Albumin-based lipoprotein nanoparticles for improved delivery and anticancer activity of curcumin for cancer treatment

Nanomedicine ◽  
2020 ◽  
Vol 15 (29) ◽  
pp. 2851-2869 ◽  
Author(s):  
Preeti Kumari ◽  
Milan Paul ◽  
Yamini Bobde ◽  
Kumbham Soniya ◽  
Sri Vishnu Kiran Rompicharla ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Breast Cancer Cells ◽  
Drug Loading ◽  
Human Breast ◽  
Treatment Alternative ◽  
Albumin Nanoparticles ◽  
Tumor Bearing

Aim: To prepare curcumin (CUR)-loaded, dioleoyl phosphoethanolamine-conjugated human serum albumin nanoparticles (NPs) and to evaluate their effectiveness in breast cancer therapy. Materials & methods: The CUR-loaded NPs were physicochemically characterized and evaluated for their cytotoxicity in murine (4T1) and human breast cancer (MDA-MB-231) cell lines. The antitumor efficacy of the nanomedicine was evaluated in 4T1 tumor bearing mice. Results: The prepared NPs exhibited encapsulation and drug loading efficiencies of approximately 79 and 21%, respectively. The NPs were taken up efficiently and markedly hindered the proliferation of breast cancer cells compared with free drug. NPs exhibited greater suppression of tumor growth in 4T1 tumor bearing mice. Conclusion: CUR-human serum albumin-dioleoyl phosphoethanolamine NPs could be a potential treatment alternative for solid tumors, including breast cancer.

Regulation of BAX/BCL2 gene expression in breast cancer cells by docetaxel-loaded human serum albumin nanoparticles

2015 ◽  
Vol 32 (7) ◽  
Author(s):  
Marzieh Kordezangeneh ◽  
Shiva Irani ◽  
Reza Mirfakhraie ◽  
Mehdi Esfandyari-Manesh ◽  
Fatemeh Atyabi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Albumin Nanoparticles ◽  
Bcl2 Gene

Specific Targeting of HER2 Overexpressing Breast Cancer Cells with Doxorubicin-Loaded Trastuzumab-Modified Human Serum Albumin Nanoparticles

2008 ◽  
Vol 19 (12) ◽  
pp. 2321-2331 ◽  
Author(s):  
Marion G. Anhorn ◽  
Sylvia Wagner ◽  
Jörg Kreuter ◽  
Klaus Langer ◽  
Hagen von Briesen
Keyword(s):  
Breast Cancer ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Specific Targeting ◽  
Albumin Nanoparticles

The in vivo antitumor activity of LHRH targeted methotrexate–human serum albumin nanoparticles in 4T1 tumor-bearing Balb/c mice

2012 ◽  
Vol 431 (1-2) ◽  
pp. 183-189 ◽  
Author(s):  
Azade Taheri ◽  
Rassoul Dinarvand ◽  
Fatemeh Ahadi ◽  
Mohammad Reza Khorramizadeh ◽  
Fatemeh Atyabi
Keyword(s):  
Human Serum Albumin ◽  
Antitumor Activity ◽  
Serum Albumin ◽  
Human Serum ◽  
Albumin Nanoparticles ◽  
Tumor Bearing ◽  
In Vivo Antitumor Activity

Adsorption of obidoxime onto human serum albumin nanoparticles: Drug loading, particle size and drug release

2010 ◽  
Vol 27 (6) ◽  
pp. 506-513 ◽  
Author(s):  
Jürgen Kufleitner ◽  
Sylvia Wagner ◽  
Franz Worek ◽  
Hagen von Briesen ◽  
Jörg Kreuter
Keyword(s):  
Particle Size ◽  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Loading ◽  
Albumin Nanoparticles
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