Regeneration of mandibular osteoradionecrosis with autologous cross-linked serum albumin scaffold

Osteoradionecrosis is one of the most severe complications of radiotherapy administered for head and neck tumors. We present the first two cases of advanced and refractory mandibular osteoradionecrosis treated by application of a novel autologous cross-linked 3D serum matrix. Patients were followed clinically and radiographically up to 24 months. Complete wound healing and intact mucosal cover were achieved in both cases. At 12 months, the radiographic values showed an almost complete regeneration of the bone defect, which continued a favourable progression increased to the maximum by 24 months after surgery. The use of an autologous serum-derived scaffold proved to be a quick, predictable, cost-effective and safe adjunct to the conservative surgical treatment of this pathology.

Download Full-text

Surgical Treatment of Head and Neck Tumors

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1975.tb95109.x ◽

1975 ◽

Vol 2 (2) ◽

pp. 66-66

Author(s):

NORMAN R. WYNDHAM

Keyword(s):

Surgical Treatment ◽

Head And Neck ◽

Head And Neck Tumors ◽

Neck Tumors

Download Full-text

Surgical Treatment of Head and Neck Tumors

Archives of Surgery ◽

10.1001/archsurg.1975.01360130082029 ◽

1975 ◽

Vol 110 (7) ◽

pp. 850

Author(s):

GEORGE RICHARDSON

Keyword(s):

Surgical Treatment ◽

Head And Neck ◽

Head And Neck Tumors ◽

Neck Tumors

Download Full-text

Biopolymeric materials for targeted drug delivery in the therapy accompanying radiation treatment of patients with head and neck tumors

Nauchno-prakticheskii zhurnal «Patogenez» ◽

10.25557/2310-0435.2018.01.76-82 ◽

2018 ◽

pp. 76-82

Author(s):

А.В. Бойко ◽

А.Р. Геворков ◽

Н.Д. Олтаржевская ◽

В.И. Швец ◽

С.В. Шашков

Keyword(s):

Drug Delivery ◽

Wound Healing ◽

Head And Neck ◽

Radiation Treatment ◽

Supportive Therapy ◽

Head And Neck Tumors ◽

Local Drug Delivery ◽

Optimal Timing ◽

Neck Tumors ◽

Key Factor

В работе освещены основные вопросы эффективности и переносимости лучевого и химиолучевого лечения больных опухолями головы и шеи. Представлен спектр побочных эффектов и затронуты ключевые аспекты терапии сопровождения. Особое внимание уделено роли местной ранозаживляющей терапии в борьбе с мукозитом и дерматитом в рамках обеспечения оптимальных сроков лучевой терапии, а также сохранения качества жизни пациентов на всех этапах их лечения и реабилитации. Отдельно описаны возможности эффективной местной доставки лекарственных средств путем применения отечественных биополимерных наноматериалов. Так, использование биополимера альгината натрия в качестве матрицы в сочетании с деринатом позволило получить необходимый ранозаживляющий эффект, а добавление других лекарственных наделило препарат противоинфекционным, обезболивающим, антиоксидантным, либо радиомодифицирующим действием. Применение адекватной терапии сопровождения с ранозаживляющим компонентом позволяет соблюдать оптимальные сроки лечения, что было достоверно показано на собственном опыте. The study highlighted major aspects of efficacy and tolerability of radiation and chemoradiation treatment in patients with head and neck tumors. A range of side effects is presented and key aspects of supportive care are discussed. Particular attention was paid to local wound healing as the main cure for mucositis and dermatitis and key factor for optimal timing of radiotherapy as well as to preserving patients’ quality of life. Possibilities for effective local drug delivery using biopolymeric nanomaterials are described. Thus, the use of biopolymeric sodium alginate as a matrix in combination with derinate allowed to achieve the required wound-healing effect. Addition of other drugs provided anti-infection, analgesic, antioxidant or radiomodifying effects. Appropriate supportive therapy in combination with a wound healing component allows to adhere to the optimal treatment duration, as our experience has convincingly demonstrated.

Download Full-text