Effect of silver nanoparticles synthesized from millingtonia hortensis on the antioxidant status in isoproterenol induced male wistar rats

2016 ◽  
Vol 7 (4) ◽  
Author(s):  
SAVITHA R ◽  
SARASWATHI U
Keyword(s):  
Silver Nanoparticles ◽  
Antioxidant Status ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Antioxidant status and hepato-protective role of Anchomanes difformis in streptozotocin-induced diabetes in male Wistar rats

2020 ◽  
Vol 66 (1) ◽  
pp. 18-36
Author(s):  
Toyin D. Alabi ◽  
Nicole L. Brooks ◽  
Oluwafemi O. Oguntibeju
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Aqueous Extract ◽  
Liver Dysfunction ◽  
Antioxidant Status ◽  
Wistar Rats ◽  
Serum Levels ◽  
Male Wistar Rats ◽  
Hepatic Injuries

SummaryIntroduction: The liver is involved in the metabolism of xenobiotics and their metabolites and it is vulnerable to oxidative damage. Hyperglycaemia is highly implicated in the progression of diabetes mellitus, and adversely affects the liver. Though, conventional hypoglycaemic drugs may be effective in reducing blood glucose, they do not appear to be effective in attenuating the progression of diabetes and its complications.Objective: This study evaluated the ameliorative effects of Anchomanes difformis on hyperglycaemia and hepatic injuries in type 2 diabetes.Methods: Type 2 diabetes was induced in male Wistar rats with a single intraperitoneal injection of streptozotocin (40 mg/kg BW) after two weeks of fructose (10%) administration. Aqueous extract of A. difformis (200 and 400 mg/kg BW) and glibenclamide (5 mg/kg BW) were administered orally for six weeks. Blood glucose concentrations were measured. Serum levels of liver dysfunction markers (ALT, AST, and ALP), total cholesterol, triglycerides, HDL- and LDL-cholesterol were investigated. Total protein, albumin, and globulin were also assessed. Antioxidant parameters: ORAC, GSH, GSSG, SOD, CAT and FRAP were evaluated in the liver while ORAC, FRAP and lipid peroxidation were determined in the serum. Histological examination of the liver tissue was carried out.Results: Treatment with aqueous extract of A. difformis significantly (p<0.05) reduced blood glucose and reversed steatosis in the diabetic-treated rats. The antioxidant status of diabetic-treated rats was significantly (p<0.05) improved. Serum levels of liver dysfunction markers were significantly (p<0.05) reduced in diabetic-treated rats.Conclusion: The findings in this study revealed that 400 mg/kgBW Anchomanes difformis was more effective than 200 mg/kg BW in ameliorating diabetes-induced hepatopathy, however, both doses of Anchomanes difformis demonstrated more antidiabetic ability than glibenclamide. Anchomanes difformis may be a novel and potential therapeutic agent in the management of diabetes and resulted hepatic injuries.

Influence of Dietary Red Palm Oil on Antioxidant Status in Male Wistar Rats

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Ademola Ayeleso ◽  
Oluwafemi Oguntibeju ◽  
Nicole Brooks
Keyword(s):  
Palm Oil ◽  
Antioxidant Status ◽  
Wistar Rats ◽  
Red Palm Oil ◽  
Male Wistar Rats

Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats

2012 ◽  
Vol 32 (11) ◽  
pp. 920-928 ◽  
Author(s):  
K. Dziendzikowska ◽  
J. Gromadzka-Ostrowska ◽  
A. Lankoff ◽  
M. Oczkowski ◽  
A. Krawczyńska ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Wistar Rats ◽  
Time Dependent ◽  
Male Wistar Rats

Effects of Prepubertal Exposure to Silver Nanoparticles on Reproductive Parameters in Adult Male Wistar Rats

2013 ◽  
Vol 76 (17) ◽  
pp. 1023-1032 ◽  
Author(s):  
Hanan Khaled Sleiman ◽  
Renata Marino Romano ◽  
Claudio Alvarenga de Oliveira ◽  
Marco Aurelio Romano
Keyword(s):  
Silver Nanoparticles ◽  
Adult Male ◽  
Wistar Rats ◽  
Reproductive Parameters ◽  
Male Wistar Rats

scholarly journals The role of poly-herbal extract in sodium chloride-induced oxidative stress and hyperlipidemia in male Wistar rats

2021 ◽  
Author(s):  
Olumide Fadahunsi ◽  
Peter Adegbola ◽  
Olayemi Adebola Akintola ◽  
Bamidele Stephen Ajilore ◽  
olubukola sinbad Olorunnisola
Keyword(s):  
Nitric Oxide ◽  
Serum Lipid ◽  
Antioxidant Status ◽  
Wistar Rats ◽  
Density Lipoprotein ◽  
High Salt ◽  
Herbal Extract ◽  
High Salt Diet ◽  
Salt Diet ◽  
Male Wistar Rats

Abstract Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designed to investigate the combined effect of some commonly employed medicinal plants on serum lipid profile and antioxidant status of aorta, kidney, and liver of high salt diet-fed animals. Thirty-five male Wistar rats were divided into 5 groups of 7 animals each. Group 1 and 2 animals were fed normal rat and 16 % high salt diet only respectively. Animals in groups 3, 4, and 5 were fed 16% high salt diet with 800, 400, and 200 mg/kg bw poly-herbal extract (PHE) respectively once for 28 consecutive days. Serum low-density lipoprotein (LDL), triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein (HDL), malondialdehyde, nitric oxide, catalase, superoxide dismutase, glutathione peroxidase, glutathione concentration, and activities were assessed in the aorta, kidney, and liver. PHE (p < 0.05) significantly reduced malondialdehyde and nitric oxide concentration and increased antioxidant enzymes and glutathione activity. Elevated serum TG, TC, LDL, and TC content in HSD-fed animals were significantly (p < 0.05) reduced to normal in PHE-treated rats while HDL was significantly elevated (p < 0.05) in a concentration-dependent manner in PHE treated animals. Feeding with PHE attenuated high salt diet imposed derangement in serum lipid profile and antioxidant status in the organs of the experimental rats.

Sign in / Sign up

Export Citation Format

Share Document