scholarly journals Differential challenges in salivary gland neoplasms

2021 ◽  
pp. 2-2
Author(s):  
Nikola Zivkovic ◽  
Milos Kostic ◽  
Ana Cvetanovic ◽  
Maja Jovicic-Milentijevic ◽  
Milan Spasic ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Optical Density ◽  
Morphometric Analysis ◽  
Malignant Tumors ◽  
Basal Cell Adenoma ◽  
Proliferative Index ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Integrated Optical

Salivary gland tumors are neoplasms characterized by a high level of pleomorphism and histological overlap. One tumor may contain several cell types; therefore, it is necessary to include immunohistochemical staining, as well as morphometric analysis of tumor cells as prerequisites for an appropriate diagnosis. Our research included 120 tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, myoepithelioma, adenoid cystic carcinoma, mucoepidermoid carcinoma, salivary duct carcinoma, polymorphous low-grade carcinoma and myoepithelial carcinoma. The aim of the study was to differentiate benign and malignant tumors based on the characteristics of nuclei. The expression of Ki67 and the morphometric nuclear parameters - area, perimeter, Feret diameter, integrated optical density, circularity, and roundness, were analyzed. It was observed that the Ki67 proliferative index was statistically significantly higher in malignant tumors (P<0.001). Adenoid cystic carcinoma exhibited the highest value, whereas the lowest value was exhibited in basal cell adenoma. Morphometric analysis showed statistically significantly increased values of integrated optical density (P<0.001) and nuclear size parameters (P<0.05) in malignant tumors. The determination of the Ki67 proliferative index and morphometric analysis of the integrated optical density and area can differentiate benign from malignant tumors with high precision. The presented values suggest the obtained results as cut-off values.

scholarly journals GAMBARAN HISTOPATOLOGI TUMOR KELENJAR LIUR DI MANADO PERIODE JULI 2010 – JULI 2013

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Marcella P. J. Merung
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Large Cell Lymphoma

Abstract: Salivary glands tumor is relatively rare. In Indonesia, there’s still no complete data about the estimated incidence of salivary glands tumor. Objective:To determine the histopathology of the salivary gland tumor in Manado from July 2010 to July 2013. Methode: This was a descriptive retrospective study. Result: There were 70 patients had salivary gland tumorswith52.9% femaleand47.1% male). By age groups found that ≤16 age group for 1,4%, 17 - 30 for 28.6%, 31 – 40 for18.%), 41 – 50 for21.4%, 51 – 60 for14.3%, 61 – 70 for8.6%, ≥71 for 7.1%. By classification histopathology, Pleiomorphic adenoma for 57.2%, Whartin’s tumor for 11.4%, Oncocytoma, Mucoepidermoid carcinoma, and Adenocarcinoma each for 5.7%, Adenoid cystic carcinoma for4.3%,Cystadenoma for 3.0%, Myoepithelioma, Basal cell adenoma, Canalicular adenoma, Cystadenocarcinoma,and Large cell lymphoma malignant each for 1.4%. By the location, parotis gland for 47.1%, submandibula gland for 27.1%, minor salivary gland for 12.9% and the other location for 12.9%. Conclusion: Female is more than male, the highest incidence is in the group 17-30 years old, the most common benign tumors is pleomorphic adenoma while the most common type of malignant tumors is mucoepidermoid carcinoma and adenocarcinoma. The most frequent tumor’s location is parotid gland. Keywords: Salivary glands tumor, histopathology.   Abstrak: Tumor kelenjar liur merupakan tumor yang jarang ditemukan. Indonesia masih belum ada data lengkap mengenai insiden tumor kelenjar liur.Tujuan: Untuk mengetahui gambaran histopatologi tumor kelenjar liur di Manado periode Juli 2010 – Juli 2013. Metode:Penelitian ini bersifat deskriptif retrospektif. Hasil: Dari 70 penderita tumor kelenjar liurditemukan perempuan 52,9% dan laki-laki 47,1%. Kelompok usia ≤16 tahun sebanyak 1,4%, 17 - 30 tahun sebanyak 28,6%,31 – 40 tahun sebanyak 18,6%, 41 – 50 tahun sebanyak 21,4%, 51 – 60 tahun sebanyak 14,3%, 61 – 70 tahun sebanyak 8,6%, ≥71 tahun sebanyak 7,1%. Berdasarkan klasifikasi histopatologi jenis Pleimorphic adenoma sebanyak 57,2%, Whartin’s tumor sebanyak 11,4%, Oncocytoma,Mucoepidermoid carcinoma, dan Adenocarcinoma masing-masing sebanyak 5,7%,Adenoid cystic carcinoma sebanyak 4,3%, Cystadenoma sebanyak 3,0%, Myoepithelioma,Basal cell adenoma,Canalicular adenoma, Cystadenocarcinoma,dan Large cell lymphoma malignant masing-masing sebanyak 1,4%. Berdasarkan lokasi tumor, kelenjar parotis sebanyak 47,1%, kelenjar submandibula sebanyak 27,1%, kelenjar liur minor sebanyak 12,9% dan lokasi yang tidak jelas sebanyak 12,9%. Kesimpulan:Penderita perempuan lebih banyak dari laki-laki, insiden tertinggi pada kelompok usia17 – 30 tahun, tumor jinak paling banyak ditemukan adalah pleomorphic adenoma sedangkan tipe ganas adalah mucoepidermoid carcinoma dan adenocarcinoma. Lokasi tumor tersering adalah kelenjar parotis. Kata Kunci: Tumor kelenjar liur, histopatologi.

Congenital Hybrid Basal Cell Adenoma—Adenoid Cystic Carcinoma of the Salivary Gland

1986 ◽  
Vol 6 (2-3) ◽  
pp. 199-208 ◽  
Author(s):  
Preston R. Simpson ◽  
Joe C. Rutledge ◽  
Steven D. Schaefer ◽  
Robert C. Anderson
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Basal Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic

Basal-cell adenoma of the salivary gland: A benign adenoma that cytologically mimics adenoid cystic carcinoma

1988 ◽  
Vol 4 (4) ◽  
pp. 342-346 ◽  
Author(s):  
Michael W. Stanley ◽  
Charles A. Horwitz ◽  
Michelle J. Henry ◽  
Linda G. Burton ◽  
Torsten Lowhagen
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Basal Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Benign Adenoma

scholarly journals Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Nafise Shamloo ◽  
Alireza Ghanadan ◽  
Fahimeh Sadat Hashemian ◽  
Maedeh Ghorbanpour
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Tumors ◽  
The Body ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Cross Sectional ◽  
Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

Cystic Basal Cell Adenoma of the Parotid Gland with an Adenoid Cystic Carcinoma-like Structure

2003 ◽  
Vol 15 (2) ◽  
pp. 128-134 ◽  
Author(s):  
Masakatsu Fukuda ◽  
Masaru Miyata ◽  
Koichi Okabe ◽  
Hiroshi Kurumaya ◽  
Kouichi Nagao ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Basal Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic

scholarly journals Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Wuwei Li ◽  
Ryo Tamamura ◽  
Bo Wang ◽  
Qigui Liu ◽  
Han Liu ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Expression Pattern ◽  
Malignant Tumors ◽  
Expression Patterns ◽  
Myoepithelial Cells ◽  
Positive Staining ◽  
Ki 67 ◽  
Adenoid Cystic ◽  
Significant Difference

Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs.

Basal cell adenocarcinoma of the parotid gland

1990 ◽  
Vol 104 (2) ◽  
pp. 150-151 ◽  
Author(s):  
G. E. Murty ◽  
A. R. Welch ◽  
J. V. Soames
Keyword(s):  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Basal Cell ◽  
Surgical Excision ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Basal Cell Adenocarcinoma ◽  
Adenoid Cystic

AbstractA case of basal cell adenocarcinoma of the parotid gland is reported. Histologically it is to be distinguished from basal cell adenoma and adenoid cystic carcinoma. Clinically the presentation may appear benign. Surgical excision is the treatment of choice. The prognosis is uncertain because of lack of follow-up data.

scholarly journals A Rare Variety of Adenoid Cystic Carcinoma involving Submandibular Salivary Gland

2015 ◽  
Vol 23 (2) ◽  
pp. 77-80
Author(s):  
Sanjoy Kumar Ghosh ◽  
Saikat Samaddar ◽  
Swagatam Banerjee ◽  
Diptanshu Mukherjee
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Submandibular Gland ◽  
Histopathological Examination ◽  
Salivary Gland Neoplasm ◽  
Submandibular Salivary Gland ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Benign Adenoma ◽  
Solid Variety

IntroductionAdenoid cystic carcinoma, an uncommon malignant salivary gland neoplasm, is known for its long clinical course, indolent growth, neural invasion, local recurrence and late distant metastasis. Three distinct histological patterns have been identified, amongst which, solid pattern is the rarest one having the worst prognosis. Materials And MethodsA case of sixty year old male patient presented with a swelling in the left side of the neck, below the jaw gradually enlarging during the last three years. FNAC from the neck swelling was suggestive of benign adenoma of the salivary gland, possibly basal cell adenoma or pleomorphic adenoma. Submandibular gland was excised. Histopathological examination confirmed the solid pattern of adenoid cystic carcinoma, which is the rarest among the three distinct histological subtypes of the malignancy. DiscussionAdenoid cystic carcinoma is well known for its perineural spread. In cases of submandibular gland adenoid cystic carcinoma, surgical wide excision is very much possible and in T1 or T2 cases post-operative radiotherapy may not be needed. In our case, post operative radiotherapy was given for best local control, as the tumour showed histopathlogical solid variety, grade III pattern, which is known to have the worst prognosis.

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