Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of conotruncal heart defects
Keyword(s):
Aim: Conotruncal heart defects (CTDs) are the most common form of congenital heart disease. We investigated the association of these two single-nucleotide polymorphisms (SNPs) in the promoter of miR-143/145 (rs353292 and rs4705343) with the susceptibility to CTDs in a Chinese population. Materials & methods: Two SNPs in the promoter of miR-143/145 (rs353292 and rs4705343) have been examined by PCR-RFLP methodology for 259 CTDs patients and 303 control subjects. Results: An association between SNP rs4705343 of miR-143/145 and CTDs has been confirmed in the Chinese Han population. Conclusion: Our results indicated that SNP rs4705343 in miR-143/145 is a potential genetic marker for CTDs in the Chinese Han population.
2020 ◽
2014 ◽
Vol 21
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pp. 8-14
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2020 ◽
Vol 70
(8)
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pp. 1282-1292
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2017 ◽
Vol 39
(8)
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pp. 748-753
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