scholarly journals THE ANALYSIS OF THE ASSOCIATION OF ADRB2 GENE POLYMORPHISM AND EXTERNAL RESPIRATORY FUNCTION IN CHILDREN WITH BRONCHIAL ASTHMA

2021 ◽  
Vol 20 (2) ◽  
pp. 71-76
Author(s):  
E.S. Minina ◽  
◽  
V.I. Novikova ◽  
P.D. Novikov ◽  
A.S. Babenka ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Respiratory Function ◽  
Gene Locus ◽  
Subjective Assessment ◽  
Control Test ◽  
Asthma Control Test ◽  
Individual Program ◽  
Adrb2 Gene

Objectives. To study the role of the ADRB2 gene polymorphism (rs1042713) in the impaired external respiratory function in children with bronchial asthma (BA). Material and methods. The study group included 60 children aged 3-17 years with allergic (n=37) and mixed form of BA (n=23). The genotyping of the investigated gene locus was performed by PCR-RFLP (polymerase chain reaction - restriction fragment length polymorphism), BA control was exercised using the Asthma Control Test (ACT). Results. The analysis of allele frequencies showed an association of allele A with normal spirogram parameters in patients with BA (p=0.042). In children under 12 years, there were statistically significant differences in spirogram indices when comparing patients with genotypes AA and GG (p=0.045). An association of allele A with the absence of pathological changes was revealed when evaluating the results of spirometry (p=0.021). There was a moderate positive correlation (r=0.615, p=0.011) between the assessment of nocturnal symptoms (Asthma Control Test) and the genotype of the ADRB2 gene polymorphism in children aged 12 years and older. Conclusions. An association of the ADRΒ2 gene polymorphism (rs1042713) with the external respiratory function was revealed in an objective study by spirometry and a subjective assessment of this indicator by the patient himself/herself or by his/her parents. This gene locus can be included in the BA target panel in order to determine the likelihood of uncontrolled course development of the disease with impaired external respiratory function and in the future to develop an individual program for dispensary observation of the patient.

scholarly journals Correlation Between the Asthma Control Test Score and FEV1 in Nigerians With Bronchial Asthma

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 146A
Author(s):  
Obianuju B. Ozoh ◽  
Olarenwaju E. Bandele ◽  
Cyril Chukwu ◽  
Njideka Okubadejo
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Test Score ◽  
Control Test ◽  
Asthma Control Test

scholarly journals Role of a Community Pharmacy Service in Care of Bronchial Asthma Patients in Lithuania

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Arturas Nastaravičius ◽  
Kristina Ramanauskienė
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Pharmacy Service ◽  
Control Test ◽  
Asthma Control Test ◽  
Chronic Respiratory Diseases ◽  
Asthmatic Patients ◽  
Positive Effects ◽  
Community Pharmacy Service ◽  
Asthma Patients

Bronchial asthma is one of the most common chronic respiratory diseases, and its care is often complex. In this research, we tested the proposal that participation of pharmacists in the management of bronchial asthma can improve patient outcomes. A two-stage study was constructed consisting of a training element and a service element, using the Asthma Control Test and a structured questionnaire about the patients’ disease condition (based on the results of a qualitative study). The study was conducted in 21 pharmacies in Lithuania and involved 338 asthmatic patients (age 18–88 years). It was found that before the pharmacy service was provided, the average number of mistakes patients made in administration of asthma medications was 2.03; this number decreased to 1.12 after the service was provided (p<0.05). Disease control paralleled the improvement in number of mistakes: 26.1% of patients who previously exerted no control over the disease symptoms began to exert sufficient control over their asthma symptoms (Asthma Control Test >20) after the service was provided (p<0.05). The reduced number of mistakes probably can be attributed to the positive effects of the provided services. By reducing the number of patient mistakes, pharmacists may improve the outcomes of asthmatic patients.

scholarly journals Effect of t reat ment of parasite s a nd inte stinaldisbiosis in t he c ourse of a sthma

2011 ◽  
Vol 8 (5) ◽  
pp. 16-20
Author(s):  
V K Yakovleva ◽  
Gleb Borisovich Fedoseev ◽  
M V Eliseeva ◽  
V I Trofimov ◽  
V K Yakovleva ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Bronchial Asthma ◽  
Respiratory Function ◽  
Control Group ◽  
Asthma Treatment ◽  
Control Test ◽  
Complex Treatment ◽  
Asthma Control Test ◽  
Basic Group ◽  
Before And After

Background. The results of observation of patients with bronchial asthma (ВА), parasitic invasion and intestine disbacteriosis before and after treatment have been described in the article. Methods. The basic group (ВА(+)) included 46 patients with ВА, parasitic invasion, disbacteriosis of intestine or their combination. The control group included 18 patients without disbacteriosis and parasitic invasion. The following examination was done: PS was assessed by ACTtest (asthma Control Test), respiratory function (RF ), helminthoovoscopy of faeces, P CR of faeces for lamblia Giardia, bacteriologic examination of faeces. Results. Complex treatment resulted in improvement of B A symptoms, decreased number of B A relapses and decreased number of hospitalization. Also the increasing of F EF 25 and F EF 50 was evaluated. S ame tendency was not traced in B A group and in patients with isolated lambliosis. Conclusion. Treatment of helminthiasis and intestine disbacteriosis improves the overall bronchial asthma treatment outcome.

Sign in / Sign up

Export Citation Format

Share Document