scholarly journals Identification of anti-HLA-A1 antibodies in a multi-transfused patient: Case report

2004 ◽  
Vol 57 (1-2) ◽  
pp. 77-80
Author(s):  
Svetlana Vojvodic ◽  
Stevan Popovic ◽  
Ivana Urosevic
Keyword(s):  
Single Dose ◽  
Case Report ◽  
Hla Class I ◽  
Blood Transfusions ◽  
Blood Products ◽  
Platelet Concentrates ◽  
Patient Case ◽  
Hla Antibodies ◽  
Lymphocytotoxic Antibodies ◽  
Microlymphocytotoxicity Test

Introduction HLA antibodies develop as a result of alloimmunization to HLA class I and II antigens. Their appearance is associated with frequent blood transfusions, allogeneic tissue and organ transplantation, pregnancy and immunization. It is established that after usage of single dose HLA nonmatched leukocytes, circulating lymphocytotoxic antibodies appear in serum of recipients, 10 to 12 days after alloimmunization. Case report This article describes a case report of a multi-transfused patient, with identified HLA-A1 antibodies established by using microlymphocytotoxicity test and two different panels of HLA typed lymphocytes. The case report shows occurrence of febrile posttransfusion nonhemolytic reaction (FNHTR) in our patient after application of 410 ml resuspended erythrocytes. After transfusiologists recommendations for detecting lymphocytotoxic antibodies in patient's serum, we determined a specificity of monospecific antibody which caused posttrasnfusion FNHTR. Discussion and conclusion FNHTR may be caused by antileukocyte antibodies or immunoinflammatory cytokines. It is more frequent in patients receiving platelet concentrates (15-30%) than those receiving red blood cell products (1%). This case report shows that FNHTR was caused by HLA-A1 antibody in a patient who received 111 various blood products.

scholarly journals Delayed Hemolytic Transfusion Reaction - A Case Report

2012 ◽  
Vol 4 (2) ◽  
pp. 15-19
Author(s):  
Rajay A. D. Kamath ◽  
Kiran V. Neswi ◽  
Shiva Bharani K.S.N. ◽  
M.A. Giri Sankar
Keyword(s):  
Case Report ◽  
Blood Transfusion ◽  
Blood Cells ◽  
Blood Transfusions ◽  
Transfusion Reaction ◽  
Blood Products ◽  
Hemolytic Transfusion Reaction ◽  
Delayed Hemolytic Transfusion Reaction ◽  
Cross Matching ◽  
Hematological Tests

Abstract Blood transfusion is the process of receiving blood products into one's circulation intravenously. Transfusions are used in a variety of medical conditions to replace lost components of the blood. Transfusions of blood products are associated with several complications, many of which can be grouped as immunological or infection. Acute hemolytic reactions occur with transfusion of red blood cells and are due to destruction of donor erythrocytes by preformed recipient antibodies. Most often this occurs due to clerical” errors or improper typing and cross matching. Delayed hemolytic reactions occur more frequently and are due to the same mechanism as in acute hemolytic reactions. However, the consequences are generally mild and a great proportion of patients may not have symptoms. However, evidence of hemolysis and falling hemoglobin levels may still occur. Treatment is generally not needed, but due to the presence of recipient antibodies, future compatibility may be affected. Hereby we share our experience of such a case of delayed hemolytic transfusion reaction and discussing the various measures to be taken during any such incidence and the biochemical and hematological tests to confirm the diagnosis.

Multiple Skull Base Meningiomata in a Transgender Patient: Case Report and Literature Review

2019 ◽  
Author(s):  
Andrew Alalade ◽  
Christopher Millward ◽  
Piyali Pal ◽  
Catherine Gilkes
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Skull Base ◽  
Patient Case ◽  
Transgender Patient

Auto immune hypoglycemia in individuals with type 1 diabetes, from a patient case report

2019 ◽  
Author(s):  
Rolly Junior Louzolo-Kimbembe ◽  
Ghizlane El Mghari ◽  
Nawal El Ansari
Keyword(s):  
Type 1 Diabetes ◽  
Case Report ◽  
Patient Case

Rare NRAS mutation causing Noonan syndrome type 6 in a Saudi patient: case report

2021 ◽  
pp. 413-415
Author(s):  
Sara Alomar ◽  
Anfal Alsultan ◽  
Halah AlMuhaidib ◽  
Sarah Aldhahri ◽  
Dalal Bubshait
Keyword(s):  
Case Report ◽  
Noonan Syndrome ◽  
Syndrome Type ◽  
Patient Case ◽  
Nras Mutation

Acute Dystonia after a Single Dose of Intravenous Metoclopramide during Elective Cesarean Section: A Case Report.

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Danielle Levin
Keyword(s):  
Single Dose ◽  
Case Report ◽  
Cesarean Section ◽  
Epidural Anesthesia ◽  
Elective Cesarean Section ◽  
Single Administration ◽  
Dystonic Reaction ◽  
Elective Cesarean ◽  
Combined Spinal Epidural Anesthesia ◽  
Spinal Epidural

We would like to present the first report of severe acute dystonic reaction after a single administration of metoclopramide during cesarean section under combined spinal-epidural anesthesia.  During elective cesarean section, a 30-year-old female vomited four times and was treated with 10mg intravenous metoclopramide and 8mg intravenous ondansetron.  Nausea subsided with the antiemetic treatment, but two minutes later, patient had rapid eye blinking, uncontrollable head movement, and became unresponsive.  Bolus of 50mg intravenous diphenhydramine resolved the acute dystonic symptoms within seconds.  Patient was again oriented times three, with no recollection of symptoms, and remained symptom free for the rest of admission. 

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