scholarly journals Reference ranges of AMH in early pregnancy: the Generation R Study, a population-based prospective cohort study

2021 ◽  
Author(s):  
Ramon Dykgraaf ◽  
Joop Laven ◽  
Sarah Timmermans ◽  
Maria Adank ◽  
Sjoerd van den Berg ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Prospective Cohort ◽  
Hospital Setting ◽  
First Trimester ◽  
Population Based ◽  
Reference Ranges ◽  
Placental Development

Objective: The objective of this study is to establish maternal reference values of AMH in a fertile multi-ethnic urban pregnant population and to evaluate the effect of gestational age. Design: The Generation R Study is an ongoing population-based prospective cohort study from early pregnancy onwards. Setting: Rotterdam, the Netherlands, out of hospital setting. Population: In 5806 women serum AMH levels were determined in early pregnancy (median 13.5 weeks; 95% range 10.5-17.2). Methods: The model-based AMH reference ranges for maternal age and gestational age were created using GAMLSS. Associations between AMH and several first trimester biomarkers were analyzed using multivariate linear regression analyses. Main outcome measures: AMH levels in early pregnancy and the association with placental biomarkers, hCG, sFLT, and PLGF. Results: A nomogram of AMH in early pregnancy was developed. Serum AMH levels showed a decline with advancing gestational age. Higher AMH levels were associated with a higher level of hCG and sFLT. This last association was predominantly mediated by hCG. AMH levels were negatively associated with PLGF levels. Conclusion: In this large study we show that AMH levels in the first trimester decrease with advancing gestational age. The association between AMH and the placental biomarkers hCG, sFLT and PLGF suggests a better placental development with a lower vascular resistance in mothers with higher AMH levels. AMH might be useful in predicting adverse pregnancy outcome due to impaired placental development. Keywords: Ovarian reserve, placental biomarker, nomogram, first trimester, human Choriogonadotrophin (hCG), soluble FMS-Like Tyrosine kinase-1 (sFLT), Placental Growth Factor (PLGF).

scholarly journals Development of reference ranges of handgrip strength among healthy adults 65+ in Northwest Russia: a prospective population-based cohort Crystal study

2017 ◽  
Vol 21 (4) ◽  
pp. 29-35 ◽  
Author(s):  
Anna V Turusheva ◽  
Elena V Frolova ◽  
Jean-Marie Degryse
Keyword(s):  
Cohort Study ◽  
Grip Strength ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Polynomial Regression ◽  
Population Based ◽  
Community Dwelling ◽  
Normative Values ◽  
Specific Reference ◽  
Reference Ranges

Objectives. This paper sought to provide normative values for grip strength among older adults 65+ across different age groups in northwest Russia. Methods. A population-based prospective cohort study of 611 community-dwelling individuals 65+. Grip strength was measured using the standard protocol applied in the Groningen Elderly Tests. The cut-off thresholds for grip strength were defined separately for men and women of different ages using a weighted polynomial regression. Results and conclusions. 1. This study presents age- and sex-specific reference values for grip strength in the 65+ Russian population derived from a prospective cohort study. 2. The grip strength values obtained in the current study were lower than those reported in other population-based studies in Europe and USA.

scholarly journals Postpartum Severe Acute Maternal Morbidity According to Gestational Age at Delivery in Twin Pregnancies: A Prospective Cohort Study

2021 ◽  
Author(s):  
Lola Loussert ◽  
Catherine Deneux-Tharaux ◽  
Aurélien Seco ◽  
Francois Goffinet ◽  
diane korb ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Gestational Age ◽  
Prospective Cohort ◽  
Maternal Morbidity ◽  
Population Based ◽  
Severe Acute Maternal Morbidity ◽  
Increased Risk ◽  
Gestational Age At Delivery ◽  
Twin Pregnancies

Objective: To assess the association between gestational age at delivery and postpartum severe acute maternal morbidity (SAMM) in twin pregnancies. Design: Population-based, national, prospective, cohort study Setting: From 02/2014 to 03/2015 in France Population: Women with twin pregnancies who gave birth after 32 weeks of gestation. We excluded women with fetal death or medical termination of either twin, with antepartum SAMM, with antepartum conditions responsible for postpartum SAMM. Methods: Gestational age at delivery was studied as the number of completed weeks of gestation. We assessed the association between gestational age at delivery and postpartum SAMM by using multivariable multilevel modified Poisson regression modelling. Main Outcome Measures: Composite criteria of postpartum severe acute maternal morbidity Results: Among the 7,713 women included, 410 (5.3%) developed postpartum SAMM, mainly (88.5%) postpartum haemorrhage. Compared with the reference category of 37 weeks, the risk of postpartum SAMM was significantly lower for all categories of earlier gestational age at delivery (from aRR=0.34, 95% CI 0.17-0.68 at 32 weeks to aRR=0.71, 95% CI 0.54-0.94 at 36 weeks), and did not differ for later categories. Conclusion: In twin pregnancies, compared with delivery at 37 weeks, delivery at earlier gestational ages is associated with a lower risk of postpartum SAMM. Continuing pregnancy beyond 37 weeks is not associated with an increased risk of postpartum SAMM. Funding: Supported by a grant from the French Ministry of Health (Programme Hospitalier de Recherche Clinique, AOM2012) and a grant from Université Toulouse III. Keywords: severe acute maternal morbidity, twin pregnancy, timing of delivery

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