scholarly journals Mupirocin Resistance in Staphylococcus aureus Isolated from Nasal Swabs of ICU and OT Staff- A Study from A Tertiary Care Hospital

2021 ◽  
Author(s):  
Sapna Chauhan ◽  
Surender ◽  
Tony J Rappai
Keyword(s):  
Health Care ◽  
Staphylococcus Aureus ◽  
Health Care Workers ◽  
Tertiary Care ◽  
Nasal Carriage ◽  
Diffusion Method ◽  
Care Hospital ◽  
Care Workers ◽  
Nasal Swabs ◽  
Mupirocin Resistance

Staphylococcus aureus is one of the common causes of Healthcare-associated infection. Staphylococcus colonizes the anterior nares of the nose and tends to disseminate and secondarily colonize several other body sites including the skin and the gut. Colonized hospital personnel may be an important factor in dissemination. Staphylococcus aureus to patients and vice-versa. Mupirocin is an excellent topical anti-staphylococcal antimicrobial agent used for eradicating nasal carriage. Resistance to Mupirocin is a threat for future use of this drug in eliminating nasal carriage of Staphylococcus aureus. Thus, this study was conducted to determine the rate of Mupirocin resistance among Staphylococcus aureus isolated from nasal swabs of Health care workers (HCWs ) of Operation Theatres (OTs) and Intensive Care Units (ICUs). A single nasal swab was collected from both the anterior nares of participating health care workers of ICU and OT once at the end of their shift. Antibiotic susceptibility testing of Staphylococcus aureus to various antibiotics was done by Kirby-Bauer disk diffusion method using CLSI guidelines. High and low-level Mupirocin resistance was determined. Among 282 nasal swabs collected, Staphylococcus aureus was isolated in 62 samples. Of Staphylococcus aureus 19 came out to be Methicillin-resistant (MRSA) and the remaining 43 Methicillin sensitive (MSSA). Mupirocin resistance was seen in 3 MRSA strains and 1 MSSA strain. Thus, overall 4/62 (6.5%) strains were MupR strains. Mupirocin is the most effective antibiotic used against colonization of Staphylococcus aureus in anterior nares. Resistance to this antibiotic is thus an alarm as well as a matter of great concern. Necessary steps, policies and guidelines need to be framed to stop the spread of this resistance.

scholarly journals Screening for nasal carriage Staphylococcus aureus and their antibiotic susceptibility pattern among the health care workers in a tertiary care hospital, Nepal

2018 ◽  
Vol 7 (2) ◽  
pp. 64-67
Author(s):  
Beena Jha ◽  
J Sapkota ◽  
M Sharma ◽  
B Mishra ◽  
CP Bhatt
Keyword(s):  
Health Care ◽  
Staphylococcus Aureus ◽  
Health Care Workers ◽  
Tertiary Care ◽  
College Teaching ◽  
Nasal Carriage ◽  
Hospital Environment ◽  
Care Hospital ◽  
Methicillin Resistant ◽  
Care Workers

Background: The presence of Staphylococcus aureus in anterior nares of health care workers may serve as a major source of infection in hospital environment and act as a reservoir for the spread of Methicillin Resistant S. aureus between patients.Objective: The present study was conducted to determine the frequency of nasal carriage of S. aureus among the health care workers of Kathmandu Medical College Teaching Hospital and to assess the antibioticsusceptibility patterns of the Methicillin Resistant S. aureus isolates.Methodology: A total of 200 health care workers involved in the management of patients from the intensive care unit, Operation Theatre, postoperative wards, different wards and emergency department were screened for S. aureus by collecting their nasal swabs.Results: Out of 200 health care workers, only 10(5%) were S. aureus nasal carriers. Out of 10 S. aureus strains isolated six (60%) were methicillin sensitive S. aureuswhereas four (40%) were methicillin resistant S. aureus. The isolates were 100% sensitive to Linezolid, Vancomycin and Amikacin but showed highest resistant to Azithromycin (100%), followed by Cefixime (60%).Conclusion: This study concluded that 5% of health care workers were S. aureus carriers and proportion of Methicillin Resistant S. aureus and Methicillin sensitive S. aureus was 60% and 40% respectively.Journal of Kathmandu Medical CollegeVol. 7, No. 2, Issue 24, Apr.-Jun., 2018, page: 64-67

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