scholarly journals Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI)

2015 ◽  
Vol 10 (2s) ◽  
pp. 1-44 ◽  
Author(s):  
PW Andrews ◽  
D Baker ◽  
N Benvinisty ◽  
B Miranda ◽  
K Bruce ◽  
...  
2017 ◽  
Vol 6 (11) ◽  
pp. 1956-1962 ◽  
Author(s):  
Jung-Hyun Kim ◽  
Andreas Kurtz ◽  
Bao-Zhu Yuan ◽  
Fanyi Zeng ◽  
Geoff Lomax ◽  
...  

2014 ◽  
Vol 3 (5) ◽  
pp. 586-598 ◽  
Author(s):  
Hong-Kee Tan ◽  
Cheng-Xu Delon Toh ◽  
Dongrui Ma ◽  
Binxia Yang ◽  
Tong Ming Liu ◽  
...  

2018 ◽  
pp. 257-269
Author(s):  
Robert Briddell ◽  
Frank Litkenhaus ◽  
James E. Carroll ◽  
Mohammed Ali ◽  
Kate F. Girard ◽  
...  

Medicina ◽  
2019 ◽  
Vol 55 (6) ◽  
pp. 244
Author(s):  
Fatima A. Saleh

Background: Umbilical cord blood (UCB) used to be considered waste material and was discarded at birth. However, cord blood is now considered a rich source of adult stem cells that can be used to treat many conditions and diseases. This study was performed to determine pregnant women’s knowledge and attitudes toward cord blood stem cell banking and donation in Lebanon. Methods: A descriptive study was conducted in antenatal clinics in Beirut and data were collected using a questionnaire distributed to pregnant women after provision of informed consent. A total of 244 women responded. Results: Less than half of the women (46%) reported knowledge about cord blood banking. However, participants with university and secondary education had significantly higher odds of considering UCB storage compared to those with primary education (odds ratio (OR) 8.62, 95% confidence interval (CI) 2.74–27.15 and OR 21.23,95% CI 6.55–68.86, respectively). Older pregnant women were less likely to think about UCB stem cells storage (OR 0.92, 95% CI 0.85–0.98). Conclusion: Respondents who had an existing knowledge about UCB stem cells banking in general were more likely to consider storing UCB in blood banks if affordable (45.9%). Therefore, it is necessary to inform pregnant women about stem cell banking so that they can make the appropriate decisions for themselves.


Author(s):  
S. Tamir Rashid ◽  
Ludovic Vallier

Following Shinya Yamanaka's first report describing the reprogramming of fibroblasts into stem cells over three years ago, some sceptics initially drew analogies between this new field of research and the quasi-mystical practice of ‘alchemy’. Unlike the alchemist, however, stem cell researchers have rigorously tested and repeated experiments, proving their very own brand of cellular ‘alchemy’ to be a reality, with potentially massive implications for the study of human biology and clinical medicine. These investigations have resulted in an explosion of related publications and initiated the field of stem cell research known as ‘induced pluripotency’. In this review, we give an account of the historical development, current technologies and potential clinical applications of induced pluripotency and conclude with a perspective on the possible future directions for this dynamic field.


2019 ◽  
Vol 14 (4) ◽  
pp. 367-372
Author(s):  
David T Harris ◽  
Scott Israel

Cord Blood (CB) is a unique and readily available source of hematopoietic stem cells for transplantation. CB also contains other types of stem cells, including endothelial stem cells and mesenchymal stem cells, that may prove useful in non-traditional clinical uses. Genetic and molecular analyses have demonstrated that CB stem cells lie somewhere between mature stem cells like those found in Bone Marrow (BM), and fetal stem cells. After 25 years of clinical experience, CB is now used in the same fashion as BM for all typical malignant and genetic diseases treated by bone marrow transplant. Due to the establishment of CB banks in the US and abroad, more than 35,000 CB transplants have been performed over the past 25 years. An average of 700-800 CB transplants are performed annually. In addition, CB is now used more frequently for regenerative medicine and tissue engineering applications. At first glance, it seems that everything could not be better with the public cord blood banks and the use of their samples in the clinic. However, a recent report by the Rand Corp. reviewed the US national cord blood stem cell banking program and detailed many ongoing problems. However, some details were omitted from the report that would shed some light on the causes of many of the problems. This paper will summarize the status of the public cord blood stem cell banking program in the US, detail the problems associated with the program that could jeopardize its existence and suggest possible solutions to resolve these issues.


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