Sieving treatment biomarkers from blood gene-expression profiles: a pharmacogenomic update on two types of multiple sclerosis therapy

2011 ◽  
Vol 12 (3) ◽  
pp. 423-432 ◽  
Author(s):  
Robert H Goertsches ◽  
Uwe K Zettl ◽  
Michael Hecker
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Gene Expression ◽  
Multiple Sclerosis Therapy ◽  
Sclerosis Therapy

scholarly journals Identification of Monotonically Differentially Expressed Genes for IFN-β-Treated Multiple Sclerosis Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Suyan Tian ◽  
Lei Zhang
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Biologically Relevant ◽  
Therapeutic Mechanism ◽  
The Central Nervous System ◽  
Multiple Sclerosis Patients ◽  
Term Response

Multiple sclerosis (MS) is a common neurological disability of the central nervous system. Immune-modulatory therapy with interferon-β (IFN-β) has been used as a first-line treatment to prevent relapses in MS patients. While the therapeutic mechanism of IFN-β has not been fully elucidated, the data of microarray experiments that collected longitudinal gene expression profiles to evaluate the long-term response of IFN-β treatment have been analyzed using statistical methods that were incapable of dealing with such data. In this study, the GeneRank method was applied to generate weighted gene expression values and the monotonically expressed genes (MEGs) for both IFN-β treatment responders and nonresponders were identified. The proposed procedure identified 13 MEGs for the responders and 2 MEGs for the nonresponders, most of which are biologically relevant to MS. Our work here provides some useful insight into the mechanism of IFN-β treatment for MS patients. A full understanding of the therapeutic mechanism will enable a more personalized treatment strategy possible.

Alterations in neuronal gene expression profiles in response to experimental demyelination and axonal transection

2010 ◽  
Vol 16 (3) ◽  
pp. 303-316 ◽  
Author(s):  
G. Lovas ◽  
JA Nielsen ◽  
KR Johnson ◽  
LD Hudson
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Neurological Deficits ◽  
Activating Transcription Factor 3 ◽  
Post Intervention ◽  
Neuronal Gene ◽  
Activating Transcription Factor ◽  
Axonal Transection

The main pathological features of multiple sclerosis, demyelination and axonal transection, are considered to cause reversible and irreversible neurological deficits, respectively. This study aimed to separately analyze the effects of these pathological hallmarks on neuronal gene expression in experimental paradigms. The pontocerebellar pathway was targeted with either lysolecithin-induced chemical demyelination or a complete pathway transection (axonal transection) in rats. Transcriptional changes in the pontocerebellar neurons were investigated with microarrays at days 4, 10 and 37 post-intervention, which was confirmed by immunohistochemistry on protein level. A common as well as unique set of injury-response genes was identified. The increased expression of activating transcription factor 3 (Atf3) and thyrotropin-releasing hormone (Trh) in both injury paradigms was validated by immunohistochemistry. The expression of Atf3 in a patient with Marburg’s variant of multiple sclerosis was also detected, also confirming the activation of the Atf3 pathway in a human disease sample. It was concluded that this experimental approach may be useful for the identification of pathways that could be targeted for remyelinative or neuroprotective drug development.

scholarly journals Whole Blood Gene Expression Profiles in Insulin Resistant Latinos with the Metabolic Syndrome

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e84002 ◽  
Author(s):  
Samantha E. Tangen ◽  
Darwin Tsinajinnie ◽  
Martha Nuñez ◽  
Gabriel Q. Shaibi ◽  
Lawrence J. Mandarino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Whole Blood ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Gene Expression ◽  
Insulin Resistant ◽  
The Metabolic Syndrome

Predose Blood Gene Expression Profiles Might Identify the Individuals Susceptible to Carbon Tetrachloride–Induced Hepatotoxicity

2010 ◽  
Vol 115 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Jun-Won Yun ◽  
Tae-Ryong Lee ◽  
Chae-Wook Kim ◽  
Young-Ho Park ◽  
Jin-Ho Chung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Carbon Tetrachloride ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Gene Expression
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