Chemical Biology Wave Mechanics and Molecular Biology Louis de Broglie

BioScience ◽  
1968 ◽  
Vol 18 (1) ◽  
pp. 55-56
Author(s):  
David M. Gates
Keyword(s):  
Molecular Biology ◽  
Chemical Biology ◽  
Wave Mechanics

scholarly journals A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry-based Glycoproteomics

2020 ◽  
pp. mcp.R120.002277 ◽  
Author(s):  
Nicholas M Riley ◽  
Carolyn R Bertozzi ◽  
Sharon J Pitteri
Keyword(s):  
Mass Spectrometry ◽  
Molecular Biology ◽  
Chemical Biology ◽  
Hydrophilic Interaction Chromatography ◽  
Porous Graphitic Carbon ◽  
Graphitic Carbon ◽  
Hydrophilic Interaction ◽  
Chemical Coupling ◽  
Modern Mass ◽  
Enrichment Strategy

Glycosylation is a prevalent, yet heterogeneous modification with a broad range of implications in molecular biology. This heterogeneity precludes enrichment strategies that can be universally beneficial for all glycan classes. Thus, choice of enrichment strategy has profound implications on experimental outcomes. Here we review common enrichment strategies used in modern mass spectrometry (MS)-based glycoproteomic experiments, including lectins and other affinity chromatographies, hydrophilic interaction chromatography (HILIC) and its derivatives, porous graphitic carbon (PGC), reversible and irreversible chemical coupling strategies, and chemical biology tools that often leverage bioorthogonal handles. Interest in glycoproteomics continues to surge as MS instrumentation and software improve, so this review aims to help equip researchers with necessary information to choose appropriate enrichment strategies that best complement these efforts.

A List of Highly Influential Journals

2021 ◽  
Vol 11 ◽  
Author(s):  
Editorial Office ROS
Keyword(s):  
Internal Medicine ◽  
Heart Failure ◽  
Molecular Biology ◽  
Cell Biology ◽  
Chemical Biology ◽  
Cell Cancer ◽  
The United States ◽  
Experimental Medicine ◽  
Alphabetical Order ◽  
Cell Cell

This Education & Resources web page provides a list, in alphabetical order, of highly influential journals (typically with an impact factor of 10 or above) where high profile research articles on ROS may be found. This, however, is not intended to be a complete list. LIST IN ALPHABETICAL ORDER American Journal of Gastroenterology American Journal of Human Genetics American Journal of Respiratory and Critical Care Medicine Annals of Internal Medicine Annals of Neurology Autophagy Blood Brain British Medical Journal Cancer Research Cell (and Molecular Cell, Cancer Cell, Cell Metabolism, Cell Stem Cell, Developmental Cell, Cell Host Microbe) Cell Research Chest Circulation Circulation Research Current Biology EMBO J (and EMBO Molecular Medicine) European Heart Journal European Journal of Heart Failure European Respiratory Journal Gastroenterology Genes and Development Genome Biology Genome Research Gut Hepatology Immunity JAMA (and JAMA Internal Medicine, JAMA Cardiology) Journal of Allergy and Clinical Immunology Journal of the American College of Cardiology (and JACC Cardiovascular Imaging, JACC Cardiovascular Interventions, JACC Heart Failure)    Journal of Cell Biology Journal of Clinical Investigation Journal of Experimental Medicine Journal of the American Chemical Society Journal of the National Cancer Institute Lancet (and Lancet Oncology, Lancet Neurology, Lancet Diabetes & Endocrinology) Microbiome Molecular Biology and Evolution Molecular Cancer Molecular Plant Nature (and Nature Genetics, Nature Medicine, Nature Methods, Nature Biotechnology, Nature Materials, Nature Nanotechnology, Nature Communications, Nature Structural & Molecular Biology, Nature Neuroscience, Nature Immunology, Nature Cell Biology, Nature Chemical Biology, Nature Microbiology, Nature Plants, Nature Chemical Biology) Neuron New England Journal of Medicine Nucleic Acids Research Plant Cell PLOS Medicine Proceedings of the National Academy of Sciences of the United States of America Science (and Science Signaling, Science Translational Medicine, Science Immunology)

scholarly journals Accelerating the field of epigenetic histone modification through mass spectrometry-based approaches

2020 ◽  
pp. mcp.R120.002257
Author(s):  
Congcong Lu ◽  
Mariel Coradin ◽  
Elizabeth G Porter ◽  
Benjamin A Garcia
Keyword(s):  
Mass Spectrometry ◽  
Molecular Biology ◽  
Histone Modification ◽  
High Throughput ◽  
Epigenetic Regulation ◽  
Associated Factors ◽  
Chemical Biology ◽  
Post Translational Modifications ◽  
Histone Ptms ◽  
Chromatin Biology

Histone post-translational modifications (PTMs) are one of the main mechanisms of epigenetic regulation. Dysregulation of histone PTMs leads to many human diseases, such as cancer. Due to its high-throughput, accuracy, and flexibility, mass spectrometry (MS) has emerged as a powerful tool in the epigenetic histone modification field, allowing the comprehensive and unbiased analysis of histone PTMs and chromatin-associated factors. Coupled with various techniques from molecular biology, biochemistry, chemical biology and biophysics, MS has been employed to characterize distinct aspects of histone PTMs in the epigenetic regulation of chromatin functions. In this review we will describe advancements in the field of MS that have facilitated the analysis of histone PTMs and chromatin biology.  

Wave Mechanics and Molecular Biology. Louis de Broglie

1967 ◽  
Vol 42 (4) ◽  
pp. 566-567
Author(s):  
David B. Millar
Keyword(s):  
Molecular Biology ◽  
Wave Mechanics

Wave Mechanics and Molecular Biology

Physics Today ◽  
1967 ◽  
Vol 20 (6) ◽  
pp. 77-79
Author(s):  
Louis de Broglie ◽  
R. Bruce Lindsay
Keyword(s):  
Molecular Biology ◽  
Wave Mechanics

Electron Microscopy in Molecular Biology

1967 ◽  
Vol 25 ◽  
pp. 2-3
Author(s):  
Cecil E. Hall
Keyword(s):  
Electron Microscopy ◽  
Molecular Biology ◽  
Noise Level ◽  
Molecular Structures ◽  
Material Structure ◽  
The Arts ◽  
Shadow Casting ◽  
Electron Image ◽  
High Degree ◽  
Very High

The visualization of organic macromolecules such as proteins, nucleic acids, viruses and virus components has reached its high degree of effectiveness owing to refinements and reliability of instruments and to the invention of methods for enhancing the structure of these materials within the electron image. The latter techniques have been most important because what can be seen depends upon the molecular and atomic character of the object as modified which is rarely evident in the pristine material. Structure may thus be displayed by the arts of positive and negative staining, shadow casting, replication and other techniques. Enhancement of contrast, which delineates bounds of isolated macromolecules has been effected progressively over the years as illustrated in Figs. 1, 2, 3 and 4 by these methods. We now look to the future wondering what other visions are waiting to be seen. The instrument designers will need to exact from the arts of fabrication the performance that theory has prescribed as well as methods for phase and interference contrast with explorations of the potentialities of very high and very low voltages. Chemistry must play an increasingly important part in future progress by providing specific stain molecules of high visibility, substrates of vanishing “noise” level and means for preservation of molecular structures that usually exist in a solvated condition.

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