scholarly journals Sentinel node biopsy for skin melanoma

2009 ◽  
Vol 66 (8) ◽  
pp. 657-662 ◽  
Author(s):  
Predrag Kovacevic ◽  
Milan Visnjic ◽  
Marina Vlajkovic ◽  
Tatjana Kovacevic ◽  
Aleksandar Visnjic
Keyword(s):  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
False Negative ◽  
Primary Melanoma ◽  
Patient Characteristics ◽  
Breslow Thickness ◽  
Blue Dye ◽  
Skin Melanoma ◽  
Node Biopsy

Background/Aim. Skin melanoma is one of the most malignant diseases with increasing incidence rate. Sentinel node biopsy (SNB) is very important for early detection of metastatic spread. The aim of the study was to analyze the first 40 patients with skin melanoma of 1 to 4 mm Breslow thickness when SNB was indicated. Methods. The patient characteristics, localization of the primary melanoma as well as histology grade were analyzed. SNB with intraoperative radiocolloid and methylene blue dye detection was performed. Results. Complication rate after SNB was analyzed and seroma was found in 5% of the patients. The therapeutic node dissection was performed in 10 patients with positive sentinel biopsy. The follow-up lasted two years. In five patients the false negative SNB was defined after the mean time of 11 months and the therapeutic dissection was performed. Conclusion. SNB in melanoma patients is a useful diagnostic procedure. It is advised for melanoma of 1 to 4 mm Breslow thickness.

Sentinel node biopsy in melanoma patients: The role of day surgery and local anaesthetic approach for quality-of-life and effective cost reduction.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19002-e19002
Author(s):  
Fabio Ricci ◽  
Erminio Saralli ◽  
Loreto Giovanni Capuano ◽  
Maurizio Dorkin ◽  
Mario Valleriani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Cost Reduction ◽  
Primary Melanoma ◽  
Day Surgery ◽  
Blue Dye ◽  
Node Biopsy ◽  
Melanoma Patients

e19002 Background: Sentinel node biopsy (SNB) is used in the management of melanoma patients without nodal metastases. Methods: From January 1, 1998 to December 31, 2011 we performed 182 SNBs at St. M. Goretti Hospital. Patients presented a primary melanoma, Breslow thickness equal to or higher than 1 mm, lower than 1 mm with regression and/or ulceration, and/or IV-V Clark level, and/or mitotic rate ≥ 1/mm2, according to the 7th edition melanoma staging system. All patients underwent pre-operative lymphoscintigraphy with intradermal injection of 50-70 MBq 99 mTc colloidal albumina particles, 50-80 nm size range, in 0.1-0.2 ml saline solution. We never used blue dye. All patients underwent surgical treatment 4-12 h. later. We performed SNB in day-surgery (DS) under local anaesthesia (LA). Surgery incision was 3-4 cm. This study was approved by an ethics committee, discussed with all patients and informed consent was obtained. Purpose of the study is to investigate the validity of this approach for quality of life and cost reduction. Results: 165 patients underwent SNB, 64 (38.7%) in the inguinal region, 83 (50.3%) in axilla, 1 (0.6%) in the popliteal region, 4 (2.4%) patients showed inguinal bilateral sentinel lymph-node (SLN), 6 (3.6%) axillary bilateral SLN, 4 (2.4%) axillary and 3 (1.8%) inguinal double SLN. The SLN identification rate was 100%. After surgery we distributed a questionnaire to the patients about the acceptability of this approach. In 32 patients SLN was positive. In these patients we performed radical lymphoadenectomy, 12 (37.5%) inguinal and 20 (62.5%) axillary. Conclusions: The results achieved are extremely accurate. This procedure is safe, well accepted by patients (98%), reported better quality of life. The oncological results are absolutely reliable. As regards hospital logistics, operations in DS and LA can be easily managed, leading to a significant cost reduction, 42.15% less expensive than the same operation performed under general anaesthesia.

Sentinel Node Biopsy and Selective Dissection for Melanoma Nodal Metastases

1998 ◽  
Vol 84 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Filiberto Belli ◽  
Leonardo Lenisa ◽  
Claudio Clemente ◽  
Gabrina Tragni ◽  
Luigi Mascheroni ◽  
...  
Keyword(s):  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Frozen Section ◽  
Primary Melanoma ◽  
Distant Metastases ◽  
Blue Dye ◽  
Nodal Metastases ◽  
Nodal Basin ◽  
Node Biopsy ◽  
Occult Disease

Background Early detection of nodal metastases still represents an important goal in the management of melanoma patients. A sentinel node is defined as the first colored node in the regional lymphatic basin following injection of blue dye in the site of the primary melanoma. Sentinel node biopsy may represent a feasible technique for early identification of occult disease. A therapeutic dissection is then performed only in patients with proven nodal disease, thus introducing the concept of selective dissection. Methods At the National Cancer Institute of Milan from February 1994 to October 1996, 74 patients with a melanoma of the trunk or limbs and without clinically detectable node metastases were submitted to sentinel node biopsy and eventual selective dissection. Results The sentinel node was identified in 67 patients (90%). Nodal metastases were detected in 11 patients (16%); 5 of these were identified by an intraoperative frozen section examination. In all but one case, only the sentinel node was affected at radical dissection. Incidence of positive sentinel nodes was correlated with depth of infiltration of the primary lesion. Mapped nodal basin failures were observed in 3 patients with negative sentinel node biopsy. All patients but one, presenting distant metastases, are alive at this writing and free of disease with a follow-up ranging from 2 to 34 months. Conclusions Our study adds to accumulating evidence supporting the efficacy of sentinel node biopsy in detecting occult localizations and the potential of the technique to better select the group of patients that may benefit from nodal dissection.

scholarly journals Added value of blue dye injection in sentinel node biopsy of breast cancer patients: Do all patients need blue dye?

2014 ◽  
Vol 12 (4) ◽  
pp. 325-328 ◽  
Author(s):  
Ramin Sadeghi ◽  
Ghazaleh Alesheikh ◽  
Seyed Rasoul Zakavi ◽  
Asiehsadat Fattahi ◽  
Abbas Abdollahi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sentinel Node ◽  
Cancer Patients ◽  
Sentinel Node Biopsy ◽  
Added Value ◽  
Blue Dye ◽  
Breast Cancer Patients ◽  
Node Biopsy

scholarly journals Risk Factors for a False-Negative Result of Sentinel Node Biopsy in Patients with Clinically Node-Negative Breast Cancer

2018 ◽  
Vol 50 (3) ◽  
pp. 625-633 ◽  
Author(s):  
Seung Ah Lee ◽  
Hak Min Lee ◽  
Hak Woo Lee ◽  
Ban Seok Yang ◽  
Jong Tae Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
False Negative ◽  
False Negative Result ◽  
Node Negative ◽  
Node Biopsy ◽  
Node Negative Breast Cancer

scholarly journals Thyroid Lymphosonography: A Novel Method for Evaluating Lymphatic Drainage

2009 ◽  
Vol 118 (9) ◽  
pp. 645-650 ◽  
Author(s):  
Joseph M. Curry ◽  
Waleed H. Ezzat ◽  
Daniel A. Merton ◽  
Barry B. Goldberg ◽  
David M. Cognetti ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Lymphatic Drainage ◽  
Blue Dye ◽  
Lymphatic Channel ◽  
Superior Mediastinum ◽  
Mediastinal Dissection ◽  
Node Biopsy ◽  
Contrast Enhanced

Objectives: We evaluated lymphosonography, or contrast-enhanced, ultrasonography (US)–guided sentinel lymph node (SLN) detection, as a technique for demonstrating the lymphatic drainage of the thyroid gland. Methods: In this prospective animal study, four 50-kg Yorkshire swine underwent transcutaneous injection of a US contrast agent and methylene blue dye into the thyroid gland. Contrast-enhanced US was used to identify draining lymphatic channels and SLNs. Sentinel node biopsy was conducted. Subsequently, bilateral neck and upper mediastinal dissection was carried out. Results: In 3 of 4 cases, a blue dye–positive and US contrast–positive SLN was identified. We identified SLNs in level IV in 2 cases. One case revealed 2 adjacent nodes in the superior mediastinum. In 1 case, a lymphatic channel was identified traveling into the mediastinum, but exposure of the SLN could not be obtained. No residual blue dye–positive or US contrast–positive nodes were identified on subsequent dissection. Conclusions: Lymphosonography of the thyroid gland in a porcine model correlates well with blue dye–guided sentinel node biopsy and is technically feasible, although in some cases access to the SLN may be difficult. This technique could potentially enable a detailed analysis of thyroidal lymphatic drainage if applied to humans.

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