Cell-based drug-delivery systems: a possible solution to improve nanomedicine for cancer treatment?

Nanomedicine ◽  
2022 ◽  
Author(s):  
Wei-Jen Chan ◽  
Huatian Li ◽  
Sina Dehestani
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals “Smart” materials-based near-infrared light-responsive drug delivery systems for cancer treatment: A review

2019 ◽  
Vol 8 (1) ◽  
pp. 1497-1509 ◽  
Author(s):  
Ali Raza ◽  
Uzma Hayat ◽  
Tahir Rasheed ◽  
Muhammad Bilal ◽  
Hafiz M.N. Iqbal
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Smart Materials ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Infrared Light ◽  
Near Infrared Light

scholarly journals Use of Bacterial Ghosts as Novel Drug Delivery Systems to Improve Cancer Treatment

2016 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Amin Afkhami-Poustchi ◽  
Maryam M Matin
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Bacterial Ghosts ◽  
Novel Drug

Recent Progress in Stimuli Responsive Intelligent Nano Scale Drug Delivery Systems: A special focus towards pH sensitive systems

2021 ◽  
Vol 22 ◽  
Author(s):  
Vaidevi Sethuraman ◽  
Kumar Janakiraman ◽  
Venkateshwaran Krishnaswami ◽  
Ruckmani Kandasamy
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Special Focus ◽  
Stimuli Responsive ◽  
Ph Variation ◽  
Responsive Systems

Abstract: Stimuli responsive nanocarriers are gaining much attention due to its versatile multifunctional activities including disease diagnosis and treatment. Recently, clinical applications of nano drug delivery systems for cancer treatment make a considerable challenge due to its limited cellular uptake, low bioavailability, poor targetability, stability issues, and unfavourable pharmacokinetics. To overcome these issues researchers are focussing on stimuli responsive systems. Nano carriers elicit its role through endogenous (pH, temperature, enzyme and redox) or exogenous (temperature, light, magnetic field, ultrasound) stimulus. These systems were designed to overcome the shortcomings such as non-specificity and toxicity associated with the conventional drug delivery systems. The pH variation between healthy cells and tumor microenvironment creates a platform towards the generation of pH sensitive nano delivery systems. Herein, we propose to present an overview of various internal and external stimuli responsive behavior based drug delivery systems. Herein the present review will focus specifically on the significance of various pH- responsive nanomaterials such as polymeric nanoparticles, nano micelles, inorganic based pH sensitive drug delivery carriers such as calcium phosphate nanoparticles, and carbon dots in cancer treatment. Moreover, this review elaborates the recent findings on pH based stimuli responsive drug delivery system with special emphasis towards our reported stimuli responsive systems for cancer treatment.

Redox Sensitive Polysaccharide Based Nanoparticles for Improved Cancer Treatment: A Comprehensive Review

2018 ◽  
Vol 24 (28) ◽  
pp. 3303-3319 ◽  
Author(s):  
Erfaneh Ghassami ◽  
Jaleh Varshosaz ◽  
Somayeh Taymouri
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Chemical Properties ◽  
Delivery Systems ◽  
Exchange Reactions ◽  
Triggered Release ◽  
Redox Responsive

Background: Among the numerous bio-responsive polymeric drug delivery systems developed recently, redox-triggered release of molecular payloads have gained great deal of attention, especially in the field of anticancer drug delivery. In most cases, these systems rely on disulfide bonds located either in the matrix crosslinks, or in auxiliary chains to achieve stimuli-responsive drug release. These bonds keep their stability in extracellular environments, yet, rapidly break by thiol–disulfide exchange reactions in the cytosol, due to the presence of greater levels of glutathione. Polysaccharides are macromolecules with low cost, natural abundance, biocompatibility, biodegradability, appropriate physical and chemical properties, and presence of numerous functional groups which facilitate chemical or physical cross-linking. Methods: With regards to the remarkable advantages of polysaccharides, in the current study, various polysaccharide-based redox-responsive drug delivery systems are reviewed. In most cases the in vitro/in vivo effects of the developed system were also evaluated. Results: Considering the hypoxic and reducing nature of the tumor microenvironment, with several folds higher glutathione levels than the systemic tissues, redox-sensitive polymeric systems could be implemented for tumorspecific drug delivery and the results of the previous researches in this field indicated satisfactory achievements. Conclusion: According to the reviewed papers, the efficiency of diverse redox-responsive polysaccharide-based nanoparticles with therapeutic payloads in cancer chemotherapy could be concluded. Nevertheless, more comprehensive studies are required to understand the exact intracellular and systemic fate of these nano-carriers, as well as their clinical efficacy for cancer treatment.

Advances in local and systemic drug delivery systems for post-surgical cancer treatment

2020 ◽  
Vol 8 (37) ◽  
pp. 8507-8518
Author(s):  
Md Aquib ◽  
Ajkia Zaman Juthi ◽  
Muhammad Asim Farooq ◽  
Manasik Gumah Ali ◽  
Alhamzah Hasan Waheed Janabi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Graphical Representation ◽  
Delivery Systems ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Graphical representation of local and systemic drug delivery systems.

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