scholarly journals Analysis of correlation and regression between particle ionizing radiation parameters and the stability characteristics of irradiated monocrystalline Si film

2014 ◽  
Vol 29 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Uros Jaksic ◽  
Nebojsa Arsic ◽  
Irfan Fetahovic ◽  
Koviljka Stankovic

This paper deals with the analysis of correlation and regression between the parameters of particle ionizing radiation and the stability characteristics of the irradiated monocrystalline silicon film. Based on the presented theoretical model of correlation and linear regression between two random variables, numeric and real experiments were performed. In the numeric experiment, a simulation of the effect of alpha radiation on a thin layer of monocrystalline silicon was performed by observing a number of vacancies along the film depth resulting from a single incident alpha particle. In the real experiment, the irradiation of a thin silicon film by alpha particles from a radioactive Am-241 alpha emitter was performed. The observed values of radiation effect on the Si film were specific resistance and the concentration of free charge carriers. The results showed a fine concordance between numeric and real experiments. Correlation verification of the observed values was presented by linear regression functions.


2021 ◽  
Vol 2 (4) ◽  
pp. 196-207
Author(s):  
Emanuel Sporer ◽  
Christian B. M. Poulie ◽  
Sture Lindegren ◽  
Emma Aneheim ◽  
Holger Jensen ◽  
...  

Targeted α-therapy (TAT) can eradicate tumor metastases while limiting overall toxicity. One of the most promising α-particle emitters is astatine-211 (211At). However, 211At-carbon bonds are notoriously unstable in vivo and no chelators are available. This hampers its adoption in TAT. In this study, the stability of 211At on the surface of gold nanoparticles (AuNPs) was investigated. The employed AuNPs had sizes in the 25–50 nm range. Radiolabeling by non-specific surface-adsorption in >99% radiochemical yield was achieved by mixing 211At and AuNPs both before and after polyethylene glycol (PEG) coating. The resulting 211At-AuNPs were first challenged by harsh oxidation with sodium hypochlorite, removing roughly 50% of the attached 211At. Second, incubation in mouse serum followed by a customized stability test, showed a stability of >95% after 4 h in serum. This high stability was further confirmed in an in vivo study, with comparison to a control group of free 211At. The AuNP-associated 211At showed low uptake in stomach and thyroid, which are hallmark organs of uptake of free 211At, combined with long circulation and high liver and spleen uptake, consistent with nanoparticle biodistribution. These results support that gold surface-adsorbed 211At has high biological stability and is a potentially useful delivery system in TAT.



2010 ◽  
Vol 35 (8) ◽  
pp. 1139 ◽  
Author(s):  
Oren Guilatt ◽  
Boris Apter ◽  
Uzi Efron


Author(s):  
Sophie Puget ◽  
Germain Bossu ◽  
Arnaud Regnier ◽  
Rossella Ranica ◽  
Alexandre Villaret ◽  
...  


2004 ◽  
Vol 5 (3) ◽  
pp. 136-141 ◽  
Author(s):  
Christian Dilcher ◽  
Rosanna Chan ◽  
David Hellinga ◽  
Rufus Seabron ◽  
Rajbabu Pakala ◽  
...  


2016 ◽  
Vol 42 (1) ◽  
pp. 151 ◽  
Author(s):  
Lorelle N. Pye ◽  
Massimo L. Villinger ◽  
Soroush Shabahang ◽  
Walker D. Larson ◽  
Lane Martin ◽  
...  






Author(s):  
G. Ghibaudo ◽  
M. Mouis ◽  
L. Pham-Nguyen ◽  
K. Bennamane ◽  
I. Pappas ◽  
...  


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