scholarly journals Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Wuwei Li ◽  
Ryo Tamamura ◽  
Bo Wang ◽  
Qigui Liu ◽  
Han Liu ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Expression Pattern ◽  
Malignant Tumors ◽  
Expression Patterns ◽  
Myoepithelial Cells ◽  
Positive Staining ◽  
Ki 67 ◽  
Adenoid Cystic ◽  
Significant Difference

Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs.

scholarly journals Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Nafise Shamloo ◽  
Alireza Ghanadan ◽  
Fahimeh Sadat Hashemian ◽  
Maedeh Ghorbanpour
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Tumors ◽  
The Body ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Cross Sectional ◽  
Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

scholarly journals Analysis of Ki-67 expression as clinicopathological parameters in predicting the prognosis of adenoid cystic carcinoma

2017 ◽  
Vol 50 (4) ◽  
pp. 205
Author(s):  
Silvi Kintawati ◽  
Murnisari Darjan ◽  
Winny Yohana
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Cellular Proliferation ◽  
Salivary Gland Tumor ◽  
Clinicopathological Parameters ◽  
Clinical Parameters ◽  
Ki 67 ◽  
Term Survival ◽  
Adenoid Cystic ◽  
Histopathological Grading

Background: Adenoid cystic carcinoma is a malignant salivary gland tumor located in the head and neck region. Although complete surgical resection and complementary radiotherapy have been shown to improve long-term survival rates, the prognosis of adenoid cystic carcinoma remains poor. Ki-67 expression is considered a marker for the cellular proliferation rate, the detection of its expression usually being related to the aggressiveness and unfavorable prognosis of adenoid cystic carcinoma in the salivary gland. Purpose: This study was conducted to quantify the expression of Ki-67 in adenoid cystic carcinoma and to correlate the result with clinical parameters and histopathological grading in determining the prognosis. Methods: Twenty three cases of salivary gland adenoid cystic carcinoma were identified at the Department of Anatomical Pathology, Dr. Hasan Sadikin Hospital between 2013 and 2015. Clinical data such as age, gender, location of tumor and histopathological grading was also collected. The expression of Ki-67 was assessed by immunohistochemical means to determine the correlation of Ki-67 with clinical parameters and histopathological grading. Results: There were no significant differences between the expression of Ki-67 and clinical parameters, although a very strong correlation existed between the expression of Ki-67 and histopathological grading (p < 0.01). Conclusion: There were no correlation between the expression of Ki-67 and clinical parameters, although a correlation existed between the expression of Ki-67 and histopatological grading in salivary gland adenoid cystic carcinoma. Thus, clinical parameters were unusable in determining the prognosis of adenoid cystic carcinoma, although Ki-67 expression could be used for this purpose.

scholarly journals Differential challenges in salivary gland neoplasms

2021 ◽  
pp. 2-2
Author(s):  
Nikola Zivkovic ◽  
Milos Kostic ◽  
Ana Cvetanovic ◽  
Maja Jovicic-Milentijevic ◽  
Milan Spasic ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Optical Density ◽  
Morphometric Analysis ◽  
Malignant Tumors ◽  
Basal Cell Adenoma ◽  
Proliferative Index ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Integrated Optical

Salivary gland tumors are neoplasms characterized by a high level of pleomorphism and histological overlap. One tumor may contain several cell types; therefore, it is necessary to include immunohistochemical staining, as well as morphometric analysis of tumor cells as prerequisites for an appropriate diagnosis. Our research included 120 tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, myoepithelioma, adenoid cystic carcinoma, mucoepidermoid carcinoma, salivary duct carcinoma, polymorphous low-grade carcinoma and myoepithelial carcinoma. The aim of the study was to differentiate benign and malignant tumors based on the characteristics of nuclei. The expression of Ki67 and the morphometric nuclear parameters - area, perimeter, Feret diameter, integrated optical density, circularity, and roundness, were analyzed. It was observed that the Ki67 proliferative index was statistically significantly higher in malignant tumors (P<0.001). Adenoid cystic carcinoma exhibited the highest value, whereas the lowest value was exhibited in basal cell adenoma. Morphometric analysis showed statistically significantly increased values of integrated optical density (P<0.001) and nuclear size parameters (P<0.05) in malignant tumors. The determination of the Ki67 proliferative index and morphometric analysis of the integrated optical density and area can differentiate benign from malignant tumors with high precision. The presented values suggest the obtained results as cut-off values.

Comparison of mortality trends in patients with non-salivary gland and salivary gland adenoid cystic carcinoma in the United States population.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17584-e17584
Author(s):  
Girindra Ghanshyam Raval ◽  
Germame Hailegiorgis Ajebo ◽  
Locke Johnson Bryan ◽  
Achuta Kumar Guddati
Keyword(s):  
African American ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Neck Region ◽  
Mortality Trends ◽  
Adenoid Cystic ◽  
Black Patients ◽  
Significant Difference ◽  
American Black ◽  
White Patients

e17584 Background: Adenoid cystic carcinoma is the most common histological subtype of malignancy seen in major and minor salivary glands. Although indolent they tend to recur and progress. Adenoid cystic carcinoma also arises from other structures such as lacrimal glands and trachea. This study compares the incidence-based mortality between patients who have salivary and no-salivary origin adenoid cystic carcinomas of the head and neck region over the period of 2000 to 2014. Methods: A nation-wide analysis was conducted utilizing the Surveillance, Epidemiology, and End Results (SEER) Database from the years 2000 to 2014. Incidence-based mortality for all stages of adenoid cystic carcinoma was queried and the results were grouped by race (Caucasian/White, African American/Black, American Indian/Alaskan native and Asian/Pacific Islander) and gender. All stages were included in the analysis. T-test was used to determine statistically significance difference between various subgroups. Linearized trend lines were used to visualize the mortality trends of all sub groups. Results: Incidence-based mortality for salivary gland adenoid cystic carcinomas in African American/Black patients is comparable to Caucasian/White patients despite a higher incidence in Caucasian/White patients (no statistically significant difference was noted). Also, the incidence-based mortality for non-salivary gland adenoid cystic carcinomas of the head and neck region in African American/Black patients was similar to Caucasian/White patients. Essentially no racial difference in mortality was noted between salivary and non-salivary gland tumors. Comparison of mortality between genders in both races in salivary and non-salivary gland tumors also did not show any statistically significant difference. Conclusions: This study showed that adenoid cystic carcinoma of non-salivary gland origin have the same mortality trends as that from salivary gland origin in both Caucasian/White and American/Black patients and in both genders. Given such uniformity, genetic and environmental factors may not play significant role in the progression and outcomes of this disease. Hence, adenoid cystic carcinoma may be treated with similar therapeutic approaches regardless of the origin, gender and race of the patient.

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