◽  
Dna Mismatch ◽  
Repair Protein ◽  
Primary Mouse ◽  
Induced Apoptosis ◽  
Mismatch Repair Protein

scholarly journals Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

2007 ◽  
Vol 35 (8) ◽  
pp. 2609-2619 ◽  
Author(s):  
Nina Østergaard Knudsen ◽  
Finn Cilius Nielsen ◽  
Lena Vinther ◽  
Ronni Bertelsen ◽  
Steen Holten-Andersen ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Nuclear Localization ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Human Dna ◽  
Repair Protein ◽  
Exonuclease 1 ◽  
Mismatch Repair Protein

scholarly journals The Bloom's Syndrome Helicase Interacts Directly with the Human DNA Mismatch Repair Protein hMSH6

2003 ◽  
Vol 384 (8) ◽  
Author(s):  
G. Pedrazzi ◽  
C. Z. Bachrati ◽  
N. Selak ◽  
I. Studer ◽  
M. Petkovic ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Bloom's Syndrome ◽  
Dna Mismatch ◽  
Human Dna ◽  
Repair Protein ◽  
Bloom’S Syndrome ◽  
Mismatch Repair Protein
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