Assessment of the role of IL6 and IL10 gene polymorphisms as a risk factor for the development of restenosis in patients after implantation of drug-eluting stents

Relevance. Currently, the number of percutaneous coronary interventions continues to increase, which leads to an increase in the absolute number of restenosis cases, which is the main complication of the long-term postoperative period. The search for risk factors responsible for restenosis and artery re-narrowing mechanisms in order to prevent this complication is an important goal in interventional cardiology. Risk factors for the restenosis development include clinical, angiographic and genetic factors. An active search for biomolecular markers associated with the coronary artery restenosis is currently underway. Objective: to study the role of polymorphic variants C-174G of the IL6 gene and C-819T of the IL10 gene as a risk factor for the development of restenosis in patients after stent implantation. Materials and Methods : The study included 113 patients with stable coronary artery disease, who had previously undergone balloon angioplasty and implantation of drug-eluting stents, and 62 patients with intact arteries that were included to the control group. Statistical data processing was carried out using the R-language program and the SPSS Statistics 20 software package. Results: GG genotype for IL6 gene was associated with the development of coronary artery disease. In the subgroup of patients over 65 years of age and instent restenosis, the GG genotype was significantly less frequent. The homozygous CC genotype for IL10 gene was associated with rapid angiographic in-stent restenosis progression.

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Role of Second-Generation Drug-Eluting Stents and Bypass Grafting in Coronary Artery Disease: A Systematic Review and Meta-analysis

Cardiovascular Innovations and Applications ◽

10.15212/cvia.2016.0055 ◽

2017 ◽

Vol 2 (2) ◽

pp. 183-191

Author(s):

Linjuan Guo ◽

Ying Ding ◽

Fuwei Liu ◽

Wengen Zhu ◽

Xinghua Jiang

Keyword(s):

Systematic Review ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Second Generation ◽

Meta Analysis ◽

Drug Eluting Stents ◽

Bypass Grafting ◽

Drug Eluting ◽

Artery Disease

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Effect of Serum Homocysteine on Coronary Artery Disease in Younger and Older Ischaemic Heart Disease Patients

Cardiovascular Journal ◽

10.3329/cardio.v8i2.26817 ◽

2016 ◽

Vol 8 (2) ◽

pp. 138-142

Author(s):

Kazi Nazrul Islam ◽

Abdul Wadud Chowdhury ◽

Azizul Hasan Khondoker ◽

Md Serajul Haque ◽

KMN Sabah ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Risk Factor ◽

Heart Disease ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Homocysteine Level ◽

Serum Homocysteine ◽

Artery Disease

Background: Hyperhomocysteinemia is known as an independent risk factor of atherosclerosis. But the probable role of Hyperhomocysteinemia in Premature Coronary Artery Disease (CAD) is not well studied. The aim of this study was to assess the role of serum homocysteine on angiographically documented CAD in younger and older ischaemic heart disease (IHD) patients.Methods: Total 120 patients with IHD admitted in the Department of Cardiology, Dhaka Medical College Hospital for CAG were selected by purposive sampling method and divided into two groups. 60 patients in Group-I, d 40 years of age (Younger); 60 patients in Group-II, >40 years of age (Older). Homocysteine was measured in all patients and other demographical and clinical data were collected. Homocysteine level was correlated with the presence and severity of CAD.Results: Smoking, positive family history of IHD, dyslipidaemia and hyper homocysteinemia were important risk factors in younger IHD patients. Whereas, hypertension, diabetes mellitus and dyslipidaemia were important cardiovascular risk factors in older age group. Obesity was not an important risk factors as evidenced by mean BMI. Serum homocysteine was not well related to presence of CAD or extent of CAD in older IHD patients. However in younger patients hyperhomocysteinemia was related to both presence and severity of CAD.Conclusion: In younger IHD patients hyperhomocysteinemia is an important cardiovascular risk factor. But in older patients it loses its significance. So serum homocysteine level should be screened routinely in younger IHD patients.Cardiovasc. j. 2016; 8(2): 138-142

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Faculty Opinions recommendation of Drug-eluting stents versus coronary artery bypass grafting for the treatment of coronary artery disease: a meta-analysis of randomized and nonrandomized studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11983956.13110054 ◽

2011 ◽

Author(s):

Nawwar Al-Attar

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Meta Analysis ◽

Artery Bypass ◽

Drug Eluting Stents ◽

Bypass Grafting ◽

Drug Eluting ◽

Artery Disease

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Faculty Opinions recommendation of Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732060494.793539280 ◽

2017 ◽

Author(s):

Paulus Kirchhof

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Elderly Patients ◽

Drug Eluting Stents ◽

Blind Trial ◽

Drug Eluting ◽

Artery Disease ◽

Single Blind ◽

Single Blind Trial

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Association of smoking with coronary artery disease in Nepalese populations: a case control study

Toxicology Research ◽

10.1039/c9tx00083f ◽

2019 ◽

Vol 8 (5) ◽

pp. 677-685

Author(s):

Til Bahadur Basnet ◽

Cheng Xu ◽

Manthar Ali Mallah ◽

Wiwik Indayati ◽

Cheng Shi ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Risk Factor ◽

Coronary Artery ◽

Case Control Study ◽

Case Control ◽

Psychosocial Risk ◽

Psychosocial Risk Factor ◽

Artery Disease ◽

Control Study

Abstract There are well-known traditional risk factors for coronary artery disease (CAD). Among them, smoking is one of the most prominent and modifiable risk factors. This study aims to determine the magnitude of smoking as a risk factor for CAD in the Nepalese population. A hospital-based age- and sex-matched case–control study was carried out with a total of 612 respondents. Bivariate analysis showed that the risk of developing CAD in ex-smokers and current smokers was higher (odds ratio (OR): 1.81 (confidence interval (CI): 1.21–2.7) and OR: 5.2 (CI: 3.4–7.97)), with p-values less than 0.004 and <0.00001, respectively, compared to the risk in never smokers. From stratified socio-demographic, cardio-metabolic, behavioural and psychosocial risk factor analysis, smoking was found to be associated with CAD in almost all subgroups. In the subsequent multivariate analysis, adjustment for socio-demographic, cardio-metabolic and psychosocial risk factors showed a steady increase in risk. However, further adjustment for behavioural risk factors (alcohol use and physical activity) showed that the risk was attenuated by 59% in current smokers. After adjusting for the covariates, current smokers and ex-smokers had an increased risk of CAD (OR: 6.64, 95% CI: 3.64–12.12, p < 0.00001; OR: 1.89, 95% CI: 1.08–3.31, p < 0.012, respectively) compared with non-smokers. In conclusion, smoking was found to increase the risk of CAD in the Nepalese population.

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