scholarly journals Inactivation of X-linked tumor suppressor genes in human cancer

2012 ◽  
Vol 8 (4) ◽  
pp. 463-481 ◽  
Author(s):  
Runhua Liu ◽  
Mandy Kain ◽  
Lizhong Wang
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Human Cancer ◽  
Suppressor Genes

scholarly journals Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells

2010 ◽  
Vol 9 (11) ◽  
pp. 3015-3023 ◽  
Author(s):  
Dirk Kuck ◽  
Thomas Caulfield ◽  
Frank Lyko ◽  
Jose L. Medina-Franco
Keyword(s):  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Human Cancer ◽  
Suppressor Genes ◽  
Human Cancer Cells

scholarly journals Recent Progress in Mouse Models for Tumor Suppressor Genes and its Implications in Human Cancer

2013 ◽  
Vol 7 ◽  
pp. CMO.S10358 ◽  
Author(s):  
Kazushi Inoue ◽  
Elizabeth A. Fry ◽  
Pankaj Taneja
Keyword(s):  
Tumor Suppressor ◽  
Mouse Models ◽  
Tumor Suppressor Genes ◽  
Therapeutic Potential ◽  
Human Cancer ◽  
Loss Of Function ◽  
Oncogenic Signaling ◽  
Suppressor Genes ◽  
Somatic Tissues ◽  
Oncogenic Signaling Pathways

Gain-of-function mutations in oncogenes and loss-of-function mutations in tumor suppressor genes (TSG) lead to cancer. In most human cancers, these mutations occur in somatic tissues. However, hereditary forms of cancer exist for which individuals are heterozygous for a germline mutation in a TSG locus at birth. The second allele is frequently inactivated by gene deletion, point mutation, or promoter methylation in classical TSGs that meet Knudson's two-hit hypothesis. Conversely, the second allele remains as wild-type, even in tumors in which the gene is haplo-insufficient for tumor suppression. This article highlights the importance of PTEN, APC, and other tumor suppressors for counteracting aberrant PI3K, β-catenin, and other oncogenic signaling pathways. We discuss the use of gene-engineered mouse models (GEMM) of human cancer focusing on Pten and Apc knockout mice that recapitulate key genetic events involved in initiation and progression of human neoplasia. Finally, the therapeutic potential of targeting these tumor suppressor and oncogene signaling networks is discussed.

scholarly journals A Profile of Methyl-CpG Binding Domain Protein Occupancy of Hypermethylated Promoter CpG Islands of Tumor Suppressor Genes in Human Cancer

2006 ◽  
Vol 66 (17) ◽  
pp. 8342-8346 ◽  
Author(s):  
Lidia Lopez-Serra ◽  
Esteban Ballestar ◽  
Mario F. Fraga ◽  
Miguel Alaminos ◽  
Fernando Setien ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Human Cancer ◽  
Cpg Islands ◽  
Binding Domain ◽  
Suppressor Genes ◽  
Protein Occupancy ◽  
Domain Protein
Sign in / Sign up

Export Citation Format

Share Document