scholarly journals Influence of cyanide on some antioxidant enzymes of freshwater fish, Cirrhinus mrigala (Hamilton)

2013 ◽  
Vol 58 (3) ◽  
pp. 177-184
Author(s):  
Shwetha Alavandi ◽  
Basaling Hosetti

Sublethal toxicity of cyanide to freshwater fish, Cirrhinus mrigala was evaluated to determine its effect on the activities of some antioxidative enzymes. Changes in succinate dehydrogenase (SDH), lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6-PDH) were observed in tissues of the tested animal. Cyanide significantly decreased the activity of SDH, and G6-PDH in the liver, gill and brain tissues of the fish. The elevation of LDH indicated metabolic disorders and a clear response against energy depletion. Changes in the dehydrogenase activity in cyanide treated fish tissues may be due to fluctuations in oxidative metabolism. It is concluded that the cyanide intoxication exerted a profound impact on the enzymatic activity of the fish, as observed in the hitherto study.

2012 ◽  
Vol 64 (1) ◽  
pp. 257-263 ◽  
Author(s):  
Shwetha Dube ◽  
B.B. Hosetti

The present study was conducted to evaluate the effects of zinc cyanide (Zn(CN)2) on the ATPase (Na+-K+-, Mg2+, Ca2+) activity of the freshwater fish Cirrhinus mrigala (Ham). Fish were exposed to two sublethal concentrations (0.114 and 0.068 mg/L) and the effects were studied in the liver, muscle and gill tissues at the end of 5, 10 and 15 days of exposure. Cyanide intoxication resulted in marked changes in ATPases, represented by a significant decrease in the activities. Maximum inhibition was observed at higher concentration. The order of inhibition in the activity was Na+-K+-> Ca2+ > Mg2+ ATPase. These results imply an immediate adaptive response to the stress, demonstrating alterations in ATPase activities in the tissues of cyanide-treated fish. The present study clearly proposes that ATPases can be used as biomarkers of exposure of aquatic organisms to cyanide intoxication.


2018 ◽  
Vol 6 (1) ◽  
pp. 49
Author(s):  
S. C. Jayamanne ◽  
G. G. N. Thushari ◽  
N. P. P. Liyanage ◽  
I. G. S. N. K. Abeyrathne

Author(s):  
Philip Wiffen ◽  
Marc Mitchell ◽  
Melanie Snelling ◽  
Nicola Stoner

This chapter outlines information relevant to pharmacists and other healthcare professionals on patient management issues related to special populations. It covers management of patients with liver impairment, including drug use, drug dosing, and hepatorenal syndrome. Drug use and dosing in renal impairment is discussed and the various methods of assessing or calculating glomerular filtration rate are reviewed. The use of drugs in pregnancy and breastfeeding is discussed with guidance given on assessing the risks versus benefits of drug use in these situations. Drugs and dietary considerations (including cultural considerations, food allergy and intolerance, and metabolic disorders), glucose-6-phosphate dehydrogenase deficiency and porphyria are discussed.


2015 ◽  
Vol 7 (2) ◽  
pp. 136
Author(s):  
M. Lekeshmanaswamy ◽  
K. Anusiya devi ◽  
C.A. Vasuki

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yuri P. Tsentalovich ◽  
Ekaterina A. Zelentsova ◽  
Lyudmila V. Yanshole ◽  
Vadim V. Yanshole ◽  
Iliya M. Odud

Abstract Quantitative metabolomic analysis was performed for eleven tissues of freshwater fish pike-perch (Sander lucioperca), including gill, heart, liver, kidney, spleen, muscle, brain, milt, lens, aqueous (AH) and vitreous (VH) humors with the use of NMR spectroscopy. The absolute values of concentrations were determined for more than 65 most abundant metabolites in every tissue. It was found that from the metabolomic viewpoint, kidney and gill are the most similar tissues, while the metabolomic compositions of ocular tissues—lens, AH, and VH significantly differ from that of other tissues. The combinations of intracellular osmolytes and antioxidants are specific for every tissue. In particular, the concentration of antioxidant ovothiol A in the lens is much higher than in any other tissue, while the brain enjoys the elevated level of ascorbate. The most abundant osmolyte in the fish spleen, muscle, and heart is taurine, and in the brain, gill, and lens—myo-inositol. Other important osmolytes specific for particular tissues are N-acetyl-histidine, N-acetyl-aspartate, betaine, threonine-phosphoethanolamine, and serine-phosphoethanolamine. The quantitative data obtained in the present work can be used as the baseline metabolite concentrations in the fish tissues to evaluate the influence of seasonal, ecological and other factors on the fish metabolism.


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