scholarly journals The analysis of acid-base balance in haemodialyzed patients and the effect of etiology of chronic renal failure on acid-base parameter values

2004 ◽  
Vol 23 (2) ◽  
pp. 175-178
Author(s):  
Emina Colak ◽  
Sanja Stankovic ◽  
Nada Majkic-Singh ◽  
Milan Radovic
Keyword(s):  
Renal Failure ◽  
Metabolic Acidosis ◽  
Chronic Renal Failure ◽  
Underlying Disease ◽  
Tubular Secretion ◽  
Acid Base Balance ◽  
Acid Base ◽  
Significant Difference ◽  
Before And After ◽  
Base Balance

Due to reduced scope of renal function in chronic renal failure (CRF) it is not rare that it comes to marked metabolic acidosis and pathologic catabolism associated with hypoxia. The cause of metabolic acidosis is deminished tubular secretion of ammonia, due to reduced synthesis, stipulated by lower number of renal canaliculi. Acid-base balance was analyzed in 74 patients suffering from CRF who were on haemodialysis program. Heparinised blood was taken from these patients before and after haemodialysis in which the following parameters were measured: pH, pCO2, pO2, HCO-3 ?, TCO2. The aim of this study was the monitoring of patients' acid-base status before and after haemodilalysis in order to evaluate the degree of stabilization of acid-base balance after haemodilalysis and also to define the correlation between the etiology of CRF and the degree of acid-base balance disorder. In relation to underlying disease resulting in CRF, the patients were divided into five groups: I-tubular interstitial nephrosis (TIN), II-polycystic kidney disease (ADPKD), III-glomerulonephritis (GN), IVhypertension and nephroangio-sclerosis (HTA-Nascl) and V-consisting of patients whose underlying disease was not diagnosed (ERSD). The obtained values of pH, HCO2 and TCO2 after haemodialysis (pH = 7.428 ? 0.06; HCO-3 ?= 25.4 ? 3.44 mmol/L; TCO2 = 26.57 ? 3.56 mmol/L), were significantly increased (p<0.001), in relation to values before haemodialysis (pH = 7.350 ? 0.05; HCO-3 ?= 20.88 ? 2.92 mmol/L; TCO2 = 22.03 ? 3.00 mmol/L). There was no statistically significant difference in values of measured parameters (p>0.05) in relation to underlying disease either before or after haemodialysis both in males and females.

scholarly journals Effect of an acute oral protein load on renal acidification in healthy humans and in patients with chronic renal failure.

1997 ◽  
Vol 8 (5) ◽  
pp. 784-792
Author(s):  
N G de Santo ◽  
G Capasso ◽  
G Malnic ◽  
P Anastasio ◽  
L Spitali ◽  
...  
Keyword(s):  
Renal Failure ◽  
Metabolic Acidosis ◽  
Chronic Renal Failure ◽  
Urinary Excretion ◽  
Healthy Subjects ◽  
Tubular Reabsorption ◽  
Renal Tubules ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

The effect of a meat load on the renal handling of acid-base balance was studied in ten healthy subjects (GFR by inulin clearance = 98.5 +/- 8.14 ml.min-1.1.73 m-2) and in ten patients affected by chronic renal failure (CRF) (GFR = 39.9 +/- 5.3 ml.min-1.1.73 m-2). After the meat load (2 g.kg-1 body weight of cooked unsalted red meat), GFR increased by 26.9% (peak value) over baseline in healthy subjects and by 32% in CRF patients. The acid-base status of the healthy subjects was in the normal range, whereas the CRF patients disclosed a slight metabolic acidosis. After a meat load, there was, in the healthy subjects, an increase in the filtered load of bicarbonate coupled to an enhanced tubular reabsorption and urinary excretion. The time course between bicarbonate load and urinary excretion was coincident. In CRF patients, the increase of bicarbonate tubular load after the meal was associated with an increase in tubular reabsorption but not in urinary excretion of this anion. The relationship between bicarbonate load and reabsorption was linear in both groups up to the highest filtered loads. Baseline titratable acidity (TA) and ammonium (NH4+) excretion (expressed per ml GFR) were increased in CRF patients as compared with control subjects, but no changes were found after the meat load in both groups in these experimental conditions. The data indicate that the renal tubules contribute to the maintenance of acid-base balance both in healthy subjects and in CRF patients by reabsorbing most of the additional bicarbonate load. The transient, but significant, increase in bicarbonate excretion observed in healthy subjects could be related to the increased tubular load of bicarbonate. In CRF patients, tubular bicarbonate reabsorption was more complete, possibly because of the stimulation of H+ secretion by the mild metabolic acidosis. TA and NH4+ did not participate in tubular compensation of the increased buffer load.

The effect of atrial natriuretic peptide on acid-base balance in rats with chronic renal failure

Life Sciences ◽  
1988 ◽  
Vol 42 (25) ◽  
pp. 2577-2585
Author(s):  
Miho Kusaka ◽  
Keiichiro Atarashi ◽  
Atsushi Numabe ◽  
Yuzaburo Baba ◽  
Kaori Shinozaki ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Atrial Natriuretic

Perspectives in Acid-Base Balance in Advanced Chronic Renal Failure

2015 ◽  
pp. 105-117 ◽  
Author(s):  
G. M. Berlyne ◽  
A. J. Adler ◽  
R. H. Barth ◽  
D. Burke ◽  
C. E. Palant
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

scholarly journals ASSOCIATION OF ACID-BASE PARAMETERS WITH LACTATE LEVEL IN CRITICALLY ILL PATIENTS WITH METABOLIC ACIDOSIS

2018 ◽  
Vol 24 (2) ◽  
pp. 141
Author(s):  
Donaliazarti Donaliazarti ◽  
Rismawati Yaswir ◽  
Hanifah Maani ◽  
Efrida Efrida
Keyword(s):  
Metabolic Acidosis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Lactate Level ◽  
Linear Regression Analysis ◽  
P Value ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Parameters ◽  
Base Balance

Metabolic acidosis is prevalent among critically ill patients and the common cause of metabolic acidosis in ICU is lactic acidosis. However, not all ICUs can provide lactate measurement. The traditional method that uses Henderson-Hasselbach equation (completed with BE and AG) and alternative method consisting of Stewart and its modification (BDEgap and SIG), are acid-base balance parameters commonly used by clinicians to determine metabolic acidosis in critically ill patients. The objective of this study was to discover the association between acid-base parameters (BE, AGobserved, AGcalculated, SIG, BDEgap) with lactate level in critically ill patients with metabolic acidosis. This was an analytical study with a cross-sectional design. Eighty-four critically ill patients hospitalized in the ICU department Dr. M. Djamil Padang Hospital were recruited in this study from January to September 2016. Blood gas analysis and lactate measurement were performed by potentiometric and amperometric method while electrolytes and albumin measurement were done by ISE and colorimetric method (BCG). Linear regression analysis was used to evaluate the association between acid-base parameters with lactate level based on p-value less than 0.05. Fourty five (54%) were females and thirty-nine (46%) were males with participant’s ages ranged from 18 to 81 years old. Postoperative was the most reason for ICU admission (88%). Linear regression analysis showed that p-value for BE, AGobserved, AGcalculated, SIG and BDEgap were 119; 0.967; 0.001; 0.001; 0.689, respectively. Acid-base balance parameters which were mostly associated with lactate level in critically ill patients with metabolic acidosis were AGcalculated and SIG. 

scholarly journals Effect of Simulated Matches on Post-Exercise Biochemical Parameters in Women’s Indoor and Beach Handball

2020 ◽  
Vol 17 (14) ◽  
pp. 5046
Author(s):  
Joanna Kamińska ◽  
Tomasz Podgórski ◽  
Jakub Kryściak ◽  
Maciej Pawlak
Keyword(s):  
Blood Parameters ◽  
Ion Concentration ◽  
Electrolyte Balance ◽  
Acid Base Balance ◽  
Acid Base ◽  
Urine Ph ◽  
Physically Active ◽  
Post Exercise ◽  
Before And After ◽  
Base Balance

This study assesses the status of hydration and the acid-base balance in female handball players in the Polish Second League before and after simulated matches in both indoor (hall) and beach (outdoor) conditions. The values of biochemical indicators useful for describing water-electrolyte management, such as osmolality, hematocrit, aldosterone, sodium, potassium, calcium, chloride and magnesium, were determined in the players’ fingertip capillary blood. Furthermore, the blood parameters of the acid-base balance were analysed, including pH, standard base excess, lactate and bicarbonate ion concentration. Additionally, the pH and specific gravity of the players’ urine were determined. The level of significance was set at p < 0.05. It was found that both indoor and beach simulated matches caused post-exercise changes in the biochemical profiles of the players’ blood and urine in terms of water-electrolyte and acid-base balance. Interestingly, the location of a simulated match (indoors vs. beach) had a statistically significant effect on only two of the parameters measured post-exercise: concentration of calcium ions (lower indoors) and urine pH (lower on the beach). A single simulated game, regardless of its location, directly affected the acid-base balance and, to a smaller extent, the water-electrolyte balance, depending mostly on the time spent physically active during the match.

Effect of systemic acid-base balance on ileal secretion

1987 ◽  
Vol 253 (3) ◽  
pp. G330-G335
Author(s):  
D. S. Goldfarb ◽  
P. M. Ingrassia ◽  
A. N. Charney
Keyword(s):  
Metabolic Acidosis ◽  
Cholera Toxin ◽  
Metabolic Disorders ◽  
Respiratory Acidosis ◽  
Secretory Process ◽  
Sprague Dawley ◽  
Acid Base Balance ◽  
Acid Base ◽  
Ph Change ◽  
Base Balance

We previously reported that systemic pH and HCO3 concentration affect ileal water and electrolyte absorption. To determine whether these effects could influence an ongoing secretory process, we measured transport in ileal loops exposed to either saline or 50-75 micrograms cholera toxin in mechanically ventilated Sprague-Dawley rats anesthetized with pentobarbital sodium. The effects of acute respiratory and metabolic acidosis and alkalosis were then examined. Decreases in systemic pH during respiratory acidosis caused equivalent increases in net water (54 +/- 8 microliters . cm-1 . h-1) and Na absorption (7 +/- 1 mu eq . cm- . h-1) and smaller increases in Cl absorption in cholera toxin compared with saline loops. These increases reversed the net secretion of these ions observed during alkalemia in the cholera toxin loops to net absorption. Metabolic acidosis and alkalosis and respiratory compensation of systemic pH of these metabolic disorders also altered cholera toxin-induced secretion in a direction consistent with the pH change. The increase in net HCO3 secretion caused by cholera toxin was unaffected by the respiratory disorders and did not vary with the HCO3 concentration in the metabolic disorders. These findings suggest that the systemic acid-base disorders that characterize intestinal secretory states may themselves alter intestinal absorptive function and fluid losses.

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