Cercarial Slide Flocculation and Circumoval Precipitin Tests on Cebus Monkeys Experimentally Infected with Schistosoma mansoni

Derivatives of acridine (9-Acridanone-hydrazones) were tested in Cebus monkeys experimentally infected with Schistosoma mansoni, at the dosages of 50, 25, and 12.5 mg/kg (p.o., single dose). At least, four compounds seemed to be very promising, promoting alterations in the oogram and reducing the worm burden drastically, even at the lowest dose (12.5 mg/kg). No side effects could be detected after drug administration.

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Rectal Biopsy and Mucosal Curettage in Cebus Monkeys Experimentally Infected with Schistosoma mansoni and Schistosoma japonicum

Journal of Parasitology ◽

10.2307/3276244 ◽

1965 ◽

Vol 51 (4) ◽

pp. 617 ◽

Cited By ~ 14

Author(s):

J. Pellegrino ◽

Naftale Katz ◽

Celso A. Oliveira ◽

K. Okabe

Keyword(s):

Schistosoma Mansoni ◽

Schistosoma Japonicum ◽

Rectal Biopsy ◽

Cebus Monkeys

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Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86821995000300003 ◽

1995 ◽

Vol 28 (3) ◽

pp. 179-183 ◽

Cited By ~ 7

Author(s):

Paulo Marcos Zech Coelho ◽

Leógenes Horácio Pereira ◽

Rômulo Teixeira de Mello

Keyword(s):

Body Weight ◽

Schistosoma Mansoni ◽

Apparent Absence ◽

Antischistosomal Activity ◽

Cebus Monkeys

In this study, four compounds were utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried out periodically, showed no viable eggs of the parasite, from day 29 to 226post-treatment. The perfusion undertaken after killing the animals showed absence of worms in the treated monkeys, whereas 83 worms were recovered from the control, thus corroborating the results obtained by means of oograms and coproscopy. These results confirm the efficacy of 9-acridanone- hydrazones previously tested against the LE strain of S. mansoni. The low curative dose and apparent absence of toxicity render these dmgs an important therapeutic reserve, taking into consideration the reports on the resistance of S. mansoni to the modern drugs oxamniquine and praziquantel.

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Transplantation of adult Schistosoma mansoni from mice to the portal system of Cebus monkeys immunized against the donor host

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1016/0035-9203(79)90143-3 ◽

1979 ◽

Vol 73 (1) ◽

pp. 113-114 ◽

Cited By ~ 1

Author(s):

P.M.Z. Coelho ◽

J.R.C. Melo ◽

L.H. Pereira ◽

E. Nascimento

Keyword(s):

Schistosoma Mansoni ◽

Portal System ◽

Cebus Monkeys

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Ultrastructural analysis of “Sensory” surface nerve endings and “putative” neurotransmitter sites in Schistosoma mansoni Miracidia

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100156791 ◽

1989 ◽

Vol 47 ◽

pp. 962-963

Author(s):

Betty Ruth Jones ◽

Steve Chi-Tang Pan

Keyword(s):

Nervous System ◽

Life Cycle ◽

Schistosoma Mansoni ◽

Snail Host ◽

Complex Life Cycle ◽

Rational Approach ◽

Effective Control ◽

The Social ◽

Social And Economic Development ◽

Basic Biology

INTRODUCTION: Schistosomiasis has been described as “one of the most devastating diseases of mankind, second only to malaria in its deleterious effects on the social and economic development of populations in many warm areas of the world.” The disease is worldwide and is probably spreading faster and becoming more intense than the overall research efforts designed to provide the basis for countering it. Moreover, there are indications that the development of water resources and the demands for increasing cultivation and food in developing countries may prevent adequate control of the disease and thus the number of infections are increasing.Our knowledge of the basic biology of the parasites causing the disease is far from adequate. Such knowledge is essential if we are to develop a rational approach to the effective control of human schistosomiasis. The miracidium is the first infective stage in the complex life cycle of schistosomes. The future of the entire life cycle depends on the capacity and ability of this organism to locate and enter a suitable snail host for further development, Little is known about the nervous system of the miracidium of Schistosoma mansoni and of other trematodes. Studies indicate that miracidia contain a well developed and complex nervous system that may aid the larvae in locating and entering a susceptible snail host (Wilson, 1970; Brooker, 1972; Chernin, 1974; Pan, 1980; Mehlhorn, 1988; and Jones, 1987-1988).

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